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Article: Derivative (1;18)(q10;q10)a recurrent and novel unbalanced translocation involving 1q in myeloid disorders

TitleDerivative (1;18)(q10;q10)a recurrent and novel unbalanced translocation involving 1q in myeloid disorders
Authors
Issue Date2001
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergene
Citation
Cancer Genetics And Cytogenetics, 2001, v. 128 n. 1, p. 35-38 How to Cite?
AbstractWe report two cases of hematological malignancies, comprising a case of myelodysplastic syndrome (MDS) that rapidly evolved into acute myeloid leukemia, and a case of myeloproliferative disorder (MPD), in which der(1;18)(q10;q10) was found as the sole acquired karyotypic abnormality. This observation indicates that the unbalanced translocation is a recurrent aberration in myeloid disorders. To the best of our knowledge, centromeric fusion between long arms of chromosomes 1 and 18, leading to a normal chromosome 18 substituted with a der(1;18) chromosome, is novel and has not been described in cancer. Mechanistically, either trisomy 1q or monosomy 18p that results from the translocation may potentially contribute to leukemogenesis. Finally, chromosomes with large constitutive heterochromatin bands such as chromosome 1 may be at risk of centromeric instability and be predisposed to centromeric fusion with other chromosomes. Copyright © 2001 Elsevier Science Inc.
Persistent Identifierhttp://hdl.handle.net/10722/148253
ISSN
2012 Impact Factor: 1.929
2013 SCImago Journal Rankings: 0.872
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWan, TSKen_US
dc.contributor.authorMa, SKen_US
dc.contributor.authorAu, WYen_US
dc.contributor.authorChan, LCen_US
dc.date.accessioned2012-05-29T06:11:48Z-
dc.date.available2012-05-29T06:11:48Z-
dc.date.issued2001en_US
dc.identifier.citationCancer Genetics And Cytogenetics, 2001, v. 128 n. 1, p. 35-38en_US
dc.identifier.issn0165-4608en_US
dc.identifier.urihttp://hdl.handle.net/10722/148253-
dc.description.abstractWe report two cases of hematological malignancies, comprising a case of myelodysplastic syndrome (MDS) that rapidly evolved into acute myeloid leukemia, and a case of myeloproliferative disorder (MPD), in which der(1;18)(q10;q10) was found as the sole acquired karyotypic abnormality. This observation indicates that the unbalanced translocation is a recurrent aberration in myeloid disorders. To the best of our knowledge, centromeric fusion between long arms of chromosomes 1 and 18, leading to a normal chromosome 18 substituted with a der(1;18) chromosome, is novel and has not been described in cancer. Mechanistically, either trisomy 1q or monosomy 18p that results from the translocation may potentially contribute to leukemogenesis. Finally, chromosomes with large constitutive heterochromatin bands such as chromosome 1 may be at risk of centromeric instability and be predisposed to centromeric fusion with other chromosomes. Copyright © 2001 Elsevier Science Inc.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergeneen_US
dc.relation.ispartofCancer Genetics and Cytogeneticsen_US
dc.subject.meshAcute Diseaseen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshChromosome Aberrations - Geneticsen_US
dc.subject.meshChromosome Disordersen_US
dc.subject.meshChromosomes, Human, Pair 1 - Geneticsen_US
dc.subject.meshChromosomes, Human, Pair 18 - Geneticsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHematologic Diseases - Geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshIn Situ Hybridization, Fluorescenceen_US
dc.subject.meshKaryotypingen_US
dc.subject.meshMaleen_US
dc.subject.meshMyelodysplastic Syndromes - Geneticsen_US
dc.subject.meshMyeloproliferative Disorders - Geneticsen_US
dc.subject.meshTranslocation, Geneticen_US
dc.titleDerivative (1;18)(q10;q10)a recurrent and novel unbalanced translocation involving 1q in myeloid disordersen_US
dc.typeArticleen_US
dc.identifier.emailChan, LC:chanlc@hkucc.hku.hken_US
dc.identifier.authorityChan, LC=rp00373en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0165-4608(01)00391-0en_US
dc.identifier.pmid11454427-
dc.identifier.scopuseid_2-s2.0-0035395724en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035395724&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume128en_US
dc.identifier.issue1en_US
dc.identifier.spage35en_US
dc.identifier.epage38en_US
dc.identifier.isiWOS:000169770900007-
dc.publisher.placeUnited Statesen_US

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