File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1002/1097-0215(20010601)92:5<692::AID-IJC1237>3.0.CO;2-Z
- Scopus: eid_2-s2.0-0035371668
- PMID: 11340574
- WOS: WOS:000168420400013
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Expression of HLA class I, β2-microglobulin, TAP1 and IL-10 in epstein-barr virus-associated nasal NK/T-cell lymphoma: Implications for tumor immune escape mechanism
Title | Expression of HLA class I, β2-microglobulin, TAP1 and IL-10 in epstein-barr virus-associated nasal NK/T-cell lymphoma: Implications for tumor immune escape mechanism |
---|---|
Authors | |
Keywords | β2-microglobulin Epstein-Barr virus HLA class 1,immune escape Interleukin-10 Nasal NK/T-cell lymphoma TAP 1 |
Issue Date | 2001 |
Publisher | John Wiley & Sons, Inc.. The Journal's web site is located at http://www3.interscience.wiley.com/journal/29331/home |
Citation | International Journal Of Cancer, 2001, v. 92 n. 5, p. 692-696 How to Cite? |
Abstract | Several mechanisms of immune escape might be in operation in Epstein-Barr virus (EBV)-associated nasal NK/T-cell lymphoma. We have previously shown the downregulation of the immunogenic EBV nuclear antigens by alternative promoter usage and the preferential selection of the deletion genotype of latent membrane protein I in nasal lymphoma. To understand further the strategies used for immune escape by this tumor, we examined by immunohistochemistry HLA class I expression in 15 cases using frozen sections, along with β2-microglobulin and transporter associated with antigen processing I (TAPI) expression in 39 cases using paraffin sections. All nasal NK/T-cell lymphomas showed positive staining for HLA class I, β2-microglobulin and TAP I on most tumor cells, except for two cases (5%) in which most of the tumor cells lacked β2-microglobulin staining. We next immunostained for interleukin-10 on frozen sections in 13 cases, all of which showed strong expression by most tumor cells. Transcription of human interleukin-10 but not EBV BCRF I (viral interleukin-10) was identified by reverse transcriptase-polymerase chain reaction in these nasal NK/T-cell lymphomas. Overall, our data suggest that global downregulation of HLA class I or TAP I rarely accounts for the ability of nasal NK/T-cell lymphoma to evade immunosurveillance and that other immune escape mechanisms may be operating in nasal NK/T-cell lymphoma, such as production of interleukin-10 to suppress the local immune response. © 2001 Wiley-Liss, Inc. |
Persistent Identifier | http://hdl.handle.net/10722/148251 |
ISSN | 2023 Impact Factor: 5.7 2023 SCImago Journal Rankings: 2.131 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Shen, L | en_HK |
dc.contributor.author | Chiang, AKS | en_HK |
dc.contributor.author | Liu, WP | en_HK |
dc.contributor.author | Li, GD | en_HK |
dc.contributor.author | Liang, RHS | en_HK |
dc.contributor.author | Srivastava, G | en_HK |
dc.date.accessioned | 2012-05-29T06:11:48Z | - |
dc.date.available | 2012-05-29T06:11:48Z | - |
dc.date.issued | 2001 | en_HK |
dc.identifier.citation | International Journal Of Cancer, 2001, v. 92 n. 5, p. 692-696 | en_HK |
dc.identifier.issn | 0020-7136 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/148251 | - |
dc.description.abstract | Several mechanisms of immune escape might be in operation in Epstein-Barr virus (EBV)-associated nasal NK/T-cell lymphoma. We have previously shown the downregulation of the immunogenic EBV nuclear antigens by alternative promoter usage and the preferential selection of the deletion genotype of latent membrane protein I in nasal lymphoma. To understand further the strategies used for immune escape by this tumor, we examined by immunohistochemistry HLA class I expression in 15 cases using frozen sections, along with β2-microglobulin and transporter associated with antigen processing I (TAPI) expression in 39 cases using paraffin sections. All nasal NK/T-cell lymphomas showed positive staining for HLA class I, β2-microglobulin and TAP I on most tumor cells, except for two cases (5%) in which most of the tumor cells lacked β2-microglobulin staining. We next immunostained for interleukin-10 on frozen sections in 13 cases, all of which showed strong expression by most tumor cells. Transcription of human interleukin-10 but not EBV BCRF I (viral interleukin-10) was identified by reverse transcriptase-polymerase chain reaction in these nasal NK/T-cell lymphomas. Overall, our data suggest that global downregulation of HLA class I or TAP I rarely accounts for the ability of nasal NK/T-cell lymphoma to evade immunosurveillance and that other immune escape mechanisms may be operating in nasal NK/T-cell lymphoma, such as production of interleukin-10 to suppress the local immune response. © 2001 Wiley-Liss, Inc. | en_HK |
dc.language | eng | en_US |
dc.publisher | John Wiley & Sons, Inc.. The Journal's web site is located at http://www3.interscience.wiley.com/journal/29331/home | en_HK |
dc.relation.ispartof | International Journal of Cancer | en_HK |
dc.rights | International Journal of Cancer. Copyright © John Wiley & Sons, Inc. | - |
dc.subject | β2-microglobulin | en_HK |
dc.subject | Epstein-Barr virus | en_HK |
dc.subject | HLA class 1,immune escape | en_HK |
dc.subject | Interleukin-10 | en_HK |
dc.subject | Nasal NK/T-cell lymphoma | en_HK |
dc.subject | TAP 1 | en_HK |
dc.subject.mesh | Atp-Binding Cassette Transporters - Analysis | en_US |
dc.subject.mesh | Epstein-Barr Virus Infections - Immunology | en_US |
dc.subject.mesh | Histocompatibility Antigens Class I - Analysis | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Immunohistochemistry | en_US |
dc.subject.mesh | Interleukin-10 - Analysis | en_US |
dc.subject.mesh | Lymphoma, T-Cell - Immunology | en_US |
dc.subject.mesh | Nose Neoplasms - Immunology | en_US |
dc.subject.mesh | Beta 2-Microglobulin - Analysis | en_US |
dc.title | Expression of HLA class I, β2-microglobulin, TAP1 and IL-10 in epstein-barr virus-associated nasal NK/T-cell lymphoma: Implications for tumor immune escape mechanism | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Chiang, AKS:chiangak@hkucc.hku.hk | en_HK |
dc.identifier.email | Liang, RHS:rliang@hku.hk | en_HK |
dc.identifier.email | Srivastava, G:gopesh@pathology.hku.hk | en_HK |
dc.identifier.authority | Chiang, AKS=rp00403 | en_HK |
dc.identifier.authority | Liang, RHS=rp00345 | en_HK |
dc.identifier.authority | Srivastava, G=rp00365 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1002/1097-0215(20010601)92:5<692::AID-IJC1237>3.0.CO;2-Z | en_HK |
dc.identifier.pmid | 11340574 | - |
dc.identifier.scopus | eid_2-s2.0-0035371668 | en_HK |
dc.identifier.hkuros | 56983 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0035371668&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 92 | en_HK |
dc.identifier.issue | 5 | en_HK |
dc.identifier.spage | 692 | en_HK |
dc.identifier.epage | 696 | en_HK |
dc.identifier.isi | WOS:000168420400013 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.scopusauthorid | Shen, L=7401704659 | en_HK |
dc.identifier.scopusauthorid | Chiang, AKS=7101623534 | en_HK |
dc.identifier.scopusauthorid | Liu, WP=24312055100 | en_HK |
dc.identifier.scopusauthorid | Li, GD=8379895000 | en_HK |
dc.identifier.scopusauthorid | Liang, RHS=26643224900 | en_HK |
dc.identifier.scopusauthorid | Srivastava, G=7202242238 | en_HK |
dc.identifier.issnl | 0020-7136 | - |