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Article: Anti-tumor effects of human peripheral γδ T cells in a mouse tumor model

TitleAnti-tumor effects of human peripheral γδ T cells in a mouse tumor model
Authors
Keywordsγδ T cells
Anti-tumor effect
Mouse tumor model
NPC
Tumor-infiltrating lymphocytes
Issue Date2001
PublisherJohn Wiley & Sons, Inc.. The Journal's web site is located at http://www3.interscience.wiley.com/journal/29331/home
Citation
International Journal Of Cancer, 2001, v. 92 n. 3, p. 421-425 How to Cite?
AbstractPeripheral γδ T cells derived from healthy donors were found to exhibit cytotoxicity against a variety of tumor cell lines in vitro, including CNE2, which was established from nasopharyngeal carcinoma (NPC). The anti-tumor effects were further studied in a mouse model. Control nude mice inoculated s.c. with 5 × 10 6 CNE2 cells regularly developed hypodermal tumors, which progressively increased in size, and animals had a mean survival of 35 ± 3.4 days. Tumor growth was arrested and tumor size was reduced after animals were infused with 5 × 10 7 γδ T cells derived from a healthy donor. The anti-tumor effects were temporary, however, and tumor growth was resumed after about 1 week in a group of the animals that had been given a single dose of γδ T cells. In another group of animals given 2 doses of γδ cells 1 week apart, resumption of tumor growth was delayed for a further week. Mean survival of the 2 groups was increased to 61 ± 15.7 and 74 ± 12.9 days, respectively. Immunohistology revealed an accumulation of infused cells in tumors attended by focal tumor necrosis in specimens taken 2 days after infusion. Infiltrative cells virtually disappeared from tumor tissues 6 days after infusion, accompanied by increased mitotic indices of tumor cells. These temporal relationships suggested that the accumulation of infused γδ T cells in hypodermal tumors was responsible for the observed anti-tumor effects. © 2001 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/148249
ISSN
2015 Impact Factor: 5.531
2015 SCImago Journal Rankings: 2.657
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZheng, BJen_HK
dc.contributor.authorChan, KWen_HK
dc.contributor.authorIm, Sen_HK
dc.contributor.authorChua, Den_HK
dc.contributor.authorSham, JSTen_HK
dc.contributor.authorTin, PCen_HK
dc.contributor.authorHe, ZMen_HK
dc.contributor.authorNg, MHen_HK
dc.date.accessioned2012-05-29T06:11:47Z-
dc.date.available2012-05-29T06:11:47Z-
dc.date.issued2001en_HK
dc.identifier.citationInternational Journal Of Cancer, 2001, v. 92 n. 3, p. 421-425en_HK
dc.identifier.issn0020-7136en_HK
dc.identifier.urihttp://hdl.handle.net/10722/148249-
dc.description.abstractPeripheral γδ T cells derived from healthy donors were found to exhibit cytotoxicity against a variety of tumor cell lines in vitro, including CNE2, which was established from nasopharyngeal carcinoma (NPC). The anti-tumor effects were further studied in a mouse model. Control nude mice inoculated s.c. with 5 × 10 6 CNE2 cells regularly developed hypodermal tumors, which progressively increased in size, and animals had a mean survival of 35 ± 3.4 days. Tumor growth was arrested and tumor size was reduced after animals were infused with 5 × 10 7 γδ T cells derived from a healthy donor. The anti-tumor effects were temporary, however, and tumor growth was resumed after about 1 week in a group of the animals that had been given a single dose of γδ T cells. In another group of animals given 2 doses of γδ cells 1 week apart, resumption of tumor growth was delayed for a further week. Mean survival of the 2 groups was increased to 61 ± 15.7 and 74 ± 12.9 days, respectively. Immunohistology revealed an accumulation of infused cells in tumors attended by focal tumor necrosis in specimens taken 2 days after infusion. Infiltrative cells virtually disappeared from tumor tissues 6 days after infusion, accompanied by increased mitotic indices of tumor cells. These temporal relationships suggested that the accumulation of infused γδ T cells in hypodermal tumors was responsible for the observed anti-tumor effects. © 2001 Wiley-Liss, Inc.en_HK
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc.. The Journal's web site is located at http://www3.interscience.wiley.com/journal/29331/homeen_HK
dc.relation.ispartofInternational Journal of Canceren_HK
dc.subjectγδ T cellsen_HK
dc.subjectAnti-tumor effecten_HK
dc.subjectMouse tumor modelen_HK
dc.subjectNPCen_HK
dc.subjectTumor-infiltrating lymphocytesen_HK
dc.subject.meshAnimalsen_US
dc.subject.meshDisease Models, Animalen_US
dc.subject.meshImmunotherapyen_US
dc.subject.meshLymphocytes, Tumor-Infiltrating - Immunologyen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Inbred Balb Cen_US
dc.subject.meshMice, Nudeen_US
dc.subject.meshNeoplasm Transplantationen_US
dc.subject.meshNeoplasms, Experimental - Immunology - Pathology - Therapyen_US
dc.subject.meshReceptors, Antigen, T-Cell, Gamma-Delta - Analysisen_US
dc.subject.meshT-Lymphocytes - Immunology - Physiologyen_US
dc.subject.meshTumor Cells, Cultureden_US
dc.titleAnti-tumor effects of human peripheral γδ T cells in a mouse tumor modelen_HK
dc.typeArticleen_HK
dc.identifier.emailZheng, BJ: bzheng@hkucc.hku.hken_HK
dc.identifier.emailChan, KW: hrmtckw@hku.hken_HK
dc.identifier.emailChua, D: dttchua@hkucc.hku.hken_HK
dc.identifier.authorityZheng, BJ=rp00353en_HK
dc.identifier.authorityChan, KW=rp00330en_HK
dc.identifier.authorityChua, D=rp00415en_HK
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1002/ijc.1198en_HK
dc.identifier.pmid11291081-
dc.identifier.scopuseid_2-s2.0-0035342534en_HK
dc.identifier.hkuros61882en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035342534&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume92en_HK
dc.identifier.issue3en_HK
dc.identifier.spage421en_HK
dc.identifier.epage425en_HK
dc.identifier.isiWOS:000167851400019-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridZheng, BJ=7201780588en_HK
dc.identifier.scopusauthoridChan, KW=16444133100en_HK
dc.identifier.scopusauthoridIm, S=22943859000en_HK
dc.identifier.scopusauthoridChua, D=7006773480en_HK
dc.identifier.scopusauthoridSham, JST=24472255400en_HK
dc.identifier.scopusauthoridTin, PC=6603931714en_HK
dc.identifier.scopusauthoridHe, ZM=35603357900en_HK
dc.identifier.scopusauthoridNg, MH=7202076421en_HK

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