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Article: Serological and molecular screening for viruses in blood donors from Ntcheu, Malawi: High prevalence of HIV-1 subtype C and of markers of hepatitis B and C viruses

TitleSerological and molecular screening for viruses in blood donors from Ntcheu, Malawi: High prevalence of HIV-1 subtype C and of markers of hepatitis B and C viruses
Authors
Issue Date2001
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/32763
Citation
Journal Of Medical Virology, 2001, v. 65 n. 1, p. 1-5 How to Cite?
AbstractThe prevalence of antibodies to human immunodeficiency virus type 1 (HIV-1), hepatitis C virus (HCV), human T lymphotropic virus I (HTLV-1), and hepatitis B (HBV) surface antigen (HBsAg) was determined in blood donors from Ntcheu, Malawi. Each donation was also screened for HIV-1 RNA and HCV RNA. Among 159 blood donations, the prevalence of HIV-1 infection was 10.7%, 8.1% for HBV carriage, 6.8% for anti-HCV, and 2.5% for anti-HTLV-1. HIV-1/HTLV-1 and HIV-1/ HCV dual infections were observed in 1.2% of the donations. Consequently, 13% of blood donors from Ntcheu should be deferred for retroviral infections and 15% for hepatitis viral infections. Sequence analyses of the HIV-1 strains revealed a relatively homogeneous circulation of subtype C viruses in Malawi. These findings confirm the high endemicity of blood-borne viruses in Malawi and the need for a sensitive viral screening of blood donations to improve blood safety. © 2001 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/148224
ISSN
2015 Impact Factor: 1.998
2015 SCImago Journal Rankings: 1.015
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorNicholls, Jen_US
dc.contributor.authorKremmer, Een_US
dc.contributor.authorMeseda, CAen_US
dc.contributor.authorMackett, Men_US
dc.contributor.authorHahn, Pen_US
dc.contributor.authorGulley, MLen_US
dc.contributor.authorBrink, Aen_US
dc.contributor.authorSwinnen, LJen_US
dc.contributor.authorGreenspan, Jen_US
dc.contributor.authorDe Souza, Yen_US
dc.contributor.authorSham, FGJen_US
dc.contributor.authorNg, MHen_US
dc.contributor.authorArrand, JRen_US
dc.date.accessioned2012-05-29T06:11:37Z-
dc.date.available2012-05-29T06:11:37Z-
dc.date.issued2001en_US
dc.identifier.citationJournal Of Medical Virology, 2001, v. 65 n. 1, p. 1-5en_US
dc.identifier.issn0146-6615en_US
dc.identifier.urihttp://hdl.handle.net/10722/148224-
dc.description.abstractThe prevalence of antibodies to human immunodeficiency virus type 1 (HIV-1), hepatitis C virus (HCV), human T lymphotropic virus I (HTLV-1), and hepatitis B (HBV) surface antigen (HBsAg) was determined in blood donors from Ntcheu, Malawi. Each donation was also screened for HIV-1 RNA and HCV RNA. Among 159 blood donations, the prevalence of HIV-1 infection was 10.7%, 8.1% for HBV carriage, 6.8% for anti-HCV, and 2.5% for anti-HTLV-1. HIV-1/HTLV-1 and HIV-1/ HCV dual infections were observed in 1.2% of the donations. Consequently, 13% of blood donors from Ntcheu should be deferred for retroviral infections and 15% for hepatitis viral infections. Sequence analyses of the HIV-1 strains revealed a relatively homogeneous circulation of subtype C viruses in Malawi. These findings confirm the high endemicity of blood-borne viruses in Malawi and the need for a sensitive viral screening of blood donations to improve blood safety. © 2001 Wiley-Liss, Inc.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/32763en_US
dc.relation.ispartofJournal of Medical Virologyen_US
dc.subject.meshAmino Acid Sequenceen_US
dc.subject.meshAntibodies, Viral - Blooden_US
dc.subject.meshBlood Donorsen_US
dc.subject.meshHiv Antibodies - Blooden_US
dc.subject.meshHiv Infections - Epidemiologyen_US
dc.subject.meshHiv Seroprevalenceen_US
dc.subject.meshHiv-1 - Classification - Genetics - Immunology - Isolation & Purificationen_US
dc.subject.meshHtlv-I Antibodies - Blooden_US
dc.subject.meshHtlv-I Infections - Epidemiologyen_US
dc.subject.meshHepacivirus - Isolation & Purificationen_US
dc.subject.meshHepatitis B - Epidemiologyen_US
dc.subject.meshHepatitis B Surface Antigens - Analysisen_US
dc.subject.meshHepatitis C - Epidemiologyen_US
dc.subject.meshHepatitis C Antibodies - Blooden_US
dc.subject.meshHumansen_US
dc.subject.meshMalawi - Epidemiologyen_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshPhylogenyen_US
dc.subject.meshPrevalenceen_US
dc.subject.meshRna, Viral - Blooden_US
dc.titleSerological and molecular screening for viruses in blood donors from Ntcheu, Malawi: High prevalence of HIV-1 subtype C and of markers of hepatitis B and C virusesen_US
dc.typeArticleen_US
dc.identifier.emailNicholls, J:nicholls@pathology.hku.hken_US
dc.identifier.authorityNicholls, J=rp00364en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/jmv.1093en_US
dc.identifier.pmid11505436-
dc.identifier.scopuseid_2-s2.0-0034907065en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034907065&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume65en_US
dc.identifier.issue1en_US
dc.identifier.spage1en_US
dc.identifier.epage5en_US
dc.identifier.isiWOS:000170257200001-
dc.publisher.placeUnited Statesen_US

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