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Article: Sinonasal angiosarcoma with marrow involvement at presentation mimicking malignant lymphoma: cytogenetic analysis using multiple techniques

TitleSinonasal angiosarcoma with marrow involvement at presentation mimicking malignant lymphoma: cytogenetic analysis using multiple techniques
Authors
Issue Date2001
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergene
Citation
Cancer Genetics and Cytogenetics, 2001, v. 129 n. 1, p. 64-68 How to Cite?
AbstractAngiosarcoma of the head and neck most commonly involves the skin of the scalp or face; primary involvement of the sinonasal region is exceedingly rate. We report a patient with sinonasal angiosarcoma who showed marrow involvement at presentation. Marrow aspiration smears showed many large, often segregated blast-like cells, mimicking malignant lymphoma. However, trephine biopsy revealed formation of anastomosing vascular spaces by the tumor cells and immunoreactivity for CD31, supporting a diagnosis of angiosarcoma. DNA ploidy analysis showed an apparent diploidy. Nevertheless, conventional cytogenetics demonstrated very complex chromosomal abnormalities with the presence of multiple hypodiploid clones, together with several near-triploid to near-tetraploid clones showing structural abnormalities involving chromosomes 1, 3, 4, 9, 14, 16, 17, 18, and 22. The identification of these karyotypic changes has been facilitated by the application of comparative genomic hybridization and spectral karyotyping. Copyright © 2001 Elsevier Science Inc.
Persistent Identifierhttp://hdl.handle.net/10722/148223
ISSN
2012 Impact Factor: 1.929
2013 SCImago Journal Rankings: 0.872
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWong, KFen_HK
dc.contributor.authorSo, CCen_HK
dc.contributor.authorWong, Nen_HK
dc.contributor.authorSiu, LLPen_HK
dc.contributor.authorKwong, YLen_HK
dc.contributor.authorChan, JKCen_HK
dc.date.accessioned2012-05-29T06:11:36Z-
dc.date.available2012-05-29T06:11:36Z-
dc.date.issued2001en_HK
dc.identifier.citationCancer Genetics and Cytogenetics, 2001, v. 129 n. 1, p. 64-68en_HK
dc.identifier.issn0165-4608en_HK
dc.identifier.urihttp://hdl.handle.net/10722/148223-
dc.description.abstractAngiosarcoma of the head and neck most commonly involves the skin of the scalp or face; primary involvement of the sinonasal region is exceedingly rate. We report a patient with sinonasal angiosarcoma who showed marrow involvement at presentation. Marrow aspiration smears showed many large, often segregated blast-like cells, mimicking malignant lymphoma. However, trephine biopsy revealed formation of anastomosing vascular spaces by the tumor cells and immunoreactivity for CD31, supporting a diagnosis of angiosarcoma. DNA ploidy analysis showed an apparent diploidy. Nevertheless, conventional cytogenetics demonstrated very complex chromosomal abnormalities with the presence of multiple hypodiploid clones, together with several near-triploid to near-tetraploid clones showing structural abnormalities involving chromosomes 1, 3, 4, 9, 14, 16, 17, 18, and 22. The identification of these karyotypic changes has been facilitated by the application of comparative genomic hybridization and spectral karyotyping. Copyright © 2001 Elsevier Science Inc.en_HK
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergeneen_HK
dc.relation.ispartofCancer Genetics and Cytogeneticsen_HK
dc.rightsCancer Genetics and Cytogenetics. Copyright © Elsevier Inc.-
dc.subject.meshAdulten_US
dc.subject.meshBone Marrow Neoplasms - Geneticsen_US
dc.subject.meshChromosome Aberrationsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenes, P53en_US
dc.subject.meshHemangiosarcoma - Geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshKaryotypingen_US
dc.subject.meshLymphoma - Geneticsen_US
dc.subject.meshParanasal Sinus Neoplasms - Geneticsen_US
dc.subject.meshSphenoid Sinusen_US
dc.titleSinonasal angiosarcoma with marrow involvement at presentation mimicking malignant lymphoma: cytogenetic analysis using multiple techniquesen_HK
dc.typeArticleen_HK
dc.identifier.emailSo, CC: scc@pathology.hku.hken_HK
dc.identifier.emailKwong, YL: ylkwong@hku.hken_HK
dc.identifier.authoritySo, CC=rp00391en_HK
dc.identifier.authorityKwong, YL=rp00358en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0165-4608(01)00431-9en_HK
dc.identifier.pmid11520569-
dc.identifier.scopuseid_2-s2.0-0034904062en_HK
dc.identifier.hkuros108098-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034904062&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume129en_HK
dc.identifier.issue1en_HK
dc.identifier.spage64en_HK
dc.identifier.epage68en_HK
dc.identifier.isiWOS:000170586400012-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridWong, KF=37096553800en_HK
dc.identifier.scopusauthoridSo, CC=7102919978en_HK
dc.identifier.scopusauthoridWong, N=7202834860en_HK
dc.identifier.scopusauthoridSiu, LLP=35574705900en_HK
dc.identifier.scopusauthoridKwong, YL=7102818954en_HK
dc.identifier.scopusauthoridChan, JKC=7403287069en_HK
dc.customcontrol.immutablesml 130621-

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