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Article: Molecular prognostication of nasopharyngeal carcinoma by quantitative analysis of circulating epstein-barr virus DNA

TitleMolecular prognostication of nasopharyngeal carcinoma by quantitative analysis of circulating epstein-barr virus DNA
Authors
Issue Date2000
PublisherAmerican Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/
Citation
Cancer Research, 2000, v. 60 n. 24, p. 6878-6881 How to Cite?
AbstractWe investigated the prognostic implication of pretreatment plasma/ serum EBV DNA concentration, as measured by real-time quantitative PCR, in nasopharyngeal carcinoma (NPC). In 91 prospectively recruited NPC patients, those with recurrence or metastasis within the first year after treatment had a higher median plasma EBV DNA concentration than those without events (41,756 copies/ml versus 5,807 copies/ml; P < 0.001, Mann-Whitney rank-sum test). In multivariate logistic regression analysis, plasma EBV DNA was an independent prognostic indicator for early clinical events [relative risk = 3.8 (95% confidence interval, 1.6-9.2 for each 10-fold increase in plasma EBV DNA concentration; P = 0.003)]. In a second cohort of 139 NPC patients followed-up for a median period of 2,027 days (interquartile range, 597-2,335 days), serum EBV DNA was found to be a significant variable associated with NPC-related death in multivariate Cox's regression analysis [relative risk = 1.6 (95% confidence interval, 1.1-2.1 for each 10-fold increase in serum EBV DNA concentration; P = 0.007)]. The quantitation of circulating EBV DNA may thus allow improved prognostication of NPC.
Persistent Identifierhttp://hdl.handle.net/10722/148216
ISSN
2015 Impact Factor: 8.556
2015 SCImago Journal Rankings: 5.372
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLo, YMDen_US
dc.contributor.authorChan, ATCen_US
dc.contributor.authorChan, LYSen_US
dc.contributor.authorLeung, SFen_US
dc.contributor.authorLam, CWen_US
dc.contributor.authorHuang, DPen_US
dc.contributor.authorJohnson, PJen_US
dc.date.accessioned2012-05-29T06:11:33Z-
dc.date.available2012-05-29T06:11:33Z-
dc.date.issued2000en_US
dc.identifier.citationCancer Research, 2000, v. 60 n. 24, p. 6878-6881en_US
dc.identifier.issn0008-5472en_US
dc.identifier.urihttp://hdl.handle.net/10722/148216-
dc.description.abstractWe investigated the prognostic implication of pretreatment plasma/ serum EBV DNA concentration, as measured by real-time quantitative PCR, in nasopharyngeal carcinoma (NPC). In 91 prospectively recruited NPC patients, those with recurrence or metastasis within the first year after treatment had a higher median plasma EBV DNA concentration than those without events (41,756 copies/ml versus 5,807 copies/ml; P < 0.001, Mann-Whitney rank-sum test). In multivariate logistic regression analysis, plasma EBV DNA was an independent prognostic indicator for early clinical events [relative risk = 3.8 (95% confidence interval, 1.6-9.2 for each 10-fold increase in plasma EBV DNA concentration; P = 0.003)]. In a second cohort of 139 NPC patients followed-up for a median period of 2,027 days (interquartile range, 597-2,335 days), serum EBV DNA was found to be a significant variable associated with NPC-related death in multivariate Cox's regression analysis [relative risk = 1.6 (95% confidence interval, 1.1-2.1 for each 10-fold increase in serum EBV DNA concentration; P = 0.007)]. The quantitation of circulating EBV DNA may thus allow improved prognostication of NPC.en_US
dc.languageengen_US
dc.publisherAmerican Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/en_US
dc.relation.ispartofCancer Researchen_US
dc.subject.meshAdulten_US
dc.subject.meshCarcinoma - Blood - Diagnosis - Genetics - Mortalityen_US
dc.subject.meshDna - Analysisen_US
dc.subject.meshFemaleen_US
dc.subject.meshHerpesvirus 4, Human - Genetics - Metabolismen_US
dc.subject.meshHumansen_US
dc.subject.meshLogistic Modelsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMultivariate Analysisen_US
dc.subject.meshNasopharyngeal Neoplasms - Blood - Diagnosis - Genetics - Mortalityen_US
dc.subject.meshPolymerase Chain Reactionen_US
dc.subject.meshPrognosisen_US
dc.subject.meshTime Factorsen_US
dc.titleMolecular prognostication of nasopharyngeal carcinoma by quantitative analysis of circulating epstein-barr virus DNAen_US
dc.typeArticleen_US
dc.identifier.emailLam, CW:ching-wanlam@pathology.hku.hken_US
dc.identifier.authorityLam, CW=rp00260en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid11156384-
dc.identifier.scopuseid_2-s2.0-0034671947en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034671947&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume60en_US
dc.identifier.issue24en_US
dc.identifier.spage6878en_US
dc.identifier.epage6881en_US
dc.identifier.isiWOS:000166201500023-
dc.publisher.placeUnited Statesen_US

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