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Article: Effects of antioxidants and a caspase inhibitor on chloramphenicol-induced toxicity of human bone marrow and HL-60 cells

TitleEffects of antioxidants and a caspase inhibitor on chloramphenicol-induced toxicity of human bone marrow and HL-60 cells
Authors
Issue Date2000
PublisherSage Publications Ltd. The Journal's web site is located at http://het.sagepub.com
Citation
Human And Experimental Toxicology, 2000, v. 19 n. 9, p. 503-510 How to Cite?
AbstractChloramphenicol (CAP), a board spectrum antibiotic widely used in many developing countries, has toxic side effects on bone marrow, the most serious of which is aplastic anemia. Recent studies suggest that effects of CAP on suppressing hematopoietic colony formation may be abrogated by antioxidants. In addition, there is preliminary evidence that CAP induces apoptosis in hemopoietic stem cells, leading to aplastic anemia. We have been unable to demonstrate the protective effects of a variety of antioxidants on CAP-induced suppression of burst-forming unit erythroid (BFU-E) and colony-forming unit granulocyte/monocyte (CFU-GM). Using flow cytometry, we have, however, confirmed that CAP can induce apoptosis in purified human bone marrow CD34 + cells. We also showed that a caspase inhibitor, Z-VAD.fmk, can ameliorate the apoptotic-inducing effects of CAP in the HL-60 cell line.
Persistent Identifierhttp://hdl.handle.net/10722/148213
ISSN
2015 Impact Factor: 1.604
2015 SCImago Journal Rankings: 0.569
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorKong, CTen_US
dc.contributor.authorHolt, DEen_US
dc.contributor.authorMa, SKen_US
dc.contributor.authorLie, AKWen_US
dc.contributor.authorChan, LCen_US
dc.date.accessioned2012-05-29T06:11:32Z-
dc.date.available2012-05-29T06:11:32Z-
dc.date.issued2000en_US
dc.identifier.citationHuman And Experimental Toxicology, 2000, v. 19 n. 9, p. 503-510en_US
dc.identifier.issn0960-3271en_US
dc.identifier.urihttp://hdl.handle.net/10722/148213-
dc.description.abstractChloramphenicol (CAP), a board spectrum antibiotic widely used in many developing countries, has toxic side effects on bone marrow, the most serious of which is aplastic anemia. Recent studies suggest that effects of CAP on suppressing hematopoietic colony formation may be abrogated by antioxidants. In addition, there is preliminary evidence that CAP induces apoptosis in hemopoietic stem cells, leading to aplastic anemia. We have been unable to demonstrate the protective effects of a variety of antioxidants on CAP-induced suppression of burst-forming unit erythroid (BFU-E) and colony-forming unit granulocyte/monocyte (CFU-GM). Using flow cytometry, we have, however, confirmed that CAP can induce apoptosis in purified human bone marrow CD34 + cells. We also showed that a caspase inhibitor, Z-VAD.fmk, can ameliorate the apoptotic-inducing effects of CAP in the HL-60 cell line.en_US
dc.languageengen_US
dc.publisherSage Publications Ltd. The Journal's web site is located at http://het.sagepub.comen_US
dc.relation.ispartofHuman and Experimental Toxicologyen_US
dc.subject.meshAmino Acid Chloromethyl Ketones - Pharmacologyen_US
dc.subject.meshAnti-Bacterial Agents - Toxicityen_US
dc.subject.meshAntigens, Cd34 - Analysisen_US
dc.subject.meshAntioxidants - Pharmacologyen_US
dc.subject.meshApoptosis - Drug Effectsen_US
dc.subject.meshBone Marrow Cells - Drug Effects - Immunology - Pathologyen_US
dc.subject.meshCaspases - Antagonists & Inhibitorsen_US
dc.subject.meshCell Cycle - Drug Effectsen_US
dc.subject.meshChloramphenicol - Toxicityen_US
dc.subject.meshCysteine Proteinase Inhibitors - Pharmacologyen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshErythroid Precursor Cells - Drug Effects - Immunology - Pathologyen_US
dc.subject.meshHl-60 Cells - Drug Effects - Pathologyen_US
dc.subject.meshHumansen_US
dc.titleEffects of antioxidants and a caspase inhibitor on chloramphenicol-induced toxicity of human bone marrow and HL-60 cellsen_US
dc.typeArticleen_US
dc.identifier.emailChan, LC:chanlc@hkucc.hku.hken_US
dc.identifier.authorityChan, LC=rp00373en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1191/096032700672635987en_US
dc.identifier.pmid11204552-
dc.identifier.scopuseid_2-s2.0-0034491059en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034491059&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume19en_US
dc.identifier.issue9en_US
dc.identifier.spage503en_US
dc.identifier.epage510en_US
dc.identifier.isiWOS:000166414800004-
dc.publisher.placeUnited Kingdomen_US

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