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Article: Cytogenetic triclonality in T-cell acute lymphoblastic leukemia: A conventional and molecular cytogenetic study

TitleCytogenetic triclonality in T-cell acute lymphoblastic leukemia: A conventional and molecular cytogenetic study
Authors
Issue Date2000
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergene
Citation
Cancer Genetics And Cytogenetics, 2000, v. 116 n. 1, p. 77-80 How to Cite?
AbstractCytogenetically-unrelated clones are infrequently seen in hematologic malignancies, and are particularly uncommon in acute lymphoblastic leukemia. We report a case of T-cell acute lymphoblastic leukemia with L2 morphology which demonstrated three cytogenetically distinct clones: 46,XY,t(2;9)(p21;q34)/46,XY,del(6)(q21q23)/47,XX,+8. Interphase cytogenetic analysis by fluorescence in situ hybridization (FISH) confirmed the presence of trisomy 8 in a significant proportion of lymphoblasts, while reverse transcription-polymerase chain reaction (RT-PCR) did not show the presence of BCR/ABL fusion. This is the first report describing the occurrence of cytogenetic triclonality in de novo T-cell acute lymphoblastic leukemia. Copyright (C) 1999 Elsevier Science Inc.
Persistent Identifierhttp://hdl.handle.net/10722/148195
ISSN
2012 Impact Factor: 1.929
2013 SCImago Journal Rankings: 0.872
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWong, KFen_US
dc.contributor.authorSo, CCen_US
dc.contributor.authorSiu, LPen_US
dc.date.accessioned2012-05-29T06:11:25Z-
dc.date.available2012-05-29T06:11:25Z-
dc.date.issued2000en_US
dc.identifier.citationCancer Genetics And Cytogenetics, 2000, v. 116 n. 1, p. 77-80en_US
dc.identifier.issn0165-4608en_US
dc.identifier.urihttp://hdl.handle.net/10722/148195-
dc.description.abstractCytogenetically-unrelated clones are infrequently seen in hematologic malignancies, and are particularly uncommon in acute lymphoblastic leukemia. We report a case of T-cell acute lymphoblastic leukemia with L2 morphology which demonstrated three cytogenetically distinct clones: 46,XY,t(2;9)(p21;q34)/46,XY,del(6)(q21q23)/47,XX,+8. Interphase cytogenetic analysis by fluorescence in situ hybridization (FISH) confirmed the presence of trisomy 8 in a significant proportion of lymphoblasts, while reverse transcription-polymerase chain reaction (RT-PCR) did not show the presence of BCR/ABL fusion. This is the first report describing the occurrence of cytogenetic triclonality in de novo T-cell acute lymphoblastic leukemia. Copyright (C) 1999 Elsevier Science Inc.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergeneen_US
dc.relation.ispartofCancer Genetics and Cytogeneticsen_US
dc.subject.meshChilden_US
dc.subject.meshChromosome Aberrationsen_US
dc.subject.meshChromosomes, Human, Pair 2en_US
dc.subject.meshChromosomes, Human, Pair 6en_US
dc.subject.meshChromosomes, Human, Pair 8en_US
dc.subject.meshChromosomes, Human, Pair 9en_US
dc.subject.meshCytogenetic Analysisen_US
dc.subject.meshGene Deletionen_US
dc.subject.meshGene Duplicationen_US
dc.subject.meshHumansen_US
dc.subject.meshIn Situ Hybridization, Fluorescenceen_US
dc.subject.meshKaryotypingen_US
dc.subject.meshLeukemia-Lymphoma, Adult T-Cell - Geneticsen_US
dc.subject.meshMaleen_US
dc.subject.meshReverse Transcriptase Polymerase Chain Reactionen_US
dc.subject.meshTranslocation, Geneticen_US
dc.titleCytogenetic triclonality in T-cell acute lymphoblastic leukemia: A conventional and molecular cytogenetic studyen_US
dc.typeArticleen_US
dc.identifier.emailSo, CC:scc@pathology.hku.hken_US
dc.identifier.authoritySo, CC=rp00391en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0165-4608(99)00096-5en_US
dc.identifier.pmid10616538-
dc.identifier.scopuseid_2-s2.0-0033991185en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033991185&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume116en_US
dc.identifier.issue1en_US
dc.identifier.spage77en_US
dc.identifier.epage80en_US
dc.identifier.isiWOS:000084136400016-
dc.publisher.placeUnited Statesen_US

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