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Article: Molecular characterization of der(15)t(11;15) as a secondary cytogenetic abnormality in acute promyelocytic leukemia with cryptic PML-RARα fusion on 17q

TitleMolecular characterization of der(15)t(11;15) as a secondary cytogenetic abnormality in acute promyelocytic leukemia with cryptic PML-RARα fusion on 17q
Authors
Wan, TSKMa, SKYip, SFYeung, YMChan, LC
Issue Date2000
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergene
Citation
Cancer Genetics And Cytogenetics, 2000, v. 121 n. 1, p. 90-93 How to Cite?
DOI: http://dx.doi.org/10.1016/S0165-4608(00)00234-X
AbstractA case of acute promyelocytic leukemia (APL) with cryptic PML-RARα fusion on 17q and add(15p) as a secondary abnormality was characterized using molecular cytogenetic techniques. Spectral karyotyping (SKY) showed that chromosome 11 material was added to 15p, forming a der(15)t(11;15), which was refined to der(15)t(11;15)(q13.2;p13) with information obtained by comparative genomic hybridization (CGH). Interstitial insertion of chromosome 15 material into chromosome 17q was found by fluorescence in situ hybridization (FISH) with whole chromosome painting (WCP) probes. This study illustrates the necessity of a combination of molecular cytogenetics to decipher complex karyotypic abnormalities and cryptic translocations in leukemia. (C) 2000 Elsevier Science Inc.
Persistent Identifierhttp://hdl.handle.net/10722/148187
ISSN
0165-4608
2012 Impact Factor: 1.929
ISI Accession Number ID
WOS:000088983400016
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorWan, TSKen_US
dc.contributor.authorMa, SKen_US
dc.contributor.authorYip, SFen_US
dc.contributor.authorYeung, YMen_US
dc.contributor.authorChan, LCen_US
dc.date.accessioned2012-05-29T06:11:21Z-
dc.date.available2012-05-29T06:11:21Z-
dc.date.issued2000en_US
dc.identifier.citationCancer Genetics And Cytogenetics, 2000, v. 121 n. 1, p. 90-93en_US
dc.identifier.issn0165-4608en_US
dc.identifier.urihttp://hdl.handle.net/10722/148187-
dc.description.abstractA case of acute promyelocytic leukemia (APL) with cryptic PML-RARα fusion on 17q and add(15p) as a secondary abnormality was characterized using molecular cytogenetic techniques. Spectral karyotyping (SKY) showed that chromosome 11 material was added to 15p, forming a der(15)t(11;15), which was refined to der(15)t(11;15)(q13.2;p13) with information obtained by comparative genomic hybridization (CGH). Interstitial insertion of chromosome 15 material into chromosome 17q was found by fluorescence in situ hybridization (FISH) with whole chromosome painting (WCP) probes. This study illustrates the necessity of a combination of molecular cytogenetics to decipher complex karyotypic abnormalities and cryptic translocations in leukemia. (C) 2000 Elsevier Science Inc.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergeneen_US
dc.relation.ispartofCancer Genetics and Cytogeneticsen_US
dc.subject.meshChromosomes, Human, Pair 11 - Geneticsen_US
dc.subject.meshChromosomes, Human, Pair 15 - Geneticsen_US
dc.subject.meshChromosomes, Human, Pair 17 - Geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshIn Situ Hybridization, Fluorescenceen_US
dc.subject.meshKaryotypingen_US
dc.subject.meshLeukemia, Promyelocytic, Acute - Geneticsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNeoplasm Proteins - Geneticsen_US
dc.subject.meshNucleic Acid Hybridizationen_US
dc.subject.meshOncogene Proteins, Fusion - Geneticsen_US
dc.subject.meshTranslocation, Genetic - Geneticsen_US
dc.titleMolecular characterization of der(15)t(11;15) as a secondary cytogenetic abnormality in acute promyelocytic leukemia with cryptic PML-RARα fusion on 17qen_US
dc.typeArticleen_US
dc.identifier.emailChan, LC:chanlc@hkucc.hku.hken_US
dc.identifier.authorityChan, LC=rp00373en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0165-4608(00)00234-Xen_US
dc.identifier.pmid10958948-
dc.identifier.scopuseid_2-s2.0-0033839263en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033839263&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume121en_US
dc.identifier.issue1en_US
dc.identifier.spage90en_US
dc.identifier.epage93en_US
dc.identifier.isiWOS:000088983400016-
dc.publisher.placeUnited Statesen_US
dc.identifier.issnl0165-4608-

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