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Article: Complex variant 15;17 translocations in acute promyelocytic leukemia: A case report and review of three-way translocations

TitleComplex variant 15;17 translocations in acute promyelocytic leukemia: A case report and review of three-way translocations
Authors
Issue Date1999
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergene
Citation
Cancer Genetics And Cytogenetics, 1999, v. 111 n. 2, p. 139-143 How to Cite?
AbstractComplex variant 15;17 translocations are increasingly recognized in acute promyelocytic leukemia (APL). We report a novel three-way translocation in APL involving chromosomes 15, 17, and X in the form of t(X;17;15)(q13;q12;q21). Southern blot analysis showed retinoic acid receptor α (RARA) gene rearrangement at intron 2. Clinical and morphologic findings are typical of APL, and a complete remission was attained with a course of conventional chemotherapy. A review of three-way complex variants of 15;17 translocation in the literature reveals 21 published cases in addition to ours. PML/RARA fusion was observed in all 8 cases in which molecular genetic analysis had been performed. More cases need to be analyzed to determine if clustering to particular chromosomal bands occurs in variant translocations, and whether APL cases harboring complex 15;17 variants differ clinically from those with classical 15;17 translocation.
Persistent Identifierhttp://hdl.handle.net/10722/148156
ISSN
2012 Impact Factor: 1.929
2013 SCImago Journal Rankings: 0.872
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWan, TSKen_HK
dc.contributor.authorChim, CSen_HK
dc.contributor.authorSo, CKen_HK
dc.contributor.authorChan, LCen_HK
dc.contributor.authorMa, SKen_HK
dc.date.accessioned2012-05-29T06:11:09Z-
dc.date.available2012-05-29T06:11:09Z-
dc.date.issued1999en_HK
dc.identifier.citationCancer Genetics And Cytogenetics, 1999, v. 111 n. 2, p. 139-143en_HK
dc.identifier.issn0165-4608en_HK
dc.identifier.urihttp://hdl.handle.net/10722/148156-
dc.description.abstractComplex variant 15;17 translocations are increasingly recognized in acute promyelocytic leukemia (APL). We report a novel three-way translocation in APL involving chromosomes 15, 17, and X in the form of t(X;17;15)(q13;q12;q21). Southern blot analysis showed retinoic acid receptor α (RARA) gene rearrangement at intron 2. Clinical and morphologic findings are typical of APL, and a complete remission was attained with a course of conventional chemotherapy. A review of three-way complex variants of 15;17 translocation in the literature reveals 21 published cases in addition to ours. PML/RARA fusion was observed in all 8 cases in which molecular genetic analysis had been performed. More cases need to be analyzed to determine if clustering to particular chromosomal bands occurs in variant translocations, and whether APL cases harboring complex 15;17 variants differ clinically from those with classical 15;17 translocation.en_HK
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergeneen_HK
dc.relation.ispartofCancer Genetics and Cytogeneticsen_HK
dc.rightsCancer Genetics and Cytogenetics. Copyright © Elsevier Inc.-
dc.subject.meshAdulten_US
dc.subject.meshAntineoplastic Combined Chemotherapy Protocols - Pharmacologyen_US
dc.subject.meshBlotting, Southernen_US
dc.subject.meshChromosomes, Human, Pair 15en_US
dc.subject.meshChromosomes, Human, Pair 17en_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshKaryotypingen_US
dc.subject.meshLeukemia, Promyelocytic, Acute - Drug Therapy - Geneticsen_US
dc.subject.meshNeoplasm Proteins - Geneticsen_US
dc.subject.meshOncogene Proteins, Fusion - Geneticsen_US
dc.subject.meshReceptors, Retinoic Acid - Geneticsen_US
dc.subject.meshTranslocation, Geneticen_US
dc.subject.meshX Chromosomeen_US
dc.titleComplex variant 15;17 translocations in acute promyelocytic leukemia: A case report and review of three-way translocationsen_HK
dc.typeArticleen_HK
dc.identifier.emailChim, CS:jcschim@hku.hken_HK
dc.identifier.emailChan, LC:chanlc@hkucc.hku.hken_HK
dc.identifier.authorityChim, CS=rp00408en_HK
dc.identifier.authorityChan, LC=rp00373en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0165-4608(98)00230-1en_HK
dc.identifier.pmid10347551-
dc.identifier.scopuseid_2-s2.0-0032900687en_HK
dc.identifier.hkuros41691-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032900687&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume111en_HK
dc.identifier.issue2en_HK
dc.identifier.spage139en_HK
dc.identifier.epage143en_HK
dc.identifier.isiWOS:000080342100007-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridWan, TSK=25623981600en_HK
dc.identifier.scopusauthoridChim, CS=7004597253en_HK
dc.identifier.scopusauthoridSo, CK=7102919975en_HK
dc.identifier.scopusauthoridChan, LC=7403540707en_HK
dc.identifier.scopusauthoridMa, SK=9042504200en_HK

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