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Article: BCR/ABL translocation in adult acute lymphoblastic leukemia: A comparison of conventional and interphase cytogenetic studies

TitleBCR/ABL translocation in adult acute lymphoblastic leukemia: A comparison of conventional and interphase cytogenetic studies
Authors
Issue Date1999
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergene
Citation
Cancer Genetics And Cytogenetics, 1999, v. 110 n. 1, p. 19-22 How to Cite?
AbstractTwenty-four adult Chinese patients with do nova acute lymphoblastic leukemia (ALL) were studied for the BCR/ABL translocation using both conventional cytogenetics and fluorescence in situ hybridization (FISH). Eight (33%) patients had the translocation as shown by FISH and all were B- lineage ALL (8/19, 42%). Conventional cytogenetics revealed a t(9;22)(q34;q11) in six of them, but was either unsuccessful or not done in the other two. Seven of the eight positive cases (88%) showed a breakpoint at the minor breakpoint cluster region (m-BCR), which was confirmed by reverse transcriptase polymerase chain reaction (RT-PCR). To conclude, the frequency of BCR/ABL translocation in Chinese patients with de nova ALL is comparable to patients in the Western hemisphere, in contrast to a previous report. The predominance of m-BCR/ABL fusion among these Chinese patients with BCR/ABL translocation is also similar to patients in the Western population. Fluorescence in situ hybridization is a sensitive, specific and relatively simple technique for demonstrating this important unfavorable prognostic marker in ALL, even in a routine service laboratory setting.
Persistent Identifierhttp://hdl.handle.net/10722/148155
ISSN
2012 Impact Factor: 1.929
2013 SCImago Journal Rankings: 0.872
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSo, CCen_HK
dc.contributor.authorWong, KFen_HK
dc.contributor.authorChung, Jen_HK
dc.contributor.authorKwong, YLen_HK
dc.date.accessioned2012-05-29T06:11:09Z-
dc.date.available2012-05-29T06:11:09Z-
dc.date.issued1999en_HK
dc.identifier.citationCancer Genetics And Cytogenetics, 1999, v. 110 n. 1, p. 19-22en_HK
dc.identifier.issn0165-4608en_HK
dc.identifier.urihttp://hdl.handle.net/10722/148155-
dc.description.abstractTwenty-four adult Chinese patients with do nova acute lymphoblastic leukemia (ALL) were studied for the BCR/ABL translocation using both conventional cytogenetics and fluorescence in situ hybridization (FISH). Eight (33%) patients had the translocation as shown by FISH and all were B- lineage ALL (8/19, 42%). Conventional cytogenetics revealed a t(9;22)(q34;q11) in six of them, but was either unsuccessful or not done in the other two. Seven of the eight positive cases (88%) showed a breakpoint at the minor breakpoint cluster region (m-BCR), which was confirmed by reverse transcriptase polymerase chain reaction (RT-PCR). To conclude, the frequency of BCR/ABL translocation in Chinese patients with de nova ALL is comparable to patients in the Western hemisphere, in contrast to a previous report. The predominance of m-BCR/ABL fusion among these Chinese patients with BCR/ABL translocation is also similar to patients in the Western population. Fluorescence in situ hybridization is a sensitive, specific and relatively simple technique for demonstrating this important unfavorable prognostic marker in ALL, even in a routine service laboratory setting.en_HK
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergeneen_HK
dc.relation.ispartofCancer Genetics and Cytogeneticsen_HK
dc.rightsCancer Genetics and Cytogenetics. Copyright © Elsevier Inc.-
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshFemaleen_US
dc.subject.meshFusion Proteins, Bcr-Abl - Geneticsen_US
dc.subject.meshGenes, Ablen_US
dc.subject.meshHumansen_US
dc.subject.meshInterphaseen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshOncogene Proteins - Geneticsen_US
dc.subject.meshPrecursor Cell Lymphoblastic Leukemia-Lymphoma - Geneticsen_US
dc.subject.meshProtein-Tyrosine Kinasesen_US
dc.subject.meshProto-Oncogene Proteinsen_US
dc.subject.meshProto-Oncogene Proteins C-Bcren_US
dc.subject.meshTranslocation, Geneticen_US
dc.titleBCR/ABL translocation in adult acute lymphoblastic leukemia: A comparison of conventional and interphase cytogenetic studiesen_HK
dc.typeArticleen_HK
dc.identifier.emailSo, CC:scc@pathology.hku.hken_HK
dc.identifier.emailKwong, YL:ylkwong@hku.hken_HK
dc.identifier.authoritySo, CC=rp00391en_HK
dc.identifier.authorityKwong, YL=rp00358en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0165-4608(98)00184-8en_HK
dc.identifier.pmid10198617-
dc.identifier.scopuseid_2-s2.0-0032897329en_HK
dc.identifier.hkuros41971-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032897329&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume110en_HK
dc.identifier.issue1en_HK
dc.identifier.spage19en_HK
dc.identifier.epage22en_HK
dc.identifier.isiWOS:000079485600004-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridSo, CC=7102919978en_HK
dc.identifier.scopusauthoridWong, KF=7404759860en_HK
dc.identifier.scopusauthoridChung, J=8834575100en_HK
dc.identifier.scopusauthoridKwong, YL=7102818954en_HK

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