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Article: Molecular pathology and clinicopathologic features of penile tumors: With special reference to analyses of p21 and p53 expression and unusual histologic features

TitleMolecular pathology and clinicopathologic features of penile tumors: With special reference to analyses of p21 and p53 expression and unusual histologic features
Authors
Issue Date1999
Citation
Archives Of Pathology And Laboratory Medicine, 1999, v. 123 n. 10, p. 895-904 How to Cite?
AbstractObjectives. - To examine the histologic features of p21 in penile tumors and to determine the role of p21 and p53 in the pathogenesis of this group of tumors. Methods. - The clinicopathologic features of 87 patients with penile tumors were studied. The expression of p53 and p21 proteins in 49 cases was investigated by immunohistochemistry. Results. - Of the 87 tumors studied, 84 represented primary penile tumors (72 malignant and 12 benign) and 3 represented secondary tumors (2 from bladder, 1 from nasopharynx). The primary malignant penile tumors included 66 surface carcinomas with squamous differentiation (92%), 3 cases of Paget disease (4%), 1 case of Bowen disease (1%), and 2 penile urethral squamous cell carcinomas (3%). The former group was subdivided into squamous cell carcinoma (n = 50), verrucous carcinoma (n = 8), basaloid squamous cell carcinoma (n = 3), adenoid squamous cell carcinoma (n = 3), spindle cell carcinoma (n = 1), and adenosquamous carcinoma (n = 1). The benign tumors were squamous cell papillomas (n = 10) and fibromatoses (n = 2). Expression of p21 and p53 was noted in 40% and 89%, respectively, of the 47 patients with primary surface penile carcinoma with squamous differentiation. Positive p21 and p53 expression was also seen in 2 cases of Paget disease. Staining for p21 was often weak and was found in the suprabasal region of carcinomas with squamous differentiation, while p53 expression was seen in the basal region of squamous cell carcinomas. Preinvasive lesions also showed p21 and p53 expression. An inverse correlation between p53 and p21 expression (p53+/p21- or p53-/p21+) was noted in half of the squamous cell carcinomas, 4 of 5 verrucous carcinomas, 2 of 3 basaloid squamous cell carcinomas, and in 1 spindle cell carcinoma. The other cases did not show this correlation. Conclusions. - Penile tumors had different histologic variants and p21/p53 expression patterns. Expression of p21 did play a role in some tumors and could be dependent or independent of p53 expression.
Persistent Identifierhttp://hdl.handle.net/10722/148149
ISSN
2015 Impact Factor: 2.631
2015 SCImago Journal Rankings: 1.158
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLam, KYen_US
dc.contributor.authorChan, KWen_US
dc.date.accessioned2012-05-29T06:11:07Z-
dc.date.available2012-05-29T06:11:07Z-
dc.date.issued1999en_US
dc.identifier.citationArchives Of Pathology And Laboratory Medicine, 1999, v. 123 n. 10, p. 895-904en_US
dc.identifier.issn0003-9985en_US
dc.identifier.urihttp://hdl.handle.net/10722/148149-
dc.description.abstractObjectives. - To examine the histologic features of p21 in penile tumors and to determine the role of p21 and p53 in the pathogenesis of this group of tumors. Methods. - The clinicopathologic features of 87 patients with penile tumors were studied. The expression of p53 and p21 proteins in 49 cases was investigated by immunohistochemistry. Results. - Of the 87 tumors studied, 84 represented primary penile tumors (72 malignant and 12 benign) and 3 represented secondary tumors (2 from bladder, 1 from nasopharynx). The primary malignant penile tumors included 66 surface carcinomas with squamous differentiation (92%), 3 cases of Paget disease (4%), 1 case of Bowen disease (1%), and 2 penile urethral squamous cell carcinomas (3%). The former group was subdivided into squamous cell carcinoma (n = 50), verrucous carcinoma (n = 8), basaloid squamous cell carcinoma (n = 3), adenoid squamous cell carcinoma (n = 3), spindle cell carcinoma (n = 1), and adenosquamous carcinoma (n = 1). The benign tumors were squamous cell papillomas (n = 10) and fibromatoses (n = 2). Expression of p21 and p53 was noted in 40% and 89%, respectively, of the 47 patients with primary surface penile carcinoma with squamous differentiation. Positive p21 and p53 expression was also seen in 2 cases of Paget disease. Staining for p21 was often weak and was found in the suprabasal region of carcinomas with squamous differentiation, while p53 expression was seen in the basal region of squamous cell carcinomas. Preinvasive lesions also showed p21 and p53 expression. An inverse correlation between p53 and p21 expression (p53+/p21- or p53-/p21+) was noted in half of the squamous cell carcinomas, 4 of 5 verrucous carcinomas, 2 of 3 basaloid squamous cell carcinomas, and in 1 spindle cell carcinoma. The other cases did not show this correlation. Conclusions. - Penile tumors had different histologic variants and p21/p53 expression patterns. Expression of p21 did play a role in some tumors and could be dependent or independent of p53 expression.en_US
dc.languageengen_US
dc.relation.ispartofArchives of Pathology and Laboratory Medicineen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshCarcinoma, Adenosquamous - Classification - Metabolism - Pathologyen_US
dc.subject.meshCarcinoma, Squamous Cell - Classification - Metabolism - Pathologyen_US
dc.subject.meshCarcinoma, Transitional Cell - Classification - Metabolism - Pathologyen_US
dc.subject.meshCyclin-Dependent Kinase Inhibitor P21en_US
dc.subject.meshCyclins - Metabolismen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunoenzyme Techniquesen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNeoplasm Stagingen_US
dc.subject.meshPenile Neoplasms - Classification - Metabolism - Pathologyen_US
dc.subject.meshTumor Suppressor Protein P53 - Metabolismen_US
dc.titleMolecular pathology and clinicopathologic features of penile tumors: With special reference to analyses of p21 and p53 expression and unusual histologic featuresen_US
dc.typeArticleen_US
dc.identifier.emailChan, KW:hrmtckw@hku.hken_US
dc.identifier.authorityChan, KW=rp00330en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid10506441en_US
dc.identifier.scopuseid_2-s2.0-0032860973en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032860973&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume123en_US
dc.identifier.issue10en_US
dc.identifier.spage895en_US
dc.identifier.epage904en_US
dc.identifier.isiWOS:000083152300007-

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