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Article: Cytogenetic divergence of the same blastic clone in transformed chronic granulocytic leukemia: No effect on morphologic and immunologic features

TitleCytogenetic divergence of the same blastic clone in transformed chronic granulocytic leukemia: No effect on morphologic and immunologic features
Authors
Wong, KFSo, CCKwong, YL
Issue Date1999
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergene
Citation
Cancer Genetics And Cytogenetics, 1999, v. 113 n. 1, p. 54-57 How to Cite?
DOI: http://dx.doi.org/10.1016/S0165-4608(99)00004-7
AbstractA 19-year-old man with Ph-positive chronic granulocytic leukemia developed lymphoblastic transformation. Cytogenetic evolution was observed, with an abnormal clone showing i(17q) together with the t(9;22). Chronic phase of the chronic granulocytic leukemia were re-established with systemic chemotherapy, which also led to disappearance of the clone with i(17q). However, the acute lymphoblastic leukemia relapsed after 6 weeks, with the emergence of a phenotypically and genetically identical but cytogenetically distinctive clone. Our findings suggest that cytogenetic evolution in transformed chronic granulocytic leukemia reflects only the instability of the blastic clones, and may not determine its phenotypic differentiation. Copyright (C) 1999 Elsevier Science Inc.
Persistent Identifierhttp://hdl.handle.net/10722/148145
ISSN
0165-4608
2012 Impact Factor: 1.929
ISI Accession Number ID
WOS:000082050300010
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorWong, KFen_HK
dc.contributor.authorSo, CCen_HK
dc.contributor.authorKwong, YLen_HK
dc.date.accessioned2012-05-29T06:11:06Z-
dc.date.available2012-05-29T06:11:06Z-
dc.date.issued1999en_HK
dc.identifier.citationCancer Genetics And Cytogenetics, 1999, v. 113 n. 1, p. 54-57en_HK
dc.identifier.issn0165-4608en_HK
dc.identifier.urihttp://hdl.handle.net/10722/148145-
dc.description.abstractA 19-year-old man with Ph-positive chronic granulocytic leukemia developed lymphoblastic transformation. Cytogenetic evolution was observed, with an abnormal clone showing i(17q) together with the t(9;22). Chronic phase of the chronic granulocytic leukemia were re-established with systemic chemotherapy, which also led to disappearance of the clone with i(17q). However, the acute lymphoblastic leukemia relapsed after 6 weeks, with the emergence of a phenotypically and genetically identical but cytogenetically distinctive clone. Our findings suggest that cytogenetic evolution in transformed chronic granulocytic leukemia reflects only the instability of the blastic clones, and may not determine its phenotypic differentiation. Copyright (C) 1999 Elsevier Science Inc.en_HK
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergeneen_HK
dc.relation.ispartofCancer Genetics and Cytogeneticsen_HK
dc.rightsCancer Genetics and Cytogenetics. Copyright © Elsevier Inc.-
dc.subject.meshAdulten_US
dc.subject.meshBlast Crisis - Geneticsen_US
dc.subject.meshChromosome Deletionen_US
dc.subject.meshChromosomes, Human, Pair 1en_US
dc.subject.meshChromosomes, Human, Pair 17en_US
dc.subject.meshChromosomes, Human, Pair 3en_US
dc.subject.meshClone Cellsen_US
dc.subject.meshHumansen_US
dc.subject.meshKaryotypingen_US
dc.subject.meshLeukemia, Myelogenous, Chronic, Bcr-Abl Positive - Genetics - Immunology - Pathologyen_US
dc.subject.meshLymphocyte Activation - Geneticsen_US
dc.subject.meshMaleen_US
dc.subject.meshRecurrenceen_US
dc.subject.meshTranslocation, Geneticen_US
dc.titleCytogenetic divergence of the same blastic clone in transformed chronic granulocytic leukemia: No effect on morphologic and immunologic featuresen_HK
dc.typeArticleen_HK
dc.identifier.emailSo, CC:scc@pathology.hku.hken_HK
dc.identifier.emailKwong, YL:ylkwong@hku.hken_HK
dc.identifier.authoritySo, CC=rp00391en_HK
dc.identifier.authorityKwong, YL=rp00358en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0165-4608(99)00004-7en_HK
dc.identifier.pmid10459347-
dc.identifier.scopuseid_2-s2.0-0032854808en_HK
dc.identifier.hkuros49578-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032854808&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume113en_HK
dc.identifier.issue1en_HK
dc.identifier.spage54en_HK
dc.identifier.epage57en_HK
dc.identifier.isiWOS:000082050300010-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridWong, KF=7404759860en_HK
dc.identifier.scopusauthoridSo, CC=7102919978en_HK
dc.identifier.scopusauthoridKwong, YL=7102818954en_HK
dc.identifier.issnl0165-4608-

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