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Article: Trisomy 5 in two cases of acute monocytic leukemia with hyperdiploid clones

TitleTrisomy 5 in two cases of acute monocytic leukemia with hyperdiploid clones
Authors
Issue Date1998
PublisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/leukres
Citation
Leukemia Research, 1998, v. 22 n. 10, p. 961-964 How to Cite?
AbstractAlthough numerical chromosomal aberrations are commonly seen in acute myeloid leukemia (AML), trisomy 5 (+ 5) is very rarely detected. We report two patients, both of whom suffered from acute monocytic leukemia, in which + 5 was found in hyperdiploid clones. A review of the English literature shows 17 additional cases of AML with + 5 in at least one of the abnormal clones, making a total of 19 such cases including ours. Trisomy 5 has been reported in all FAB subtypes of AML except acute promyelocytic leukemia. In the 19 cases identified in this report, + 5 was found in association with other numerical changes (four cases), structural changes (five cases) or both (eight cases). Trisomy 5 as a sole karyotypic abnormality was exceedingly rare (two cases). Its biologic and prognostic significance remains to be determined.
Persistent Identifierhttp://hdl.handle.net/10722/148131
ISSN
2015 Impact Factor: 2.606
2015 SCImago Journal Rankings: 1.043
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMa, SKen_US
dc.contributor.authorWan, TSKen_US
dc.contributor.authorAu, WYen_US
dc.contributor.authorChan, LCen_US
dc.date.accessioned2012-05-29T06:11:02Z-
dc.date.available2012-05-29T06:11:02Z-
dc.date.issued1998en_US
dc.identifier.citationLeukemia Research, 1998, v. 22 n. 10, p. 961-964en_US
dc.identifier.issn0145-2126en_US
dc.identifier.urihttp://hdl.handle.net/10722/148131-
dc.description.abstractAlthough numerical chromosomal aberrations are commonly seen in acute myeloid leukemia (AML), trisomy 5 (+ 5) is very rarely detected. We report two patients, both of whom suffered from acute monocytic leukemia, in which + 5 was found in hyperdiploid clones. A review of the English literature shows 17 additional cases of AML with + 5 in at least one of the abnormal clones, making a total of 19 such cases including ours. Trisomy 5 has been reported in all FAB subtypes of AML except acute promyelocytic leukemia. In the 19 cases identified in this report, + 5 was found in association with other numerical changes (four cases), structural changes (five cases) or both (eight cases). Trisomy 5 as a sole karyotypic abnormality was exceedingly rare (two cases). Its biologic and prognostic significance remains to be determined.en_US
dc.languageengen_US
dc.publisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/leukresen_US
dc.relation.ispartofLeukemia Researchen_US
dc.subject.meshAdulten_US
dc.subject.meshChromosomes, Human, Pair 5en_US
dc.subject.meshClone Cellsen_US
dc.subject.meshDiploidyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshLeukemia, Monocytic, Acute - Geneticsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshTrisomyen_US
dc.titleTrisomy 5 in two cases of acute monocytic leukemia with hyperdiploid clonesen_US
dc.typeArticleen_US
dc.identifier.emailChan, LC:chanlc@hkucc.hku.hken_US
dc.identifier.authorityChan, LC=rp00373en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0145-2126(98)00095-2en_US
dc.identifier.pmid9766757-
dc.identifier.scopuseid_2-s2.0-0032191480en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032191480&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume22en_US
dc.identifier.issue10en_US
dc.identifier.spage961en_US
dc.identifier.epage964en_US
dc.identifier.isiWOS:000075963800014-
dc.publisher.placeUnited Kingdomen_US

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