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Article: Robertsonian translocation as an acquired karyotypic abnormality in leukaemia

TitleRobertsonian translocation as an acquired karyotypic abnormality in leukaemia
Authors
Issue Date1997
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJH
Citation
British Journal Of Haematology, 1997, v. 98 n. 1, p. 213-215 How to Cite?
AbstractRobertsonian translocations, although relatively common as a constitutional genetic aberration, are rarely encountered in leukaemia. We report a case of acute myeloid leukaemia which showed an acquired Robertsonian translocation in the form of der(14;21) by cytogenetic analysis of leukaemic cells. This was confirmed by the PHA-stimulated culture of peripheral blood lymphocytes. A review of the literature identifies only eight reported cases of acquired Robertsonian translocations in leukaemia. In the majority of cases the Robertsonian translocation occurs as a secondary change in a complex abnormal clone, whereas in two out of nine patients reported, including ours, it is found as a sole karyotypic abnormality.
Persistent Identifierhttp://hdl.handle.net/10722/148075
ISSN
2015 Impact Factor: 5.401
2015 SCImago Journal Rankings: 2.313
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMa, SKen_US
dc.contributor.authorChow, EYDen_US
dc.contributor.authorWan, TSKen_US
dc.contributor.authorChan, LCen_US
dc.date.accessioned2012-05-29T06:10:43Z-
dc.date.available2012-05-29T06:10:43Z-
dc.date.issued1997en_US
dc.identifier.citationBritish Journal Of Haematology, 1997, v. 98 n. 1, p. 213-215en_US
dc.identifier.issn0007-1048en_US
dc.identifier.urihttp://hdl.handle.net/10722/148075-
dc.description.abstractRobertsonian translocations, although relatively common as a constitutional genetic aberration, are rarely encountered in leukaemia. We report a case of acute myeloid leukaemia which showed an acquired Robertsonian translocation in the form of der(14;21) by cytogenetic analysis of leukaemic cells. This was confirmed by the PHA-stimulated culture of peripheral blood lymphocytes. A review of the literature identifies only eight reported cases of acquired Robertsonian translocations in leukaemia. In the majority of cases the Robertsonian translocation occurs as a secondary change in a complex abnormal clone, whereas in two out of nine patients reported, including ours, it is found as a sole karyotypic abnormality.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJHen_US
dc.relation.ispartofBritish Journal of Haematologyen_US
dc.subject.meshAcute Diseaseen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAntineoplastic Combined Chemotherapy Protocols - Therapeutic Useen_US
dc.subject.meshChromosomes, Human, Pair 14 - Geneticsen_US
dc.subject.meshChromosomes, Human, Pair 21 - Geneticsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshKaryotypingen_US
dc.subject.meshLeukemia, Myeloid - Drug Therapy - Geneticsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshTranslocation, Geneticen_US
dc.titleRobertsonian translocation as an acquired karyotypic abnormality in leukaemiaen_US
dc.typeArticleen_US
dc.identifier.emailChan, LC:chanlc@hkucc.hku.hken_US
dc.identifier.authorityChan, LC=rp00373en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid9233587-
dc.identifier.scopuseid_2-s2.0-0030793474en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030793474&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume98en_US
dc.identifier.issue1en_US
dc.identifier.spage213en_US
dc.identifier.epage215en_US
dc.identifier.isiWOS:A1997XL57800033-
dc.publisher.placeUnited Kingdomen_US

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