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Article: Acute myeloid leukemia following psoralen with ultraviolet A therapy: A fluorescence in situ hybridization study

TitleAcute myeloid leukemia following psoralen with ultraviolet A therapy: A fluorescence in situ hybridization study
Authors
Issue Date1997
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergene
Citation
Cancer Genetics And Cytogenetics, 1997, v. 99 n. 1, p. 11-13 How to Cite?
AbstractA woman with mycosis fungoides treated by psoralen with ultraviolet A (PUVA) and electron beam therapy developed acute myeloid leukemia (AML) three years later. Karyotypic analysis of the leukemia cells revealed monosomy 7. Fluorescence in situ hybridization showed that the monosomy 7 clone had accounted for about a third of the marrow cells after PUVA treatment, but replaced the entire marrow at leukemic transformation. These findings were consistent with a secondary AML evolving from an underlying myelodysplasia, supporting that PUVA therapy might have a mutagenic effect on hematopoietic cells. This might be related to its effect on circulating hematopoietic stem cells.
Persistent Identifierhttp://hdl.handle.net/10722/148069
ISSN
2012 Impact Factor: 1.929
2013 SCImago Journal Rankings: 0.872
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorKwong, YLen_HK
dc.contributor.authorAu, WYen_HK
dc.contributor.authorNg, MHLen_HK
dc.contributor.authorChan, LCen_HK
dc.contributor.authorAu, TSen_HK
dc.date.accessioned2012-05-29T06:10:41Z-
dc.date.available2012-05-29T06:10:41Z-
dc.date.issued1997en_HK
dc.identifier.citationCancer Genetics And Cytogenetics, 1997, v. 99 n. 1, p. 11-13en_HK
dc.identifier.issn0165-4608en_HK
dc.identifier.urihttp://hdl.handle.net/10722/148069-
dc.description.abstractA woman with mycosis fungoides treated by psoralen with ultraviolet A (PUVA) and electron beam therapy developed acute myeloid leukemia (AML) three years later. Karyotypic analysis of the leukemia cells revealed monosomy 7. Fluorescence in situ hybridization showed that the monosomy 7 clone had accounted for about a third of the marrow cells after PUVA treatment, but replaced the entire marrow at leukemic transformation. These findings were consistent with a secondary AML evolving from an underlying myelodysplasia, supporting that PUVA therapy might have a mutagenic effect on hematopoietic cells. This might be related to its effect on circulating hematopoietic stem cells.en_HK
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergeneen_HK
dc.relation.ispartofCancer Genetics and Cytogeneticsen_HK
dc.rightsCancer Genetics and Cytogenetics. Copyright © Elsevier Inc.-
dc.subject.meshChromosomes, Human, Pair 7en_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshIn Situ Hybridization, Fluorescenceen_US
dc.subject.meshLeukemia, Myeloid, Acute - Chemically Induced - Geneticsen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMonosomyen_US
dc.subject.meshMycosis Fungoides - Drug Therapy - Radiotherapyen_US
dc.subject.meshPuva Therapy - Adverse Effectsen_US
dc.titleAcute myeloid leukemia following psoralen with ultraviolet A therapy: A fluorescence in situ hybridization studyen_HK
dc.typeArticleen_HK
dc.identifier.emailKwong, YL:ylkwong@hku.hken_HK
dc.identifier.emailChan, LC:chanlc@hkucc.hku.hken_HK
dc.identifier.authorityKwong, YL=rp00358en_HK
dc.identifier.authorityChan, LC=rp00373en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0165-4608(96)00429-3en_HK
dc.identifier.pmid9352789-
dc.identifier.scopuseid_2-s2.0-0030728424en_HK
dc.identifier.hkuros33222-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030728424&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume99en_HK
dc.identifier.issue1en_HK
dc.identifier.spage11en_HK
dc.identifier.epage13en_HK
dc.identifier.isiWOS:A1997YC66200002-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridKwong, YL=7102818954en_HK
dc.identifier.scopusauthoridAu, WY=7202383089en_HK
dc.identifier.scopusauthoridNg, MHL=35292609300en_HK
dc.identifier.scopusauthoridChan, LC=7403540707en_HK
dc.identifier.scopusauthoridAu, TS=55225059900en_HK

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