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Article: Analysis of L-myc and GSTM1 genotypes in Chinese non-small cell lung carcinoma patients

TitleAnalysis of L-myc and GSTM1 genotypes in Chinese non-small cell lung carcinoma patients
Authors
Keywordsgenotype
GST
L-myc
lung cancer
Issue Date1996
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/lungcan
Citation
Lung Cancer, 1996, v. 15 n. 3, p. 355-366 How to Cite?
AbstractThe genotypes of L-myc and GSTM1 genes were studied in normal lung tissues of 98 non-small cell lung carcinoma (NSCLC) patients from Hong Kong using polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) techniques. Results showed a statistical difference in L-myc genotypes between Chinese and African Americans (P = 0.02). A significant deficit in heterozygotes resulting in the departure from Hardy-Weinberg equilibrium in lung cancer female patients was detected (0.01 < P < 0.02). There were significant differences in survival times in patients having L-L and S-S genotypes, with shorter survival times in the patients with L-L genotypes (0.01 < P < 0.05). Data on age, size of tumor, histological types, and lymph node metastasis showed no significant association with L-myc genotype. The survival time in the GSTM1-negative (null gene) group was significantly different from the GSTM1 positive group between 16 and 24 months after operation (0.01 < P < 0.05). There was no significant difference in the distribution of GSTM1 genotypes between Chinese and Caucasian Americans.
Persistent Identifierhttp://hdl.handle.net/10722/148063
ISSN
2015 Impact Factor: 3.767
2015 SCImago Journal Rankings: 1.923
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorGe, Hen_HK
dc.contributor.authorLam, WKen_HK
dc.contributor.authorLee, Jen_HK
dc.contributor.authorWong, MPen_HK
dc.contributor.authorYew, WWen_HK
dc.contributor.authorLung, MLen_HK
dc.date.accessioned2012-05-29T06:10:39Z-
dc.date.available2012-05-29T06:10:39Z-
dc.date.issued1996en_HK
dc.identifier.citationLung Cancer, 1996, v. 15 n. 3, p. 355-366en_HK
dc.identifier.issn0169-5002en_HK
dc.identifier.urihttp://hdl.handle.net/10722/148063-
dc.description.abstractThe genotypes of L-myc and GSTM1 genes were studied in normal lung tissues of 98 non-small cell lung carcinoma (NSCLC) patients from Hong Kong using polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) techniques. Results showed a statistical difference in L-myc genotypes between Chinese and African Americans (P = 0.02). A significant deficit in heterozygotes resulting in the departure from Hardy-Weinberg equilibrium in lung cancer female patients was detected (0.01 < P < 0.02). There were significant differences in survival times in patients having L-L and S-S genotypes, with shorter survival times in the patients with L-L genotypes (0.01 < P < 0.05). Data on age, size of tumor, histological types, and lymph node metastasis showed no significant association with L-myc genotype. The survival time in the GSTM1-negative (null gene) group was significantly different from the GSTM1 positive group between 16 and 24 months after operation (0.01 < P < 0.05). There was no significant difference in the distribution of GSTM1 genotypes between Chinese and Caucasian Americans.en_HK
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/lungcanen_HK
dc.relation.ispartofLung Canceren_HK
dc.rightsLung Cancer. Copyright © Elsevier Ireland Ltd.-
dc.subjectgenotypeen_HK
dc.subjectGSTen_HK
dc.subjectL-mycen_HK
dc.subjectlung canceren_HK
dc.subject.meshCarcinoma, Non-Small-Cell Lung - Ethnology - Genetics - Mortalityen_US
dc.subject.meshChina - Epidemiologyen_US
dc.subject.meshDna Probes - Chemistryen_US
dc.subject.meshDna, Neoplasm - Analysisen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenes, Myc - Geneticsen_US
dc.subject.meshGenotypeen_US
dc.subject.meshGlutathione Transferase - Geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshIsoenzymes - Geneticsen_US
dc.subject.meshLung Neoplasms - Ethnology - Genetics - Mortalityen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPolymorphism, Restriction Fragment Lengthen_US
dc.subject.meshQuestionnairesen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshSex Factorsen_US
dc.subject.meshSurvival Rateen_US
dc.subject.meshTumor Markers, Biologicalen_US
dc.titleAnalysis of L-myc and GSTM1 genotypes in Chinese non-small cell lung carcinoma patientsen_HK
dc.typeArticleen_HK
dc.identifier.emailLam, WK: lamwk@hku.hken_HK
dc.identifier.emailWong, MP: mwpik@hkucc.hku.hken_HK
dc.identifier.emailLung, ML: mlilung@hku.hk-
dc.identifier.authorityWong, MP=rp00348en_HK
dc.identifier.authorityLung, ML=rp00300en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0169-5002(95)00598-6en_HK
dc.identifier.pmid8959680-
dc.identifier.scopuseid_2-s2.0-0030297801en_HK
dc.identifier.hkuros21746-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030297801&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume15en_HK
dc.identifier.issue3en_HK
dc.identifier.spage355en_HK
dc.identifier.epage366en_HK
dc.identifier.isiWOS:A1996VW72200006-
dc.publisher.placeIrelanden_HK
dc.identifier.scopusauthoridGe, H=55137880800en_HK
dc.identifier.scopusauthoridLam, WK=7203021937en_HK
dc.identifier.scopusauthoridLee, J=27169550700en_HK
dc.identifier.scopusauthoridWong, MP=7403907887en_HK
dc.identifier.scopusauthoridYew, WW=16940459600en_HK
dc.identifier.scopusauthoridLung, ML=7006411788en_HK
dc.customcontrol.immutablesml 130620-

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