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Article: Chromosomal 11 alterations in non-small-cell lung carcinomas in Hong Kong

TitleChromosomal 11 alterations in non-small-cell lung carcinomas in Hong Kong
Authors
KeywordsChromosome
Genetic alterations
NSCLC
Issue Date1996
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/lungcan
Citation
Lung Cancer, 1996, v. 15 n. 1, p. 51-65 How to Cite?
AbstractWe examined 60 non-small-cell lung cancer (NSCLC) patients for evidence of genetic alterations on chromosome 11 with nine polymorphic markers by Southern blot and microsatellite marker analysis. These analyses detected genetic alterations at both the 11p and 11q arms. At the 11p15 Ha-ras locus, the loss of heterozygosity (LOH) occurred in three out of 11 (27.3%) of the informative cases; at the 11pll-q12 D11S149 locus, the LOH occurred in two out of nine (22.2%) of the informative cases: and at the 11q13 INT-2 locus, the LOH occurred in four out of 18 (22.2%) of the informative cases. Microsatellite markers in the 11q12-q13 region revealed genetic alterations for PYGM in eight out of 54 (14.8%) of the specimens studied and 10 out of 55 (18.2%) of the specimens for the INT-2 marker. The data suggest genetic alterations occur in some of the lung cancer patients in both the 11 p and 11q regions.
Persistent Identifierhttp://hdl.handle.net/10722/148060
ISSN
2015 Impact Factor: 3.767
2015 SCImago Journal Rankings: 1.923
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan, ASKen_HK
dc.contributor.authorLam, WKen_HK
dc.contributor.authorWong, MPen_HK
dc.contributor.authorFu, KHen_HK
dc.contributor.authorLee, Jen_HK
dc.contributor.authorYew, WWen_HK
dc.contributor.authorChiu, SWen_HK
dc.contributor.authorLung, MLen_HK
dc.date.accessioned2012-05-29T06:10:38Z-
dc.date.available2012-05-29T06:10:38Z-
dc.date.issued1996en_HK
dc.identifier.citationLung Cancer, 1996, v. 15 n. 1, p. 51-65en_HK
dc.identifier.issn0169-5002en_HK
dc.identifier.urihttp://hdl.handle.net/10722/148060-
dc.description.abstractWe examined 60 non-small-cell lung cancer (NSCLC) patients for evidence of genetic alterations on chromosome 11 with nine polymorphic markers by Southern blot and microsatellite marker analysis. These analyses detected genetic alterations at both the 11p and 11q arms. At the 11p15 Ha-ras locus, the loss of heterozygosity (LOH) occurred in three out of 11 (27.3%) of the informative cases; at the 11pll-q12 D11S149 locus, the LOH occurred in two out of nine (22.2%) of the informative cases: and at the 11q13 INT-2 locus, the LOH occurred in four out of 18 (22.2%) of the informative cases. Microsatellite markers in the 11q12-q13 region revealed genetic alterations for PYGM in eight out of 54 (14.8%) of the specimens studied and 10 out of 55 (18.2%) of the specimens for the INT-2 marker. The data suggest genetic alterations occur in some of the lung cancer patients in both the 11 p and 11q regions.en_HK
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/lungcanen_HK
dc.relation.ispartofLung Canceren_HK
dc.rightsLung Cancer. Copyright © Elsevier Ireland Ltd.-
dc.subjectChromosomeen_HK
dc.subjectGenetic alterationsen_HK
dc.subjectNSCLCen_HK
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshBlotting, Southernen_US
dc.subject.meshCarcinoma, Non-Small-Cell Lung - Geneticsen_US
dc.subject.meshChromosome Aberrationsen_US
dc.subject.meshChromosomes, Human, Pair 11en_US
dc.subject.meshFemaleen_US
dc.subject.meshHeterozygoteen_US
dc.subject.meshHong Kongen_US
dc.subject.meshHumansen_US
dc.subject.meshLung Neoplasms - Geneticsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshSex Factorsen_US
dc.subject.meshSmoking - Adverse Effectsen_US
dc.titleChromosomal 11 alterations in non-small-cell lung carcinomas in Hong Kongen_HK
dc.typeArticleen_HK
dc.identifier.emailWong, MP:mwpik@hkucc.hku.hken_HK
dc.identifier.emailLung, ML:mlilung@hku.hken_HK
dc.identifier.authorityWong, MP=rp00348en_HK
dc.identifier.authorityLung, ML=rp00300en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0169-5002(96)00570-3en_HK
dc.identifier.pmid8865123-
dc.identifier.scopuseid_2-s2.0-0030220849en_HK
dc.identifier.hkuros20042-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030220849&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume15en_HK
dc.identifier.issue1en_HK
dc.identifier.spage51en_HK
dc.identifier.epage65en_HK
dc.identifier.isiWOS:A1996VD11200005-
dc.publisher.placeIrelanden_HK
dc.identifier.scopusauthoridChan, ASK=37019610200en_HK
dc.identifier.scopusauthoridLam, WK=7203021937en_HK
dc.identifier.scopusauthoridWong, MP=7403907887en_HK
dc.identifier.scopusauthoridFu, KH=7202283800en_HK
dc.identifier.scopusauthoridLee, J=27169550700en_HK
dc.identifier.scopusauthoridYew, WW=16940459600en_HK
dc.identifier.scopusauthoridChiu, SW=12788356600en_HK
dc.identifier.scopusauthoridLung, ML=7006411788en_HK

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