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Article: Absence of Epstein-Barr virus in penile carcinoma: A study of 42 cases using in situ hybridization

TitleAbsence of Epstein-Barr virus in penile carcinoma: A study of 42 cases using in situ hybridization
Authors
Issue Date1995
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741
Citation
Cancer, 1995, v. 76 n. 4, p. 658-660 How to Cite?
AbstractBackground. The relationship between Epstein-Barr virus (EBV) and carcinomas of the lower female genital tract has been the focus of some studies in recent years. However, the association between EBV and penile carcinoma never has been investigated. The aim of this study was to identify the possible role of EBV in penile carcinoma of Chinese patients. Methods. Formalin fixed, paraffin embedded tissue of 42 cases of penile carcinoma (including 7 verrucous, 14 well differentiated, 15 moderately differentiated, and 6 poorly differentiated squamous cell carcinomas), 6 penile warts, and 9 normal penile samples were analyzed for EBV using in situ hybridization for EBV-encoded RNA (EBER). Results. Epstein-Barr virus was only found in a few lymphocytes adjacent to the tumor epithelium in 12% (5 cases) of penile carcinoma. Conversely, the tumor cells, penile warts, and normal penile tissue were negative for EBV. Conclusions. The results suggest that EBV does not play a major role in the etiology of penile carcinoma.
Persistent Identifierhttp://hdl.handle.net/10722/148051
ISSN
2015 Impact Factor: 5.649
2015 SCImago Journal Rankings: 3.188
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLam, KYen_US
dc.contributor.authorChan, ACLen_US
dc.contributor.authorChan, KWen_US
dc.contributor.authorLeung, MLen_US
dc.contributor.authorSrivastava, Gen_US
dc.date.accessioned2012-05-29T06:10:35Z-
dc.date.available2012-05-29T06:10:35Z-
dc.date.issued1995en_US
dc.identifier.citationCancer, 1995, v. 76 n. 4, p. 658-660en_US
dc.identifier.issn0008-543Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/148051-
dc.description.abstractBackground. The relationship between Epstein-Barr virus (EBV) and carcinomas of the lower female genital tract has been the focus of some studies in recent years. However, the association between EBV and penile carcinoma never has been investigated. The aim of this study was to identify the possible role of EBV in penile carcinoma of Chinese patients. Methods. Formalin fixed, paraffin embedded tissue of 42 cases of penile carcinoma (including 7 verrucous, 14 well differentiated, 15 moderately differentiated, and 6 poorly differentiated squamous cell carcinomas), 6 penile warts, and 9 normal penile samples were analyzed for EBV using in situ hybridization for EBV-encoded RNA (EBER). Results. Epstein-Barr virus was only found in a few lymphocytes adjacent to the tumor epithelium in 12% (5 cases) of penile carcinoma. Conversely, the tumor cells, penile warts, and normal penile tissue were negative for EBV. Conclusions. The results suggest that EBV does not play a major role in the etiology of penile carcinoma.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741en_US
dc.relation.ispartofCanceren_US
dc.rightsCancer. Copyright © John Wiley & Sons, Inc.-
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshCarcinoma, Squamous Cell - Microbiologyen_US
dc.subject.meshHerpesviridae Infections - Complicationsen_US
dc.subject.meshHerpesvirus 4, Humanen_US
dc.subject.meshHong Kongen_US
dc.subject.meshHumansen_US
dc.subject.meshIn Situ Hybridizationen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPenile Neoplasms - Microbiologyen_US
dc.subject.meshRna, Viral - Analysisen_US
dc.subject.meshTumor Virus Infections - Complicationsen_US
dc.titleAbsence of Epstein-Barr virus in penile carcinoma: A study of 42 cases using in situ hybridizationen_US
dc.typeArticleen_US
dc.identifier.emailChan, KW:hrmtckw@hku.hken_US
dc.identifier.emailSrivastava, G:gopesh@pathology.hku.hken_US
dc.identifier.authorityChan, KW=rp00330en_US
dc.identifier.authoritySrivastava, G=rp00365en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1002/1097-0142(19950815)76:4<658::AID-CNCR2820760418>3.0.CO;2-Ben_US
dc.identifier.pmid8625161-
dc.identifier.scopuseid_2-s2.0-0029162338en_US
dc.identifier.hkuros14097-
dc.identifier.volume76en_US
dc.identifier.issue4en_US
dc.identifier.spage658en_US
dc.identifier.epage660en_US
dc.identifier.isiWOS:A1995RN41800017-
dc.publisher.placeUnited Statesen_US

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