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Article: Trisomy 12 in chronic lymphocytic leukemia: An interphase cytogenetic study by fluorescence in situ hybridization
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TitleTrisomy 12 in chronic lymphocytic leukemia: An interphase cytogenetic study by fluorescence in situ hybridization
 
AuthorsKwong, YL1
Pang, J1
Ching, LM1
Liu, HW1
Liang, RHS1
Chan, LC1
 
Issue Date1994
 
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergene
 
CitationCancer Genetics And Cytogenetics, 1994, v. 72 n. 2, p. 83-85 [How to Cite?]
DOI: http://dx.doi.org/10.1016/0165-4608(94)90119-8
 
AbstractB-cell chronic lymphocytic leukemia (CLL) is a rare disorder in the Chinese population. We evaluated the use of fluorescence in situ hybridization (FISH) with a chromosome 12-specific probe in the detection of trisomy 12 in interphase cells of 19 Chinese CLL patients. FISH successfully detected trisomy 12 in two cases, one of which had normal conventional cytogenetic findings, giving an incidence of 10%. The low incidence of trisomy 12 in our CLL patients may also reflect a biologic difference of this rare disorder in our population, compared to that of the West.
 
ISSN0165-4608
2012 Impact Factor: 1.929
 
DOIhttp://dx.doi.org/10.1016/0165-4608(94)90119-8
 
ISI Accession Number IDWOS:A1994NN05800001
 
DC FieldValue
dc.contributor.authorKwong, YL
 
dc.contributor.authorPang, J
 
dc.contributor.authorChing, LM
 
dc.contributor.authorLiu, HW
 
dc.contributor.authorLiang, RHS
 
dc.contributor.authorChan, LC
 
dc.date.accessioned2012-05-29T06:10:28Z
 
dc.date.available2012-05-29T06:10:28Z
 
dc.date.issued1994
 
dc.description.abstractB-cell chronic lymphocytic leukemia (CLL) is a rare disorder in the Chinese population. We evaluated the use of fluorescence in situ hybridization (FISH) with a chromosome 12-specific probe in the detection of trisomy 12 in interphase cells of 19 Chinese CLL patients. FISH successfully detected trisomy 12 in two cases, one of which had normal conventional cytogenetic findings, giving an incidence of 10%. The low incidence of trisomy 12 in our CLL patients may also reflect a biologic difference of this rare disorder in our population, compared to that of the West.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationCancer Genetics And Cytogenetics, 1994, v. 72 n. 2, p. 83-85 [How to Cite?]
DOI: http://dx.doi.org/10.1016/0165-4608(94)90119-8
 
dc.identifier.doihttp://dx.doi.org/10.1016/0165-4608(94)90119-8
 
dc.identifier.epage85
 
dc.identifier.isiWOS:A1994NN05800001
 
dc.identifier.issn0165-4608
2012 Impact Factor: 1.929
 
dc.identifier.issue2
 
dc.identifier.pmid8143280
 
dc.identifier.scopuseid_2-s2.0-0028359657
 
dc.identifier.spage83
 
dc.identifier.urihttp://hdl.handle.net/10722/148028
 
dc.identifier.volume72
 
dc.languageeng
 
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergene
 
dc.publisher.placeUnited States
 
dc.relation.ispartofCancer Genetics and Cytogenetics
 
dc.subject.meshAdult
 
dc.subject.meshAged
 
dc.subject.meshChromosomes, Human, Pair 12
 
dc.subject.meshFemale
 
dc.subject.meshHumans
 
dc.subject.meshIn Situ Hybridization, Fluorescence
 
dc.subject.meshInterphase - Genetics
 
dc.subject.meshLeukemia, Lymphocytic, Chronic, B-Cell - Genetics
 
dc.subject.meshMale
 
dc.subject.meshMiddle Aged
 
dc.subject.meshTrisomy
 
dc.titleTrisomy 12 in chronic lymphocytic leukemia: An interphase cytogenetic study by fluorescence in situ hybridization
 
dc.typeArticle
 
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<item><contributor.author>Kwong, YL</contributor.author>
<contributor.author>Pang, J</contributor.author>
<contributor.author>Ching, LM</contributor.author>
<contributor.author>Liu, HW</contributor.author>
<contributor.author>Liang, RHS</contributor.author>
<contributor.author>Chan, LC</contributor.author>
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<description.abstract>B-cell chronic lymphocytic leukemia (CLL) is a rare disorder in the Chinese population. We evaluated the use of fluorescence in situ hybridization (FISH) with a chromosome 12-specific probe in the detection of trisomy 12 in interphase cells of 19 Chinese CLL patients. FISH successfully detected trisomy 12 in two cases, one of which had normal conventional cytogenetic findings, giving an incidence of 10%. The low incidence of trisomy 12 in our CLL patients may also reflect a biologic difference of this rare disorder in our population, compared to that of the West.</description.abstract>
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Author Affiliations
  1. The University of Hong Kong