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Article: Trisomy 12 in chronic lymphocytic leukemia: An interphase cytogenetic study by fluorescence in situ hybridization

TitleTrisomy 12 in chronic lymphocytic leukemia: An interphase cytogenetic study by fluorescence in situ hybridization
Authors
Issue Date1994
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergene
Citation
Cancer Genetics And Cytogenetics, 1994, v. 72 n. 2, p. 83-85 How to Cite?
AbstractB-cell chronic lymphocytic leukemia (CLL) is a rare disorder in the Chinese population. We evaluated the use of fluorescence in situ hybridization (FISH) with a chromosome 12-specific probe in the detection of trisomy 12 in interphase cells of 19 Chinese CLL patients. FISH successfully detected trisomy 12 in two cases, one of which had normal conventional cytogenetic findings, giving an incidence of 10%. The low incidence of trisomy 12 in our CLL patients may also reflect a biologic difference of this rare disorder in our population, compared to that of the West.
Persistent Identifierhttp://hdl.handle.net/10722/148028
ISSN
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKwong, YLen_HK
dc.contributor.authorPang, Jen_HK
dc.contributor.authorChing, LMen_HK
dc.contributor.authorLiu, HWen_HK
dc.contributor.authorLiang, RHSen_HK
dc.contributor.authorChan, LCen_HK
dc.date.accessioned2012-05-29T06:10:28Z-
dc.date.available2012-05-29T06:10:28Z-
dc.date.issued1994en_HK
dc.identifier.citationCancer Genetics And Cytogenetics, 1994, v. 72 n. 2, p. 83-85en_HK
dc.identifier.issn0165-4608en_HK
dc.identifier.urihttp://hdl.handle.net/10722/148028-
dc.description.abstractB-cell chronic lymphocytic leukemia (CLL) is a rare disorder in the Chinese population. We evaluated the use of fluorescence in situ hybridization (FISH) with a chromosome 12-specific probe in the detection of trisomy 12 in interphase cells of 19 Chinese CLL patients. FISH successfully detected trisomy 12 in two cases, one of which had normal conventional cytogenetic findings, giving an incidence of 10%. The low incidence of trisomy 12 in our CLL patients may also reflect a biologic difference of this rare disorder in our population, compared to that of the West.en_HK
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergeneen_HK
dc.relation.ispartofCancer Genetics and Cytogeneticsen_HK
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshChromosomes, Human, Pair 12en_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshIn Situ Hybridization, Fluorescenceen_US
dc.subject.meshInterphase - Geneticsen_US
dc.subject.meshLeukemia, Lymphocytic, Chronic, B-Cell - Geneticsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshTrisomyen_US
dc.titleTrisomy 12 in chronic lymphocytic leukemia: An interphase cytogenetic study by fluorescence in situ hybridizationen_HK
dc.typeArticleen_HK
dc.identifier.emailKwong, YL:ylkwong@hku.hken_HK
dc.identifier.emailLiang, RHS:rliang@hku.hken_HK
dc.identifier.emailChan, LC:chanlc@hkucc.hku.hken_HK
dc.identifier.authorityKwong, YL=rp00358en_HK
dc.identifier.authorityLiang, RHS=rp00345en_HK
dc.identifier.authorityChan, LC=rp00373en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0165-4608(94)90119-8en_HK
dc.identifier.pmid8143280en_HK
dc.identifier.scopuseid_2-s2.0-0028359657en_HK
dc.identifier.volume72en_HK
dc.identifier.issue2en_HK
dc.identifier.spage83en_HK
dc.identifier.epage85en_HK
dc.identifier.isiWOS:A1994NN05800001-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridKwong, YL=7102818954en_HK
dc.identifier.scopusauthoridPang, J=7201733978en_HK
dc.identifier.scopusauthoridChing, LM=24293081200en_HK
dc.identifier.scopusauthoridLiu, HW=7409752648en_HK
dc.identifier.scopusauthoridLiang, RHS=26643224900en_HK
dc.identifier.scopusauthoridChan, LC=7403540707en_HK

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