Article: Trisomy 12 in chronic lymphocytic leukemia: An interphase cytogenetic study by fluorescence in situ hybridization

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TitleTrisomy 12 in chronic lymphocytic leukemia: An interphase cytogenetic study by fluorescence in situ hybridization
AuthorsKwong, YL1
Pang, J1
Ching, LM1
Liu, HW1
Liang, RHS1
Chan, LC1
Issue Date1994
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergene
CitationCancer Genetics And Cytogenetics, 1994, v. 72 n. 2, p. 83-85 [How to Cite?]
DOI: http://dx.doi.org/10.1016/0165-4608(94)90119-8
AbstractB-cell chronic lymphocytic leukemia (CLL) is a rare disorder in the Chinese population. We evaluated the use of fluorescence in situ hybridization (FISH) with a chromosome 12-specific probe in the detection of trisomy 12 in interphase cells of 19 Chinese CLL patients. FISH successfully detected trisomy 12 in two cases, one of which had normal conventional cytogenetic findings, giving an incidence of 10%. The low incidence of trisomy 12 in our CLL patients may also reflect a biologic difference of this rare disorder in our population, compared to that of the West.
ISSN0165-4608
2011 Impact Factor: 1.389
2011 SCImago Journal Rankings: 0.162
DOIhttp://dx.doi.org/10.1016/0165-4608(94)90119-8
ISI Accession Number IDWOS:A1994NN05800001
DC Field
Value
dc.contributor.authorKwong, YL
dc.contributor.authorPang, J
dc.contributor.authorChing, LM
dc.contributor.authorLiu, HW
dc.contributor.authorLiang, RHS
dc.contributor.authorChan, LC
dc.date.accessioned2012-05-29T06:10:28Z
dc.date.available2012-05-29T06:10:28Z
dc.date.issued1994
dc.description.abstractB-cell chronic lymphocytic leukemia (CLL) is a rare disorder in the Chinese population. We evaluated the use of fluorescence in situ hybridization (FISH) with a chromosome 12-specific probe in the detection of trisomy 12 in interphase cells of 19 Chinese CLL patients. FISH successfully detected trisomy 12 in two cases, one of which had normal conventional cytogenetic findings, giving an incidence of 10%. The low incidence of trisomy 12 in our CLL patients may also reflect a biologic difference of this rare disorder in our population, compared to that of the West.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationCancer Genetics And Cytogenetics, 1994, v. 72 n. 2, p. 83-85 [How to Cite?]
DOI: http://dx.doi.org/10.1016/0165-4608(94)90119-8
dc.identifier.doihttp://dx.doi.org/10.1016/0165-4608(94)90119-8
dc.identifier.epage85
dc.identifier.isiWOS:A1994NN05800001
dc.identifier.issn0165-4608
2011 Impact Factor: 1.389
2011 SCImago Journal Rankings: 0.162
dc.identifier.issue2
dc.identifier.pmid8143280
dc.identifier.scopuseid_2-s2.0-0028359657
dc.identifier.spage83
dc.identifier.urihttp://hdl.handle.net/10722/148028
dc.identifier.volume72
dc.languageeng
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergene
dc.publisher.placeUnited States
dc.relation.ispartofCancer Genetics and Cytogenetics
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshChromosomes, Human, Pair 12
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshIn Situ Hybridization, Fluorescence
dc.subject.meshInterphase - Genetics
dc.subject.meshLeukemia, Lymphocytic, Chronic, B-Cell - Genetics
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshTrisomy
dc.titleTrisomy 12 in chronic lymphocytic leukemia: An interphase cytogenetic study by fluorescence in situ hybridization
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong