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Article: Cytogenetic triclonality in acute myeloid leukemia: A morphologic, immunologic and in situ hybridization study

TitleCytogenetic triclonality in acute myeloid leukemia: A morphologic, immunologic and in situ hybridization study
Authors
Issue Date1994
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergene
Citation
Cancer Genetics And Cytogenetics, 1994, v. 72 n. 2, p. 86-91 How to Cite?
AbstractCytogenetically unrelated clones are uncommon in hematologic malignancies. We report a case of acute myeloid leukemia, which consisted morphologically of two populations of small and large blasts demonstrating immunophenotypic heterogeneity. Cytogenetic analysis showed 3 karyotypically abnormal clones: 47,XY, +14/45,XY,dic(5;17)(q11;p11),14dmin, and a near-tetraploid clone. In situ hybridization showed that the near-tetraploid clone corresponded to the large blasts, and the near-diploid clones the small blasts, therefore demonstrating a direct relationship between cell size and DNA content. The diverse morphologic, immunologic and cytogenetic heterogeneity observed in our case suggested hematopoietic oligoclonality.
Persistent Identifierhttp://hdl.handle.net/10722/148022
ISSN
2012 Impact Factor: 1.929
2013 SCImago Journal Rankings: 0.872
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKwong, YLen_HK
dc.contributor.authorLam, CKen_HK
dc.contributor.authorChan, AYYen_HK
dc.contributor.authorLie, AKWen_HK
dc.contributor.authorChan, LCen_HK
dc.date.accessioned2012-05-29T06:10:26Z-
dc.date.available2012-05-29T06:10:26Z-
dc.date.issued1994en_HK
dc.identifier.citationCancer Genetics And Cytogenetics, 1994, v. 72 n. 2, p. 86-91en_HK
dc.identifier.issn0165-4608en_HK
dc.identifier.urihttp://hdl.handle.net/10722/148022-
dc.description.abstractCytogenetically unrelated clones are uncommon in hematologic malignancies. We report a case of acute myeloid leukemia, which consisted morphologically of two populations of small and large blasts demonstrating immunophenotypic heterogeneity. Cytogenetic analysis showed 3 karyotypically abnormal clones: 47,XY, +14/45,XY,dic(5;17)(q11;p11),14dmin, and a near-tetraploid clone. In situ hybridization showed that the near-tetraploid clone corresponded to the large blasts, and the near-diploid clones the small blasts, therefore demonstrating a direct relationship between cell size and DNA content. The diverse morphologic, immunologic and cytogenetic heterogeneity observed in our case suggested hematopoietic oligoclonality.en_HK
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergeneen_HK
dc.relation.ispartofCancer Genetics and Cytogeneticsen_HK
dc.rightsCancer Genetics and Cytogenetics. Copyright © Elsevier Inc.-
dc.subject.meshAgeden_US
dc.subject.meshChromosome Aberrationsen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunophenotypingen_US
dc.subject.meshIn Situ Hybridizationen_US
dc.subject.meshLeukemia, Myeloid, Acute - Genetics - Immunology - Pathologyen_US
dc.subject.meshMaleen_US
dc.titleCytogenetic triclonality in acute myeloid leukemia: A morphologic, immunologic and in situ hybridization studyen_HK
dc.typeArticleen_HK
dc.identifier.emailKwong, YL:ylkwong@hku.hken_HK
dc.identifier.emailChan, LC:chanlc@hkucc.hku.hken_HK
dc.identifier.authorityKwong, YL=rp00358en_HK
dc.identifier.authorityChan, LC=rp00373en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0165-4608(94)90120-1en_HK
dc.identifier.pmid8143281-
dc.identifier.scopuseid_2-s2.0-0028303427en_HK
dc.identifier.hkuros6091-
dc.identifier.volume72en_HK
dc.identifier.issue2en_HK
dc.identifier.spage86en_HK
dc.identifier.epage91en_HK
dc.identifier.isiWOS:A1994NN05800002-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridKwong, YL=7102818954en_HK
dc.identifier.scopusauthoridLam, CK=7402990915en_HK
dc.identifier.scopusauthoridChan, AYY=7403168182en_HK
dc.identifier.scopusauthoridLie, AKW=7004510870en_HK
dc.identifier.scopusauthoridChan, LC=7403540707en_HK

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