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Article: Childhood acute lymphoblastic leukaemia presenting with relapsing hypoplastic anaemia: Progression of the same abnormal clone

TitleChildhood acute lymphoblastic leukaemia presenting with relapsing hypoplastic anaemia: Progression of the same abnormal clone
Authors
Issue Date1993
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJH
Citation
British Journal Of Haematology, 1993, v. 83 n. 2, p. 340-342 How to Cite?
AbstractA 13-year-old girl presented with two spontaneously reversible episodes of marrow hypoplasia. She subsequently developed acute lymphoblastic leukaemia (ALL) 8 months later. Southern analysis showed identical clonal immunoglobulin heavy chain gene rearrangement bands in the leukaemic cells as well as the marrow cells obtained at the two hypoplastic episodes. Hypoxanthine phosphoribosyl transferase polymorphism studies showed that the ALL blast cells, bone marrow and peripheral blood cells during the two hypoplastic episodes all exhibited clonal haematopoiesis with the same X-chromosome inactivated. This case provides strong evidence that aplastic anaemia and ALL may represent evolution of the same abnormal clone.
Persistent Identifierhttp://hdl.handle.net/10722/147978
ISSN
2015 Impact Factor: 5.401
2015 SCImago Journal Rankings: 2.313
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLiang, Ren_HK
dc.contributor.authorCheng, Gen_HK
dc.contributor.authorWat, MSen_HK
dc.contributor.authorHa, SYen_HK
dc.contributor.authorChan, LCen_HK
dc.date.accessioned2012-05-29T06:10:12Z-
dc.date.available2012-05-29T06:10:12Z-
dc.date.issued1993en_HK
dc.identifier.citationBritish Journal Of Haematology, 1993, v. 83 n. 2, p. 340-342en_HK
dc.identifier.issn0007-1048en_HK
dc.identifier.urihttp://hdl.handle.net/10722/147978-
dc.description.abstractA 13-year-old girl presented with two spontaneously reversible episodes of marrow hypoplasia. She subsequently developed acute lymphoblastic leukaemia (ALL) 8 months later. Southern analysis showed identical clonal immunoglobulin heavy chain gene rearrangement bands in the leukaemic cells as well as the marrow cells obtained at the two hypoplastic episodes. Hypoxanthine phosphoribosyl transferase polymorphism studies showed that the ALL blast cells, bone marrow and peripheral blood cells during the two hypoplastic episodes all exhibited clonal haematopoiesis with the same X-chromosome inactivated. This case provides strong evidence that aplastic anaemia and ALL may represent evolution of the same abnormal clone.en_HK
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJHen_HK
dc.relation.ispartofBritish Journal of Haematologyen_HK
dc.subject.meshAdolescenten_US
dc.subject.meshAnemia, Aplastic - Geneticsen_US
dc.subject.meshBlotting, Southernen_US
dc.subject.meshDna, Neoplasm - Analysisen_US
dc.subject.meshDosage Compensation, Geneticen_US
dc.subject.meshFemaleen_US
dc.subject.meshGene Rearrangementen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunoglobulin Heavy Chains - Geneticsen_US
dc.subject.meshNeoplastic Stem Cells - Chemistryen_US
dc.subject.meshPolymorphism, Geneticen_US
dc.subject.meshPrecursor Cell Lymphoblastic Leukemia-Lymphoma - Geneticsen_US
dc.titleChildhood acute lymphoblastic leukaemia presenting with relapsing hypoplastic anaemia: Progression of the same abnormal cloneen_HK
dc.typeArticleen_HK
dc.identifier.emailLiang, R:rliang@hku.hken_HK
dc.identifier.emailChan, LC:chanlc@hkucc.hku.hken_HK
dc.identifier.authorityLiang, R=rp00345en_HK
dc.identifier.authorityChan, LC=rp00373en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid8457483-
dc.identifier.scopuseid_2-s2.0-0027450676en_HK
dc.identifier.volume83en_HK
dc.identifier.issue2en_HK
dc.identifier.spage340en_HK
dc.identifier.epage342en_HK
dc.identifier.isiWOS:A1993KL51500024-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLiang, R=26643224900en_HK
dc.identifier.scopusauthoridCheng, G=35313354500en_HK
dc.identifier.scopusauthoridWat, MS=6603247639en_HK
dc.identifier.scopusauthoridHa, SY=7202501115en_HK
dc.identifier.scopusauthoridChan, LC=7403540707en_HK

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