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Article: Congenital infection by human cytomegalovirus with a 65 bp deletion in the morphological transforming region II

TitleCongenital infection by human cytomegalovirus with a 65 bp deletion in the morphological transforming region II
Authors
Issue Date1993
PublisherSpringer Wien. The Journal's web site is located at http://www.springer.com/springerwiennewyork/medicine/journal/705
Citation
Archives Of Virology, 1993, v. 129 n. 1-4, p. 295-299 How to Cite?
AbstractHuman cytomegalovirus (HCMV) infection is an important cause of neonatal death. Using primers derived from sequences within the morphological transforming region II (mtrII), HCMV DNA was amplified by polymerase chain reaction (PCR) from fixed tissues of infants who had died of congenital HCMV infection. In one neonate, HCMV DNA with reduction in the expected size was detected in the liver, spleen, kidney, adrenal, und thyroid tissues by gel electrophoresis. Nucleotide sequencing of the PCR product revealed a 65bp frame-shift deletion within the 79 amino acid open reading frame (ORF) of the mtrII. Based upon this observation, it is likely that viral genomic rearrangement involving the mtrII may occur in some cases of congenital HCMV infection. © 1993 Springer-Verlag.
Persistent Identifierhttp://hdl.handle.net/10722/147966
ISSN
2015 Impact Factor: 2.255
2015 SCImago Journal Rankings: 1.086
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLo, SKFen_HK
dc.contributor.authorIp, KWYen_HK
dc.contributor.authorChan, PKSen_HK
dc.contributor.authorNicholls, JMen_HK
dc.contributor.authorHeath, RBen_HK
dc.contributor.authorShiu, SYWen_HK
dc.date.accessioned2012-05-29T06:10:08Z-
dc.date.available2012-05-29T06:10:08Z-
dc.date.issued1993en_HK
dc.identifier.citationArchives Of Virology, 1993, v. 129 n. 1-4, p. 295-299en_HK
dc.identifier.issn0304-8608en_HK
dc.identifier.urihttp://hdl.handle.net/10722/147966-
dc.description.abstractHuman cytomegalovirus (HCMV) infection is an important cause of neonatal death. Using primers derived from sequences within the morphological transforming region II (mtrII), HCMV DNA was amplified by polymerase chain reaction (PCR) from fixed tissues of infants who had died of congenital HCMV infection. In one neonate, HCMV DNA with reduction in the expected size was detected in the liver, spleen, kidney, adrenal, und thyroid tissues by gel electrophoresis. Nucleotide sequencing of the PCR product revealed a 65bp frame-shift deletion within the 79 amino acid open reading frame (ORF) of the mtrII. Based upon this observation, it is likely that viral genomic rearrangement involving the mtrII may occur in some cases of congenital HCMV infection. © 1993 Springer-Verlag.en_HK
dc.languageengen_US
dc.publisherSpringer Wien. The Journal's web site is located at http://www.springer.com/springerwiennewyork/medicine/journal/705en_HK
dc.relation.ispartofArchives of Virologyen_HK
dc.titleCongenital infection by human cytomegalovirus with a 65 bp deletion in the morphological transforming region IIen_HK
dc.typeArticleen_HK
dc.identifier.emailNicholls, JM: nicholls@pathology.hku.hken_HK
dc.identifier.emailShiu, SYW: sywshiu@hkucc.hku.hken_HK
dc.identifier.authorityNicholls, JM=rp00364en_HK
dc.identifier.authorityShiu, SYW=rp00384en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/BF01316904en_HK
dc.identifier.pmid8385917-
dc.identifier.scopuseid_2-s2.0-0027350202en_HK
dc.identifier.volume129en_HK
dc.identifier.issue1-4en_HK
dc.identifier.spage295en_HK
dc.identifier.epage299en_HK
dc.identifier.isiWOS:A1993KT98600025-
dc.publisher.placeAustriaen_HK
dc.identifier.scopusauthoridLo, SKF=7401542391en_HK
dc.identifier.scopusauthoridIp, KWY=7006315589en_HK
dc.identifier.scopusauthoridChan, PKS=7403497792en_HK
dc.identifier.scopusauthoridNicholls, JM=7201463077en_HK
dc.identifier.scopusauthoridHeath, RB=7202694890en_HK
dc.identifier.scopusauthoridShiu, SYW=7005550655en_HK

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