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Article: In utero rearrangements in the trithorax-related oncogene in infant leukaemias

TitleIn utero rearrangements in the trithorax-related oncogene in infant leukaemias
Authors
Issue Date1993
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/nature
Citation
Nature, 1993, v. 363 n. 6427, p. 358-360 How to Cite?
AbstractThe majority (~ 75%) of infant acute leukaemias have a reciprocal translocation between chromosome 11q23 and one of several partner chromosomes. The gene at 11q23 (named MLL, ALT-1, HRX or HTRX-1) has been cloned and shares homology with the Drosophilaila developmental genetrithorax. Rearrangements of this gene (called HRX here) occur in introns and cluster in a region of ~ 10 kb; individual patients have difierent breakpoints. Here we describe three pairs of infant twins with concordant leukaemia who each share unique (clonal) but non-constitutive HRX rearrangements in their leukaemic cells, providing evidence that the leukaemogenic event originates in utero and unequivocal support for the intra-placental 'metastasis' hypothesis for leukaemia concordance in twins.
Persistent Identifierhttp://hdl.handle.net/10722/147960
ISSN
2015 Impact Factor: 38.138
2015 SCImago Journal Rankings: 21.936
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorFord, AMen_US
dc.contributor.authorRidge, SAen_US
dc.contributor.authorCabrera, MEen_US
dc.contributor.authorMahmoud, Hen_US
dc.contributor.authorSteel, CMen_US
dc.contributor.authorChan, LCen_US
dc.contributor.authorGreaves, Men_US
dc.date.accessioned2012-05-29T06:10:06Z-
dc.date.available2012-05-29T06:10:06Z-
dc.date.issued1993en_US
dc.identifier.citationNature, 1993, v. 363 n. 6427, p. 358-360en_US
dc.identifier.issn0028-0836en_US
dc.identifier.urihttp://hdl.handle.net/10722/147960-
dc.description.abstractThe majority (~ 75%) of infant acute leukaemias have a reciprocal translocation between chromosome 11q23 and one of several partner chromosomes. The gene at 11q23 (named MLL, ALT-1, HRX or HTRX-1) has been cloned and shares homology with the Drosophilaila developmental genetrithorax. Rearrangements of this gene (called HRX here) occur in introns and cluster in a region of ~ 10 kb; individual patients have difierent breakpoints. Here we describe three pairs of infant twins with concordant leukaemia who each share unique (clonal) but non-constitutive HRX rearrangements in their leukaemic cells, providing evidence that the leukaemogenic event originates in utero and unequivocal support for the intra-placental 'metastasis' hypothesis for leukaemia concordance in twins.en_US
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/natureen_US
dc.relation.ispartofNatureen_US
dc.subject.meshChromosomes, Human, Pair 11en_US
dc.subject.meshClone Cellsen_US
dc.subject.meshDna-Binding Proteins - Geneticsen_US
dc.subject.meshDiseases In Twins - Geneticsen_US
dc.subject.meshDosage Compensation, Geneticen_US
dc.subject.meshFemaleen_US
dc.subject.meshGene Rearrangementen_US
dc.subject.meshGene Rearrangement, B-Lymphocyteen_US
dc.subject.meshGene Rearrangement, T-Lymphocyteen_US
dc.subject.meshHumansen_US
dc.subject.meshInfanten_US
dc.subject.meshMaleen_US
dc.subject.meshMyeloid-Lymphoid Leukemia Proteinen_US
dc.subject.meshNeoplasm Metastasisen_US
dc.subject.meshOncogenesen_US
dc.subject.meshPlacentaen_US
dc.subject.meshPrecursor Cell Lymphoblastic Leukemia-Lymphoma - Embryology - Geneticsen_US
dc.subject.meshPregnancyen_US
dc.subject.meshProto-Oncogenesen_US
dc.subject.meshTranscription Factorsen_US
dc.subject.meshTwins, Monozygoticen_US
dc.titleIn utero rearrangements in the trithorax-related oncogene in infant leukaemiasen_US
dc.typeArticleen_US
dc.identifier.emailChan, LC:chanlc@hkucc.hku.hken_US
dc.identifier.authorityChan, LC=rp00373en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1038/363358a0en_US
dc.identifier.pmid8497319-
dc.identifier.scopuseid_2-s2.0-0027276927en_US
dc.identifier.volume363en_US
dc.identifier.issue6427en_US
dc.identifier.spage358en_US
dc.identifier.epage360en_US
dc.identifier.isiWOS:A1993LD91700056-
dc.publisher.placeUnited Kingdomen_US

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