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Article: Clonal Epstein-Barr virus in lymphoepithelioma-like carcinoma of the lung

TitleClonal Epstein-Barr virus in lymphoepithelioma-like carcinoma of the lung
Authors
KeywordsEpstein-Barr virus
Lung carcinoma
Lymphoepithelioma-like carcinoma
Issue Date1993
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.ajsp.com
Citation
American Journal Of Surgical Pathology, 1993, v. 17 n. 7, p. 678-682 How to Cite?
AbstractLymphoepithelioma of the nasopharynx is an undifferentiated carcinoma with a prominent lymphoid infiltrate. A consistent association with Epstein-Barr virus (EBV) has been demonstrated over the years by a variety of methods. More recently, undifferentiated carcinomas with a similar morphology have been described in other anatomical locations, often of foregut origin. However, for lymphoepithelioma-like carcinoma, the association with EBV has been more tenuous, especially in Western countries. Interestingly, these tumors have shown a geographic distribution similar to nasopharyngeal lymphoepithelioma, with relatively high frequency of EBV positive cases in Asian patients. We report five cases of lymphoepithelioma-like carcinoma arising in the lung. In situ hybridization revealed the presence of EBV in all cases with localization to the epithelial cells only. Southern-blot analysis from two cases revealed the presence of clonal episomal EBV in the tumor tissue. These findings further support the hypothesis that EBV is also associated with lymphoepithelioma-like lung carcinomas and suggest that EBV infection has preceded the clonal expansion of the tumor.
Persistent Identifierhttp://hdl.handle.net/10722/147947
ISSN
2015 Impact Factor: 4.951
2015 SCImago Journal Rankings: 2.393
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorPittaluga, Sen_HK
dc.contributor.authorWong, MPen_HK
dc.contributor.authorChung, LPen_HK
dc.contributor.authorLoke, SLen_HK
dc.date.accessioned2012-05-29T06:10:03Z-
dc.date.available2012-05-29T06:10:03Z-
dc.date.issued1993en_HK
dc.identifier.citationAmerican Journal Of Surgical Pathology, 1993, v. 17 n. 7, p. 678-682en_HK
dc.identifier.issn0147-5185en_HK
dc.identifier.urihttp://hdl.handle.net/10722/147947-
dc.description.abstractLymphoepithelioma of the nasopharynx is an undifferentiated carcinoma with a prominent lymphoid infiltrate. A consistent association with Epstein-Barr virus (EBV) has been demonstrated over the years by a variety of methods. More recently, undifferentiated carcinomas with a similar morphology have been described in other anatomical locations, often of foregut origin. However, for lymphoepithelioma-like carcinoma, the association with EBV has been more tenuous, especially in Western countries. Interestingly, these tumors have shown a geographic distribution similar to nasopharyngeal lymphoepithelioma, with relatively high frequency of EBV positive cases in Asian patients. We report five cases of lymphoepithelioma-like carcinoma arising in the lung. In situ hybridization revealed the presence of EBV in all cases with localization to the epithelial cells only. Southern-blot analysis from two cases revealed the presence of clonal episomal EBV in the tumor tissue. These findings further support the hypothesis that EBV is also associated with lymphoepithelioma-like lung carcinomas and suggest that EBV infection has preceded the clonal expansion of the tumor.en_HK
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.ajsp.comen_HK
dc.relation.ispartofAmerican Journal of Surgical Pathologyen_HK
dc.subjectEpstein-Barr virusen_HK
dc.subjectLung carcinomaen_HK
dc.subjectLymphoepithelioma-like carcinomaen_HK
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshBlotting, Southernen_US
dc.subject.meshCarcinoma - Genetics - Microbiology - Pathologyen_US
dc.subject.meshCarcinoma, Squamous Cell - Pathologyen_US
dc.subject.meshDna, Viral - Analysisen_US
dc.subject.meshGenome, Viralen_US
dc.subject.meshHerpesvirus 4, Human - Genetics - Isolation & Purificationen_US
dc.subject.meshHumansen_US
dc.subject.meshIn Situ Hybridizationen_US
dc.subject.meshLung Neoplasms - Genetics - Microbiology - Pathologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.titleClonal Epstein-Barr virus in lymphoepithelioma-like carcinoma of the lungen_HK
dc.typeArticleen_HK
dc.identifier.emailWong, MP: mwpik@hkucc.hku.hken_HK
dc.identifier.emailChung, LP: lpchung@hkucc.hku.hken_HK
dc.identifier.authorityWong, MP=rp00348en_HK
dc.identifier.authorityChung, LP=rp00249en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid8391220-
dc.identifier.scopuseid_2-s2.0-0027158689en_HK
dc.identifier.volume17en_HK
dc.identifier.issue7en_HK
dc.identifier.spage678en_HK
dc.identifier.epage682en_HK
dc.identifier.isiWOS:A1993LJ01100004-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridPittaluga, S=7006897513en_HK
dc.identifier.scopusauthoridWong, MP=7403907887en_HK
dc.identifier.scopusauthoridChung, LP=24315879100en_HK
dc.identifier.scopusauthoridLoke, SL=7006559512en_HK

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