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- Scopus: eid_2-s2.0-0027008368
- PMID: 1339929
- WOS: WOS:A1992KH16100006
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Article: Use of Technicon H*1 technology in routine thalassaemia screening
Title | Use of Technicon H*1 technology in routine thalassaemia screening |
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Authors | |
Keywords | Anemia, hypochromic Blood cell count Discriminant analysis Thalassemia |
Issue Date | 1992 |
Citation | Medical Laboratory Sciences, 1992, v. 49 n. 4, p. 259-264 How to Cite? |
Abstract | In a retrospective study of 36 cases of alpha-thalassaemia trait, 43 cases of beta-thalassaemia trait and 45 cases of iron deficiency, we have assessed the performance of the Technicon H*1 erythrogram, the hypochromia minus microcytosis (H-M) index, and the discriminant function (DF). The diagnostic accuracy of the erythrogram pattern was 83.3% for alpha-thalassaemia trait and 95.3% for beta-thalassaemia trait. The diagnostic accuracy for the H-M index was 19.4% for alpha-thalassaemia trait, 72.1% for beta-thalassaemia trait and 91.1% for iron deficiency. By comparison, the DF gave a diagnostic accuracy of 75.0% for alpha-thalassaemia trait, 81.4% for beta-thalassaemia trait and 88.9% for iron deficiency when using a locally derived value for the constant (k) = 19.2. Our study shows that the H*1 erythrogram pattern, the H-M index and the DF are useful predictive indicators in routine laboratory screening for thalassaemia. |
Persistent Identifier | http://hdl.handle.net/10722/147942 |
ISSN | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Robertson, EP | en_US |
dc.contributor.author | Pollock, A | en_US |
dc.contributor.author | Yau, KS | en_US |
dc.contributor.author | Chan, LC | en_US |
dc.date.accessioned | 2012-05-29T06:10:01Z | - |
dc.date.available | 2012-05-29T06:10:01Z | - |
dc.date.issued | 1992 | en_US |
dc.identifier.citation | Medical Laboratory Sciences, 1992, v. 49 n. 4, p. 259-264 | en_US |
dc.identifier.issn | 0308-3616 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/147942 | - |
dc.description.abstract | In a retrospective study of 36 cases of alpha-thalassaemia trait, 43 cases of beta-thalassaemia trait and 45 cases of iron deficiency, we have assessed the performance of the Technicon H*1 erythrogram, the hypochromia minus microcytosis (H-M) index, and the discriminant function (DF). The diagnostic accuracy of the erythrogram pattern was 83.3% for alpha-thalassaemia trait and 95.3% for beta-thalassaemia trait. The diagnostic accuracy for the H-M index was 19.4% for alpha-thalassaemia trait, 72.1% for beta-thalassaemia trait and 91.1% for iron deficiency. By comparison, the DF gave a diagnostic accuracy of 75.0% for alpha-thalassaemia trait, 81.4% for beta-thalassaemia trait and 88.9% for iron deficiency when using a locally derived value for the constant (k) = 19.2. Our study shows that the H*1 erythrogram pattern, the H-M index and the DF are useful predictive indicators in routine laboratory screening for thalassaemia. | en_US |
dc.language | eng | en_US |
dc.relation.ispartof | Medical Laboratory Sciences | en_US |
dc.subject | Anemia, hypochromic | - |
dc.subject | Blood cell count | - |
dc.subject | Discriminant analysis | - |
dc.subject | Thalassemia | - |
dc.subject.mesh | Discriminant Analysis | en_US |
dc.subject.mesh | Erythrocyte Count - Instrumentation - Methods | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Retrospective Studies | en_US |
dc.subject.mesh | Sensitivity And Specificity | en_US |
dc.subject.mesh | Thalassemia - Diagnosis | en_US |
dc.title | Use of Technicon H*1 technology in routine thalassaemia screening | en_US |
dc.type | Article | en_US |
dc.identifier.email | Chan, LC:chanlc@hkucc.hku.hk | en_US |
dc.identifier.authority | Chan, LC=rp00373 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.pmid | 1339929 | - |
dc.identifier.scopus | eid_2-s2.0-0027008368 | en_US |
dc.identifier.volume | 49 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.spage | 259 | en_US |
dc.identifier.epage | 264 | en_US |
dc.identifier.isi | WOS:A1992KH16100006 | - |
dc.identifier.issnl | 0308-3616 | - |