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Article: Use of Technicon H*1 technology in routine thalassaemia screening

TitleUse of Technicon H*1 technology in routine thalassaemia screening
Authors
Issue Date1992
Citation
Medical Laboratory Sciences, 1992, v. 49 n. 4, p. 259-264 How to Cite?
AbstractIn a retrospective study of 36 cases of alpha-thalassaemia trait, 43 cases of beta-thalassaemia trait and 45 cases of iron deficiency, we have assessed the performance of the Technicon H*1 erythrogram, the hypochromia minus microcytosis (H-M) index, and the discriminant function (DF). The diagnostic accuracy of the erythrogram pattern was 83.3% for alpha-thalassaemia trait and 95.3% for beta-thalassaemia trait. The diagnostic accuracy for the H-M index was 19.4% for alpha-thalassaemia trait, 72.1% for beta-thalassaemia trait and 91.1% for iron deficiency. By comparison, the DF gave a diagnostic accuracy of 75.0% for alpha-thalassaemia trait, 81.4% for beta-thalassaemia trait and 88.9% for iron deficiency when using a locally derived value for the constant (k) = 19.2. Our study shows that the H*1 erythrogram pattern, the H-M index and the DF are useful predictive indicators in routine laboratory screening for thalassaemia.
Persistent Identifierhttp://hdl.handle.net/10722/147942
ISSN
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorRobertson, EPen_US
dc.contributor.authorPollock, Aen_US
dc.contributor.authorYau, KSen_US
dc.contributor.authorChan, LCen_US
dc.date.accessioned2012-05-29T06:10:01Z-
dc.date.available2012-05-29T06:10:01Z-
dc.date.issued1992en_US
dc.identifier.citationMedical Laboratory Sciences, 1992, v. 49 n. 4, p. 259-264en_US
dc.identifier.issn0308-3616en_US
dc.identifier.urihttp://hdl.handle.net/10722/147942-
dc.description.abstractIn a retrospective study of 36 cases of alpha-thalassaemia trait, 43 cases of beta-thalassaemia trait and 45 cases of iron deficiency, we have assessed the performance of the Technicon H*1 erythrogram, the hypochromia minus microcytosis (H-M) index, and the discriminant function (DF). The diagnostic accuracy of the erythrogram pattern was 83.3% for alpha-thalassaemia trait and 95.3% for beta-thalassaemia trait. The diagnostic accuracy for the H-M index was 19.4% for alpha-thalassaemia trait, 72.1% for beta-thalassaemia trait and 91.1% for iron deficiency. By comparison, the DF gave a diagnostic accuracy of 75.0% for alpha-thalassaemia trait, 81.4% for beta-thalassaemia trait and 88.9% for iron deficiency when using a locally derived value for the constant (k) = 19.2. Our study shows that the H*1 erythrogram pattern, the H-M index and the DF are useful predictive indicators in routine laboratory screening for thalassaemia.en_US
dc.languageengen_US
dc.relation.ispartofMedical Laboratory Sciencesen_US
dc.subject.meshDiscriminant Analysisen_US
dc.subject.meshErythrocyte Count - Instrumentation - Methodsen_US
dc.subject.meshHumansen_US
dc.subject.meshRetrospective Studiesen_US
dc.subject.meshSensitivity And Specificityen_US
dc.subject.meshThalassemia - Diagnosisen_US
dc.titleUse of Technicon H*1 technology in routine thalassaemia screeningen_US
dc.typeArticleen_US
dc.identifier.emailChan, LC:chanlc@hkucc.hku.hken_US
dc.identifier.authorityChan, LC=rp00373en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid1339929-
dc.identifier.scopuseid_2-s2.0-0027008368en_US
dc.identifier.volume49en_US
dc.identifier.issue4en_US
dc.identifier.spage259en_US
dc.identifier.epage264en_US
dc.identifier.isiWOS:A1992KH16100006-

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