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Article: Radiation therapy for nasopharyngeal carcinoma: Histologic appearances and patterns of tumor regression

TitleRadiation therapy for nasopharyngeal carcinoma: Histologic appearances and patterns of tumor regression
Authors
Issue Date1992
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/humpath
Citation
Human Pathology, 1992, v. 23 n. 7, p. 742-747 How to Cite?
AbstractNasopharyngeal carcinoma is a common malignancy in Hong Kong and is treated by external radiotherapy. After 6.5 weeks of radiotherapy, the nasopharynx of 100 patients was examined and biopsy specimens were taken. All patients had repeated examination and biopsies done every 2 weeks until exophytic tumor was not seen and biopsy samples were negative on more than one examination of the nasopharynx. The interval between the cessation of therapy and biopsy ranged from 1 day to 11 weeks. Twenty-three patients had atypical findings and five of these had residual tumor requiring gold grain implantation brachytherapy. We identified a number of distinct pathologic changes in the postbiopsy material. Most of these changes disappeared 8 weeks after the cessation of therapy, but the presence of residual tumor after this time was an indication for subsequent therapy. If the date of the first biopsy was delayed until 6 weeks after the completion of radiotherapy, the percentage of atypical biopsies containing residual tumor rose from 21% to 55%. The posttreatment biopsy should be performed twice, as four patients had negative biopsy findings due to sampling error.
Persistent Identifierhttp://hdl.handle.net/10722/147937
ISSN
2015 Impact Factor: 2.791
2015 SCImago Journal Rankings: 1.363
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorNicholls, JMen_US
dc.contributor.authorSham, Jen_US
dc.contributor.authorChan, CWen_US
dc.contributor.authorChoy, Den_US
dc.date.accessioned2012-05-29T06:10:00Z-
dc.date.available2012-05-29T06:10:00Z-
dc.date.issued1992en_US
dc.identifier.citationHuman Pathology, 1992, v. 23 n. 7, p. 742-747en_US
dc.identifier.issn0046-8177en_US
dc.identifier.urihttp://hdl.handle.net/10722/147937-
dc.description.abstractNasopharyngeal carcinoma is a common malignancy in Hong Kong and is treated by external radiotherapy. After 6.5 weeks of radiotherapy, the nasopharynx of 100 patients was examined and biopsy specimens were taken. All patients had repeated examination and biopsies done every 2 weeks until exophytic tumor was not seen and biopsy samples were negative on more than one examination of the nasopharynx. The interval between the cessation of therapy and biopsy ranged from 1 day to 11 weeks. Twenty-three patients had atypical findings and five of these had residual tumor requiring gold grain implantation brachytherapy. We identified a number of distinct pathologic changes in the postbiopsy material. Most of these changes disappeared 8 weeks after the cessation of therapy, but the presence of residual tumor after this time was an indication for subsequent therapy. If the date of the first biopsy was delayed until 6 weeks after the completion of radiotherapy, the percentage of atypical biopsies containing residual tumor rose from 21% to 55%. The posttreatment biopsy should be performed twice, as four patients had negative biopsy findings due to sampling error.en_US
dc.languageengen_US
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/humpathen_US
dc.relation.ispartofHuman Pathologyen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshCarcinoma - Pathology - Radiotherapyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNasopharyngeal Neoplasms - Pathology - Radiotherapyen_US
dc.subject.meshRemission Inductionen_US
dc.titleRadiation therapy for nasopharyngeal carcinoma: Histologic appearances and patterns of tumor regressionen_US
dc.typeArticleen_US
dc.identifier.emailNicholls, JM:nicholls@pathology.hku.hken_US
dc.identifier.authorityNicholls, JM=rp00364en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0046-8177(92)90342-Zen_US
dc.identifier.pmid1612574-
dc.identifier.scopuseid_2-s2.0-0026747822en_US
dc.identifier.volume23en_US
dc.identifier.issue7en_US
dc.identifier.spage742en_US
dc.identifier.epage747en_US
dc.identifier.isiWOS:A1992JD20300006-
dc.publisher.placeUnited Statesen_US

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