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Article: Human papillomavirus and its prognostic significance in invasive carcinoma of the cervix in young patients

TitleHuman papillomavirus and its prognostic significance in invasive carcinoma of the cervix in young patients
Authors
Issue Date1992
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.intjgynpathology.com
Citation
International Journal Of Gynecological Pathology, 1992, v. 11 n. 4, p. 258-265 How to Cite?
AbstractOf 1,200 Chinese patients treated for carcinoma of the cervix between 1975 and 1984, those aged 40 years (n = 70) or less had a poorer prognosis. Of the latter group, 71% had disease classified as less than International Federation of Gynecology and Obstetrics (FIGO) stage Ib, and in 91% the disease was less than stage IIa; however, the 5-year survival of the 45 patients with verified invasive carcinoma was 75% compared with 82% for the overall group. The polymerase chain reaction (PCR) was used to test for the presence of human papilloma virus (HPV) types 16 and 18 within paraffin-embedded tissue from the primary tumors. HPV-16 DNA sequences were detected in 69% of the cases, HPV-18 DNA sequences in 44%, and in 31% both HPV-16 and -18 DNA could be identified. Of the cases of invasive carcinoma, 82% (37 of 45) contained DNA of HPV types 16 and/or 18. The effects of the presence or absence of HPV DNA on known prognostic factors was investigated. Although the influence of traditional factors, especially lymph node involvement, was confirmed, careful statistical analysis could not demonstrate a prognostic influence for HPV-16/18.
Persistent Identifierhttp://hdl.handle.net/10722/147936
ISSN
2015 Impact Factor: 1.437
2015 SCImago Journal Rankings: 0.723
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorIp, EWKen_US
dc.contributor.authorCollins, RJen_US
dc.contributor.authorSrivastava, Gen_US
dc.contributor.authorCheung, ANYen_US
dc.contributor.authorWong, LCen_US
dc.date.accessioned2012-05-29T06:09:59Z-
dc.date.available2012-05-29T06:09:59Z-
dc.date.issued1992en_US
dc.identifier.citationInternational Journal Of Gynecological Pathology, 1992, v. 11 n. 4, p. 258-265en_US
dc.identifier.issn0277-1691en_US
dc.identifier.urihttp://hdl.handle.net/10722/147936-
dc.description.abstractOf 1,200 Chinese patients treated for carcinoma of the cervix between 1975 and 1984, those aged 40 years (n = 70) or less had a poorer prognosis. Of the latter group, 71% had disease classified as less than International Federation of Gynecology and Obstetrics (FIGO) stage Ib, and in 91% the disease was less than stage IIa; however, the 5-year survival of the 45 patients with verified invasive carcinoma was 75% compared with 82% for the overall group. The polymerase chain reaction (PCR) was used to test for the presence of human papilloma virus (HPV) types 16 and 18 within paraffin-embedded tissue from the primary tumors. HPV-16 DNA sequences were detected in 69% of the cases, HPV-18 DNA sequences in 44%, and in 31% both HPV-16 and -18 DNA could be identified. Of the cases of invasive carcinoma, 82% (37 of 45) contained DNA of HPV types 16 and/or 18. The effects of the presence or absence of HPV DNA on known prognostic factors was investigated. Although the influence of traditional factors, especially lymph node involvement, was confirmed, careful statistical analysis could not demonstrate a prognostic influence for HPV-16/18.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.intjgynpathology.comen_US
dc.relation.ispartofInternational Journal of Gynecological Pathologyen_US
dc.subject.meshAdulten_US
dc.subject.meshBase Sequenceen_US
dc.subject.meshCarcinoma - Complications - Mortalityen_US
dc.subject.meshDna Probes, Hpven_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshPapillomaviridae - Isolation & Purificationen_US
dc.subject.meshPrognosisen_US
dc.subject.meshSurvival Rateen_US
dc.subject.meshTumor Virus Infections - Mortalityen_US
dc.subject.meshUterine Cervical Neoplasms - Complications - Mortalityen_US
dc.titleHuman papillomavirus and its prognostic significance in invasive carcinoma of the cervix in young patientsen_US
dc.typeArticleen_US
dc.identifier.emailCollins, RJ:rcollins@hkucc.hku.hken_US
dc.identifier.emailSrivastava, G:gopesh@pathology.hku.hken_US
dc.identifier.emailCheung, ANY:anycheun@hkucc.hku.hken_US
dc.identifier.authorityCollins, RJ=rp00251en_US
dc.identifier.authoritySrivastava, G=rp00365en_US
dc.identifier.authorityCheung, ANY=rp00542en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid1328083-
dc.identifier.scopuseid_2-s2.0-0026746535en_US
dc.identifier.volume11en_US
dc.identifier.issue4en_US
dc.identifier.spage258en_US
dc.identifier.epage265en_US
dc.identifier.isiWOS:A1992JQ18800003-
dc.publisher.placeUnited Statesen_US

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