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Article: Interferon treatment for hepatitis B-associated membranous glomerulonephritis in two Chinese children

TitleInterferon treatment for hepatitis B-associated membranous glomerulonephritis in two Chinese children
Authors
KeywordsHepatitis B virus infection
Interferon
Membranous nephropathy
Issue Date1992
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00467/index.htm
Citation
Pediatric Nephrology, 1992, v. 6 n. 5, p. 417-420 How to Cite?
AbstractTwo Chinese boys, aged 3.5 and 5 years, developed nephrotic syndrome and were chronic carriers of hepatitis B virus surface antigen (HBsAg) and hepatitis B virus e antigen (HBeAg). Renal biopsy showed membranous glomerulonephritis and liver biopsy showed chronic persistent hepatitis. They were given interferon-α-2a at a dose of 5MU/m 2 on alternate days for 12 and 16 weeks after 2 years of persistent nephrotic syndrome. Patient 1 showed complete remission and resolution of hepatosplenomegaly, but his serum remained positive for HBsAg, HBeAg and hepatitis B virus DNA. Patient 2 showed only a transient clinical response and seroconversion from HBeAg to anti-HBe status. Although not always successful, interferon treatment should be considered in severe persistent nephrotic states, since there is at present no satisfactory treatment for this form of glomerulonephropathy.
Persistent Identifierhttp://hdl.handle.net/10722/147925
ISSN
2015 Impact Factor: 2.338
2015 SCImago Journal Rankings: 0.959
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWong, SNen_HK
dc.contributor.authorYu, ECLen_HK
dc.contributor.authorLok, ASFen_HK
dc.contributor.authorChan, KWen_HK
dc.contributor.authorLau, YLen_HK
dc.date.accessioned2012-05-29T06:09:56Z-
dc.date.available2012-05-29T06:09:56Z-
dc.date.issued1992en_HK
dc.identifier.citationPediatric Nephrology, 1992, v. 6 n. 5, p. 417-420en_HK
dc.identifier.issn0931-041Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/147925-
dc.description.abstractTwo Chinese boys, aged 3.5 and 5 years, developed nephrotic syndrome and were chronic carriers of hepatitis B virus surface antigen (HBsAg) and hepatitis B virus e antigen (HBeAg). Renal biopsy showed membranous glomerulonephritis and liver biopsy showed chronic persistent hepatitis. They were given interferon-α-2a at a dose of 5MU/m 2 on alternate days for 12 and 16 weeks after 2 years of persistent nephrotic syndrome. Patient 1 showed complete remission and resolution of hepatosplenomegaly, but his serum remained positive for HBsAg, HBeAg and hepatitis B virus DNA. Patient 2 showed only a transient clinical response and seroconversion from HBeAg to anti-HBe status. Although not always successful, interferon treatment should be considered in severe persistent nephrotic states, since there is at present no satisfactory treatment for this form of glomerulonephropathy.en_HK
dc.languageengen_US
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00467/index.htmen_HK
dc.relation.ispartofPediatric Nephrologyen_HK
dc.subjectHepatitis B virus infectionen_HK
dc.subjectInterferonen_HK
dc.subjectMembranous nephropathyen_HK
dc.subject.meshBiopsyen_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshDna, Viral - Analysisen_US
dc.subject.meshGlomerulonephritis, Membranous - Complications - Drug Therapy - Epidemiologyen_US
dc.subject.meshHepatitis B - Complications - Drug Therapy - Epidemiologyen_US
dc.subject.meshHepatitis B Surface Antigens - Analysisen_US
dc.subject.meshHepatitis B E Antigens - Analysisen_US
dc.subject.meshHepatitis B Virus - Geneticsen_US
dc.subject.meshHong Kong - Epidemiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshInterferons - Therapeutic Useen_US
dc.subject.meshKidney - Pathologyen_US
dc.subject.meshMaleen_US
dc.titleInterferon treatment for hepatitis B-associated membranous glomerulonephritis in two Chinese childrenen_HK
dc.typeArticleen_HK
dc.identifier.emailChan, KW:hrmtckw@hku.hken_HK
dc.identifier.emailLau, YL:lauylung@hkucc.hku.hken_HK
dc.identifier.authorityChan, KW=rp00330en_HK
dc.identifier.authorityLau, YL=rp00361en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/BF00873997en_HK
dc.identifier.pmid1280987-
dc.identifier.scopuseid_2-s2.0-0026663176en_HK
dc.identifier.volume6en_HK
dc.identifier.issue5en_HK
dc.identifier.spage417en_HK
dc.identifier.epage420en_HK
dc.identifier.isiWOS:A1992JP20100003-
dc.publisher.placeGermanyen_HK
dc.identifier.scopusauthoridWong, SN=7404590305en_HK
dc.identifier.scopusauthoridYu, ECL=16154697300en_HK
dc.identifier.scopusauthoridLok, ASF=35379868500en_HK
dc.identifier.scopusauthoridChan, KW=16444133100en_HK
dc.identifier.scopusauthoridLau, YL=7201403380en_HK

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