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Article: Incidence of ras oncogene activation in lung carcinomas in Hong Kong

TitleIncidence of ras oncogene activation in lung carcinomas in Hong Kong
Authors
Keywordsadenocarcinoma
lung
non-small cell lung carcinoma
point mutation
ras oncogene
Issue Date1992
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741
Citation
Cancer, 1992, v. 70 n. 4, p. 760-763 How to Cite?
AbstractBackground. In Hong Kong, lung carcinomas contribute to the majority of cancer deaths among Chinese. Point mutational activation of ras oncogenes has been observed in several populations. The incidence of these mutations in Hong Kong lung carcinomas was investigated. Methods. Lung resections obtained from 52 Chinese patients whose conditions were newly diagnosed as non-small cell lung cancer, paraffin sections from 29 Chinese patients with previously diagnosed adenocarcinoma of the lung, and paraffin sections from 49 squamous cell carcinomas were examined for the presence of point mutations in Ki-ras codon 12, N-ras codon 61, and Ha-ras codon 12 oncogenes by allele-specific hybridization after specific amplification of appropriate regions of the DNA using the polymerase chain reaction. Results. Among the 130 lung carcinomas investigated, Ki-ras point mutations were detected in seven cases, of which six were adenocarcinomas and one a squamous cell carcinoma. No mutations were detected in the N-ras and Ha-ras codons. Conclusions. The incidence of Ki-ras codon 12 point mutational activation in Chinese patients with adenocarcinomas was 6 of 63 (9.5%). The incidence of Ki-ras 12 point mutational activation among men with lung adenocarcinomas in Hong Kong (6 of 32 patients, 18.8%) is significantly different from that in women in Hong Kong (0 of 31 patients, 0%). Although ras oncogenes are implicated as having a role in the development of lung adenocarcinomas, especially among smokers, it is clear from these data that they are not associated with the unusually high incidence of lung adenocarcinomas among women in Hong Kong.
Persistent Identifierhttp://hdl.handle.net/10722/147924
ISSN
2015 Impact Factor: 5.649
2015 SCImago Journal Rankings: 3.188
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLung, MLen_HK
dc.contributor.authorWong, Men_HK
dc.contributor.authorWah Kit Lamen_HK
dc.contributor.authorKam Shing Lauen_HK
dc.contributor.authorKwan, Sen_HK
dc.contributor.authorFu, KHen_HK
dc.contributor.authorCheung, Hen_HK
dc.contributor.authorWing Wei Yewen_HK
dc.date.accessioned2012-05-29T06:09:56Z-
dc.date.available2012-05-29T06:09:56Z-
dc.date.issued1992en_HK
dc.identifier.citationCancer, 1992, v. 70 n. 4, p. 760-763en_HK
dc.identifier.issn0008-543Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/147924-
dc.description.abstractBackground. In Hong Kong, lung carcinomas contribute to the majority of cancer deaths among Chinese. Point mutational activation of ras oncogenes has been observed in several populations. The incidence of these mutations in Hong Kong lung carcinomas was investigated. Methods. Lung resections obtained from 52 Chinese patients whose conditions were newly diagnosed as non-small cell lung cancer, paraffin sections from 29 Chinese patients with previously diagnosed adenocarcinoma of the lung, and paraffin sections from 49 squamous cell carcinomas were examined for the presence of point mutations in Ki-ras codon 12, N-ras codon 61, and Ha-ras codon 12 oncogenes by allele-specific hybridization after specific amplification of appropriate regions of the DNA using the polymerase chain reaction. Results. Among the 130 lung carcinomas investigated, Ki-ras point mutations were detected in seven cases, of which six were adenocarcinomas and one a squamous cell carcinoma. No mutations were detected in the N-ras and Ha-ras codons. Conclusions. The incidence of Ki-ras codon 12 point mutational activation in Chinese patients with adenocarcinomas was 6 of 63 (9.5%). The incidence of Ki-ras 12 point mutational activation among men with lung adenocarcinomas in Hong Kong (6 of 32 patients, 18.8%) is significantly different from that in women in Hong Kong (0 of 31 patients, 0%). Although ras oncogenes are implicated as having a role in the development of lung adenocarcinomas, especially among smokers, it is clear from these data that they are not associated with the unusually high incidence of lung adenocarcinomas among women in Hong Kong.en_HK
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741en_HK
dc.relation.ispartofCanceren_HK
dc.subjectadenocarcinomaen_HK
dc.subjectlungen_HK
dc.subjectnon-small cell lung carcinomaen_HK
dc.subjectpoint mutationen_HK
dc.subjectras oncogeneen_HK
dc.subject.meshAdenocarcinoma - Epidemiology - Genetics - Pathologyen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshCarcinoma, Non-Small-Cell Lung - Epidemiology - Genetics - Pathologyen_US
dc.subject.meshCarcinoma, Squamous Cell - Epidemiology - Genetics - Pathologyen_US
dc.subject.meshCodon - Geneticsen_US
dc.subject.meshDna Probesen_US
dc.subject.meshFemaleen_US
dc.subject.meshGene Expression Regulation, Neoplastic - Geneticsen_US
dc.subject.meshGenes, Ras - Geneticsen_US
dc.subject.meshHong Kong - Epidemiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunoblottingen_US
dc.subject.meshIncidenceen_US
dc.subject.meshLung Neoplasms - Epidemiology - Genetics - Pathologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMutation - Geneticsen_US
dc.subject.meshPolymerase Chain Reactionen_US
dc.titleIncidence of ras oncogene activation in lung carcinomas in Hong Kongen_HK
dc.typeArticleen_HK
dc.identifier.emailLung, ML:mlilung@hku.hken_HK
dc.identifier.emailWong, M:mwpik@hkucc.hku.hken_HK
dc.identifier.authorityLung, ML=rp00300en_HK
dc.identifier.authorityWong, M=rp00348en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/1097-0142(19920815)70:4<760::AID-CNCR2820700407>3.0.CO;2-0en_HK
dc.identifier.pmid1322782-
dc.identifier.scopuseid_2-s2.0-0026654428en_HK
dc.identifier.volume70en_HK
dc.identifier.issue4en_HK
dc.identifier.spage760en_HK
dc.identifier.epage763en_HK
dc.identifier.isiWOS:A1992JH65400006-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLung, ML=7006411788en_HK
dc.identifier.scopusauthoridWong, M=7403907887en_HK
dc.identifier.scopusauthoridWah Kit Lam=16155038500en_HK
dc.identifier.scopusauthoridKam Shing Lau=16151047300en_HK
dc.identifier.scopusauthoridKwan, S=35891301600en_HK
dc.identifier.scopusauthoridFu, KH=7202283800en_HK
dc.identifier.scopusauthoridCheung, H=19638396400en_HK
dc.identifier.scopusauthoridWing Wei Yew=16154561100en_HK

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