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Article: Detection of clonal Epstein-Barr virus in malignant proliferation of peripheral blood CD3+ CD8+ T cells

TitleDetection of clonal Epstein-Barr virus in malignant proliferation of peripheral blood CD3+ CD8+ T cells
Authors
Issue Date1992
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/leu
Citation
Leukemia, 1992, v. 6 n. 9, p. 952-956 How to Cite?
AbstractEpstein Barr virus (EBV) DNA was detected in a monoclonal proliferation of T cells in a three-year-old girl who presented with a history of fever, hepatosplenomegaly, and generalised lymphadenopathy. The disease ran a rapid, fulminant course and the patient died 11 days after presentation. Examination of the blood showed a lymphocytosis of 50 x 109/l with all the cells showing the morphology of large granular lymphocytes. These cells were CD2+3+8+25+. Cytogenetic studies showed the presence of a 6q- clone. Southern blotting and hybridisation with a constant region probe for the T-cell receptor (TCR) β chain gene showed clonal rearrangement of the TCRβ gene. Hybridisation of the Southern blot to the EBV Xho1 probe revealed a clonal pattern of episomal EBV DNA. Our results establish the association between clonal EBV infection to a malignant proliferation of peripheral blood CD8+ T cells.
Persistent Identifierhttp://hdl.handle.net/10722/147922
ISSN
2015 Impact Factor: 12.104
2015 SCImago Journal Rankings: 5.142
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChan, LCen_HK
dc.contributor.authorSrivastava, Gen_HK
dc.contributor.authorPittaluga, Sen_HK
dc.contributor.authorKwong, YLen_HK
dc.contributor.authorLiu, HWen_HK
dc.contributor.authorYuen, HLen_HK
dc.date.accessioned2012-05-29T06:09:55Z-
dc.date.available2012-05-29T06:09:55Z-
dc.date.issued1992en_HK
dc.identifier.citationLeukemia, 1992, v. 6 n. 9, p. 952-956en_HK
dc.identifier.issn0887-6924en_HK
dc.identifier.urihttp://hdl.handle.net/10722/147922-
dc.description.abstractEpstein Barr virus (EBV) DNA was detected in a monoclonal proliferation of T cells in a three-year-old girl who presented with a history of fever, hepatosplenomegaly, and generalised lymphadenopathy. The disease ran a rapid, fulminant course and the patient died 11 days after presentation. Examination of the blood showed a lymphocytosis of 50 x 109/l with all the cells showing the morphology of large granular lymphocytes. These cells were CD2+3+8+25+. Cytogenetic studies showed the presence of a 6q- clone. Southern blotting and hybridisation with a constant region probe for the T-cell receptor (TCR) β chain gene showed clonal rearrangement of the TCRβ gene. Hybridisation of the Southern blot to the EBV Xho1 probe revealed a clonal pattern of episomal EBV DNA. Our results establish the association between clonal EBV infection to a malignant proliferation of peripheral blood CD8+ T cells.en_HK
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/leuen_HK
dc.relation.ispartofLeukemiaen_HK
dc.subject.meshAntigens, Cd3en_US
dc.subject.meshAntigens, Cd8 - Metabolismen_US
dc.subject.meshAntigens, Differentiation, T-Lymphocyte - Metabolismen_US
dc.subject.meshBlotting, Southernen_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshDna, Viral - Analysisen_US
dc.subject.meshFemaleen_US
dc.subject.meshGene Rearrangement, Beta-Chain T-Cell Antigen Receptoren_US
dc.subject.meshHerpesvirus 4, Human - Genetics - Isolation & Purificationen_US
dc.subject.meshHumansen_US
dc.subject.meshLymphocytosis - Genetics - Immunology - Microbiologyen_US
dc.subject.meshReceptors, Antigen, T-Cell - Metabolismen_US
dc.subject.meshT-Lymphocytes - Immunology - Pathologyen_US
dc.subject.meshTumor Virus Infections - Genetics - Immunology - Microbiologyen_US
dc.titleDetection of clonal Epstein-Barr virus in malignant proliferation of peripheral blood CD3+ CD8+ T cellsen_HK
dc.typeArticleen_HK
dc.identifier.emailChan, LC:chanlc@hkucc.hku.hken_HK
dc.identifier.emailSrivastava, G:gopesh@pathology.hku.hken_HK
dc.identifier.emailKwong, YL:ylkwong@hku.hken_HK
dc.identifier.authorityChan, LC=rp00373en_HK
dc.identifier.authoritySrivastava, G=rp00365en_HK
dc.identifier.authorityKwong, YL=rp00358en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid1325583-
dc.identifier.scopuseid_2-s2.0-0026640540en_HK
dc.identifier.volume6en_HK
dc.identifier.issue9en_HK
dc.identifier.spage952en_HK
dc.identifier.epage956en_HK
dc.identifier.isiWOS:A1992JP81000015-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridChan, LC=7403540707en_HK
dc.identifier.scopusauthoridSrivastava, G=7202242238en_HK
dc.identifier.scopusauthoridPittaluga, S=7006897513en_HK
dc.identifier.scopusauthoridKwong, YL=7102818954en_HK
dc.identifier.scopusauthoridLiu, HW=7409752648en_HK
dc.identifier.scopusauthoridYuen, HL=36914136400en_HK

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