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Article: Presence of Epstein-Barr virus DNA in nasal lymphomas of B and 'T' cell type

TitlePresence of Epstein-Barr virus DNA in nasal lymphomas of B and 'T' cell type
Authors
Issue Date1990
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/3182
Citation
Hematological Oncology, 1990, v. 8 n. 5, p. 271-281 How to Cite?
AbstractWe studied 12 tumours from 11 Chinese patients with primary nasal lymphoma for presence of Epstein-Barr Virus (EBV) DNA, using Southern-blot analysis. These results were correlated with immunophenotype and T-cell receptor (TcR) or immunoglobulin gene rearrangement patterns. EBV DNA was detected in all nine tumours with a 'T' phenotype, in both primary and secondary sites. When the structure of the viral genomic termini was studied using the EcoRI-Dhet probe, a single clonal episomal band was demonstrated in five tumour samples, with one other case showing a biclonal pattern. However, none of these cases showed clonal rearrangement of TcR(β) chain gene, and TcR(Å) rearrangement was found only in one. The lineage of these phenotypic 'T' lymphomas therefore require further studies for confirmation. Two out of three B-lymphomas were also EBV DNA+; clonal EBV DNA was found in one. Their B-lineage was confirmed by detection of clonal immunoglobulin gene rearrangements. The association of EBV with an increasing number of lymphomas of different types highlights the need for continued study into its role in oncogenesis .
Persistent Identifierhttp://hdl.handle.net/10722/147862
ISSN
2015 Impact Factor: 3.494
2015 SCImago Journal Rankings: 0.767
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHo, FCSen_HK
dc.contributor.authorSrivastava, Gen_HK
dc.contributor.authorLoke, SLen_HK
dc.contributor.authorFu, KHen_HK
dc.contributor.authorLeung, BPYen_HK
dc.contributor.authorLiang, Ren_HK
dc.contributor.authorChoy, Den_HK
dc.date.accessioned2012-05-29T06:09:37Z-
dc.date.available2012-05-29T06:09:37Z-
dc.date.issued1990en_HK
dc.identifier.citationHematological Oncology, 1990, v. 8 n. 5, p. 271-281en_HK
dc.identifier.issn0278-0232en_HK
dc.identifier.urihttp://hdl.handle.net/10722/147862-
dc.description.abstractWe studied 12 tumours from 11 Chinese patients with primary nasal lymphoma for presence of Epstein-Barr Virus (EBV) DNA, using Southern-blot analysis. These results were correlated with immunophenotype and T-cell receptor (TcR) or immunoglobulin gene rearrangement patterns. EBV DNA was detected in all nine tumours with a 'T' phenotype, in both primary and secondary sites. When the structure of the viral genomic termini was studied using the EcoRI-Dhet probe, a single clonal episomal band was demonstrated in five tumour samples, with one other case showing a biclonal pattern. However, none of these cases showed clonal rearrangement of TcR(β) chain gene, and TcR(Å) rearrangement was found only in one. The lineage of these phenotypic 'T' lymphomas therefore require further studies for confirmation. Two out of three B-lymphomas were also EBV DNA+; clonal EBV DNA was found in one. Their B-lineage was confirmed by detection of clonal immunoglobulin gene rearrangements. The association of EBV with an increasing number of lymphomas of different types highlights the need for continued study into its role in oncogenesis .en_HK
dc.languageengen_US
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/3182en_HK
dc.relation.ispartofHematological Oncologyen_HK
dc.subject.meshBlotting, Southernen_US
dc.subject.meshChinaen_US
dc.subject.meshDna - Analysisen_US
dc.subject.meshDna Probesen_US
dc.subject.meshGene Expression Regulation, Viralen_US
dc.subject.meshGene Rearrangementen_US
dc.subject.meshHerpesvirus 4, Human - Geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshLymphoma, B-Cell - Genetics - Immunology - Microbiologyen_US
dc.subject.meshLymphoma, T-Cell - Genetics - Immunology - Microbiologyen_US
dc.subject.meshNasopharyngeal Neoplasms - Genetics - Immunology - Microbiologyen_US
dc.subject.meshPhenotypeen_US
dc.subject.meshPolymorphism, Restriction Fragment Lengthen_US
dc.titlePresence of Epstein-Barr virus DNA in nasal lymphomas of B and 'T' cell typeen_HK
dc.typeArticleen_HK
dc.identifier.emailSrivastava, G:gopesh@pathology.hku.hken_HK
dc.identifier.emailLiang, R:rliang@hku.hken_HK
dc.identifier.authoritySrivastava, G=rp00365en_HK
dc.identifier.authorityLiang, R=rp00345en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/hon.2900080505en_HK
dc.identifier.pmid1979042-
dc.identifier.scopuseid_2-s2.0-0025203929en_HK
dc.identifier.volume8en_HK
dc.identifier.issue5en_HK
dc.identifier.spage271en_HK
dc.identifier.epage281en_HK
dc.identifier.isiWOS:A1990EK90200004-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridHo, FCS=7103408147en_HK
dc.identifier.scopusauthoridSrivastava, G=7202242238en_HK
dc.identifier.scopusauthoridLoke, SL=7006559512en_HK
dc.identifier.scopusauthoridFu, KH=7202283800en_HK
dc.identifier.scopusauthoridLeung, BPY=7102271395en_HK
dc.identifier.scopusauthoridLiang, R=26643224900en_HK
dc.identifier.scopusauthoridChoy, D=8663654500en_HK

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