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Article: Mesangial IgA nephropathy with steroid-responsive nephrotic syndrome: Disappearance of mesangial IgA deposits following steroid-induced remission

TitleMesangial IgA nephropathy with steroid-responsive nephrotic syndrome: Disappearance of mesangial IgA deposits following steroid-induced remission
Authors
Issue Date1989
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/ajkd
Citation
American Journal Of Kidney Diseases, 1989, v. 14 n. 5, p. 361-364 How to Cite?
AbstractThis report describes the clinical features and renal biopsy pathology in two patients with immunoglobulin A (IgA) nephropathy and nephrotic syndrome before and after steroid-induced remission. Apart from confirming the frequently relapsing course and mild glomerular changes observed in patients with IgA nephropathy and steroid-responsive nephrotic syndrome (SRNS), we were able to show that mesangial expansion and mesangial IgA deposits disappeared or were greatly reduced in repeat renal biopsies following steroid-induced remission. Because mesangial IgA deposits usually persist in repeat biopsies obtained from patients with typical IgA nephropathy, their resolution in our patients following steroid remission would support the proposal that the association of IgA nephropathy and SRNS may represent a distinct clinical syndrome. It is postulated that the presence of mesangial IgA deposits during nephrotic presentation and their disappearance following steroid-induced remission may result from increased mesangial sequestration of IgA circulating immune complexes (CIC) during the period of enhanced glomerular permeability and that the increased load of IgA CICs may reflect a common defect in mucosal immunity or immunoregulation in these patients.
Persistent Identifierhttp://hdl.handle.net/10722/147846
ISSN
2015 Impact Factor: 6.269
2015 SCImago Journal Rankings: 2.313
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorCheng, IKPen_US
dc.contributor.authorChan, KWen_US
dc.contributor.authorChan, MKen_US
dc.date.accessioned2012-05-29T06:09:32Z-
dc.date.available2012-05-29T06:09:32Z-
dc.date.issued1989en_US
dc.identifier.citationAmerican Journal Of Kidney Diseases, 1989, v. 14 n. 5, p. 361-364en_US
dc.identifier.issn0272-6386en_US
dc.identifier.urihttp://hdl.handle.net/10722/147846-
dc.description.abstractThis report describes the clinical features and renal biopsy pathology in two patients with immunoglobulin A (IgA) nephropathy and nephrotic syndrome before and after steroid-induced remission. Apart from confirming the frequently relapsing course and mild glomerular changes observed in patients with IgA nephropathy and steroid-responsive nephrotic syndrome (SRNS), we were able to show that mesangial expansion and mesangial IgA deposits disappeared or were greatly reduced in repeat renal biopsies following steroid-induced remission. Because mesangial IgA deposits usually persist in repeat biopsies obtained from patients with typical IgA nephropathy, their resolution in our patients following steroid remission would support the proposal that the association of IgA nephropathy and SRNS may represent a distinct clinical syndrome. It is postulated that the presence of mesangial IgA deposits during nephrotic presentation and their disappearance following steroid-induced remission may result from increased mesangial sequestration of IgA circulating immune complexes (CIC) during the period of enhanced glomerular permeability and that the increased load of IgA CICs may reflect a common defect in mucosal immunity or immunoregulation in these patients.en_US
dc.languageengen_US
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/ajkden_US
dc.relation.ispartofAmerican Journal of Kidney Diseasesen_US
dc.subject.meshAdulten_US
dc.subject.meshBiopsyen_US
dc.subject.meshFemaleen_US
dc.subject.meshGlomerular Mesangium - Metabolismen_US
dc.subject.meshGlomerulonephritis, Iga - Complications - Drug Therapy - Metabolismen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunoglobulin A - Metabolismen_US
dc.subject.meshKidney - Pathologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNephrotic Syndrome - Complications - Drug Therapy - Pathologyen_US
dc.subject.meshPrednisolone - Therapeutic Useen_US
dc.subject.meshPrednisone - Therapeutic Useen_US
dc.subject.meshRemission Inductionen_US
dc.titleMesangial IgA nephropathy with steroid-responsive nephrotic syndrome: Disappearance of mesangial IgA deposits following steroid-induced remissionen_US
dc.typeArticleen_US
dc.identifier.emailChan, KW:hrmtckw@hku.hken_US
dc.identifier.authorityChan, KW=rp00330en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0272-6386(89)80168-4-
dc.identifier.pmid2816928-
dc.identifier.scopuseid_2-s2.0-0024845568en_US
dc.identifier.volume14en_US
dc.identifier.issue5en_US
dc.identifier.spage361en_US
dc.identifier.epage364en_US
dc.identifier.isiWOS:A1989AY58900004-
dc.publisher.placeUnited Statesen_US

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