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Article: An unusual hepatocellular carcinoma: An ultrastructural and immunohistochemical study

TitleAn unusual hepatocellular carcinoma: An ultrastructural and immunohistochemical study
Authors
Issue Date1988
Citation
Pathology, 1988, v. 20 n. 3, p. 299-302 How to Cite?
AbstractThis paper describes a 50-year-old woman with an unusual malignant tumour of the liver. Poorly differentiated liver cells, tubular structures and spindle cells in abundant intercellular ground substance characterized the tumour. Extremely high serum concentration of alpha-fetoprotein was present. The spindle cells showed strong immunoreactivity against this antigen and vimentin. Both the spindle and epithelial cells showed negative immunoreactivity against desmin, epithelial membrane antigen and keratin. Markers for low molecular cytokeratin (MAK-6, CAM 5.2) were demonstrated in both cell types. Ultrastructurally the neoplastic epithelial cells showed frequent intercellular spaces and well-formed brush borders suggestive of differentiation towards hepatocytes and bile duct epithelium. The immunohistological findings established the epithelial nature of the spindle cells thus distinguishing the tumour from hepatoblastoma.
Persistent Identifierhttp://hdl.handle.net/10722/147808
ISSN
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChan, KWen_US
dc.contributor.authorLeung, CCen_US
dc.date.accessioned2012-05-29T06:09:19Z-
dc.date.available2012-05-29T06:09:19Z-
dc.date.issued1988en_US
dc.identifier.citationPathology, 1988, v. 20 n. 3, p. 299-302en_US
dc.identifier.issn0031-3205en_US
dc.identifier.urihttp://hdl.handle.net/10722/147808-
dc.description.abstractThis paper describes a 50-year-old woman with an unusual malignant tumour of the liver. Poorly differentiated liver cells, tubular structures and spindle cells in abundant intercellular ground substance characterized the tumour. Extremely high serum concentration of alpha-fetoprotein was present. The spindle cells showed strong immunoreactivity against this antigen and vimentin. Both the spindle and epithelial cells showed negative immunoreactivity against desmin, epithelial membrane antigen and keratin. Markers for low molecular cytokeratin (MAK-6, CAM 5.2) were demonstrated in both cell types. Ultrastructurally the neoplastic epithelial cells showed frequent intercellular spaces and well-formed brush borders suggestive of differentiation towards hepatocytes and bile duct epithelium. The immunohistological findings established the epithelial nature of the spindle cells thus distinguishing the tumour from hepatoblastoma.en_US
dc.languageengen_US
dc.relation.ispartofPathologyen_US
dc.subject.meshCarcinoma, Hepatocellular - Analysis - Ultrastructureen_US
dc.subject.meshDesmin - Analysisen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshKeratins - Analysisen_US
dc.subject.meshLiver Neoplasms - Analysis - Pathologyen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshAlpha-Fetoproteins - Blooden_US
dc.titleAn unusual hepatocellular carcinoma: An ultrastructural and immunohistochemical studyen_US
dc.typeArticleen_US
dc.identifier.emailChan, KW:hrmtckw@hku.hken_US
dc.identifier.authorityChan, KW=rp00330en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid2462708en_US
dc.identifier.scopuseid_2-s2.0-0023769515en_US
dc.identifier.volume20en_US
dc.identifier.issue3en_US
dc.identifier.spage299en_US
dc.identifier.epage302en_US
dc.identifier.isiWOS:A1988P430500017-

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