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Article: Lineage specificity of rearrangement and expression of genes encoding the T cell receptor-T3 complex and immunoglobulin heavy chain in leukemia

TitleLineage specificity of rearrangement and expression of genes encoding the T cell receptor-T3 complex and immunoglobulin heavy chain in leukemia
Authors
Issue Date1987
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/leu
Citation
Leukemia, 1987, v. 1 n. 9, p. 644-652 How to Cite?
AbstractIn acute lymphoblastic leukemia (ALL) diagnostic samples and cell lines with unequivocal B cell precursor (common) or T cell precursor immunophenotypes, there is inappropriate or crosslineage IgH or T cell receptor β gene (TCR β) rearrangement in approximately 25% of the cases. The frequency of such rearrangements is lower in mature lymphoid neoplasms and acute myeloblastic leukemia. The most immature B lineage ALL ('null' ALL) has a much lower frequency of TCR gene rearrangement than the common variant of B cell precursor ALL and also has a high frequency of oligoclonal rearrangements of IgH genes. Non-T leukemic cells with inappropriately rearranged TCRβ gene did not necessarily have a rearranged TCRγ gene. Inappropriately rearranged IgH or TCR genes are usually not expressed at the mRNA level, and the gene for the TCR associated protein T3δ is not detectably expressed at the mRNA or protein levels in leukemias classified unambiguously as non-T. Five cases of acute leukemia with ambiguous or mixed lineage immunophenotypes (myeloid + T or myeloid + B) are described. These five had diverse patterns of IgH, TCRβ, and TCRγ rearrangement, and all expressed terminal transferase concomitantly with MY9 (CD33). The T3δ gene was expressed in two cases, which also expressed other T cell markers indicating that coordinated lymphoid lineage programs had been initiated. The implications of these observations for lineage-associated regulation of genes during normal differentiation and leukemogenesis are discussed.
Persistent Identifierhttp://hdl.handle.net/10722/147805
ISSN
2015 Impact Factor: 12.104
2015 SCImago Journal Rankings: 5.142
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorFurley, AJWen_US
dc.contributor.authorChan, LCen_US
dc.contributor.authorMizutani, Sen_US
dc.contributor.authorFord, AMen_US
dc.contributor.authorWeilbaecher, Ken_US
dc.contributor.authorPegram, SMen_US
dc.contributor.authorGreaves, MFen_US
dc.date.accessioned2012-05-29T06:09:19Z-
dc.date.available2012-05-29T06:09:19Z-
dc.date.issued1987en_US
dc.identifier.citationLeukemia, 1987, v. 1 n. 9, p. 644-652en_US
dc.identifier.issn0887-6924en_US
dc.identifier.urihttp://hdl.handle.net/10722/147805-
dc.description.abstractIn acute lymphoblastic leukemia (ALL) diagnostic samples and cell lines with unequivocal B cell precursor (common) or T cell precursor immunophenotypes, there is inappropriate or crosslineage IgH or T cell receptor β gene (TCR β) rearrangement in approximately 25% of the cases. The frequency of such rearrangements is lower in mature lymphoid neoplasms and acute myeloblastic leukemia. The most immature B lineage ALL ('null' ALL) has a much lower frequency of TCR gene rearrangement than the common variant of B cell precursor ALL and also has a high frequency of oligoclonal rearrangements of IgH genes. Non-T leukemic cells with inappropriately rearranged TCRβ gene did not necessarily have a rearranged TCRγ gene. Inappropriately rearranged IgH or TCR genes are usually not expressed at the mRNA level, and the gene for the TCR associated protein T3δ is not detectably expressed at the mRNA or protein levels in leukemias classified unambiguously as non-T. Five cases of acute leukemia with ambiguous or mixed lineage immunophenotypes (myeloid + T or myeloid + B) are described. These five had diverse patterns of IgH, TCRβ, and TCRγ rearrangement, and all expressed terminal transferase concomitantly with MY9 (CD33). The T3δ gene was expressed in two cases, which also expressed other T cell markers indicating that coordinated lymphoid lineage programs had been initiated. The implications of these observations for lineage-associated regulation of genes during normal differentiation and leukemogenesis are discussed.en_US
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/leuen_US
dc.relation.ispartofLeukemiaen_US
dc.subject.meshAdulten_US
dc.subject.meshAntigens, Differentiation, T-Lymphocyte - Analysisen_US
dc.subject.meshB-Lymphocytesen_US
dc.subject.meshFemaleen_US
dc.subject.meshGene Expression Regulationen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunoglobulin Heavy Chains - Geneticsen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshInfant, Newbornen_US
dc.subject.meshLeukemia, Lymphoid - Genetics - Pathologyen_US
dc.subject.meshLeukemia, Myeloid, Acute - Genetics - Pathologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPhenotypeen_US
dc.subject.meshReceptors, Antigen, T-Cell - Geneticsen_US
dc.subject.meshT-Lymphocytesen_US
dc.titleLineage specificity of rearrangement and expression of genes encoding the T cell receptor-T3 complex and immunoglobulin heavy chain in leukemiaen_US
dc.typeArticleen_US
dc.identifier.emailChan, LC:chanlc@hkucc.hku.hken_US
dc.identifier.authorityChan, LC=rp00373en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid3118113-
dc.identifier.scopuseid_2-s2.0-0023639598en_US
dc.identifier.volume1en_US
dc.identifier.issue9en_US
dc.identifier.spage644en_US
dc.identifier.epage652en_US
dc.identifier.isiWOS:A1987K248500003-
dc.publisher.placeUnited Kingdomen_US

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