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Article: Molecular lesion in chronic granulocytic leukemia is highly conserved despite ethnic and geographical variation

TitleMolecular lesion in chronic granulocytic leukemia is highly conserved despite ethnic and geographical variation
Authors
Issue Date1987
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/leu
Citation
Leukemia, 1987, v. 1 n. 6, p. 486-490 How to Cite?
AbstractLeukemic cell DNA from patients with Philadelphia chromosome positive chronic granulocytic leukemia in the United Kingdom, Taiwan, and South Africa and of diverse ethnic origins all have indentifiable molecular rearrangements of the breakpoint cluster region on chromosome 22 band q11 when screened with an appropriate DNA probe. This result reinforces the highly conserved nature of the molecular lesion in chronic granulocytic leukemia and its suitability as a diagnostic marker for the disease. Since the assay can be performed by sample referral on relatively small numbers of nondividing frozen or dead cells, it is ideally suited for large scale epidemiological and clinical studies, particularly in developing countries where karyotyping services are not readily available.
Persistent Identifierhttp://hdl.handle.net/10722/147800
ISSN
2015 Impact Factor: 12.104
2015 SCImago Journal Rankings: 5.142
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChan, LCen_US
dc.contributor.authorChen, PMen_US
dc.contributor.authorPowles, Ren_US
dc.contributor.authorSaragas, Een_US
dc.contributor.authorWiedemann, LMen_US
dc.contributor.authorGroffen, Jen_US
dc.contributor.authorGreaves, MFen_US
dc.date.accessioned2012-05-29T06:09:17Z-
dc.date.available2012-05-29T06:09:17Z-
dc.date.issued1987en_US
dc.identifier.citationLeukemia, 1987, v. 1 n. 6, p. 486-490en_US
dc.identifier.issn0887-6924en_US
dc.identifier.urihttp://hdl.handle.net/10722/147800-
dc.description.abstractLeukemic cell DNA from patients with Philadelphia chromosome positive chronic granulocytic leukemia in the United Kingdom, Taiwan, and South Africa and of diverse ethnic origins all have indentifiable molecular rearrangements of the breakpoint cluster region on chromosome 22 band q11 when screened with an appropriate DNA probe. This result reinforces the highly conserved nature of the molecular lesion in chronic granulocytic leukemia and its suitability as a diagnostic marker for the disease. Since the assay can be performed by sample referral on relatively small numbers of nondividing frozen or dead cells, it is ideally suited for large scale epidemiological and clinical studies, particularly in developing countries where karyotyping services are not readily available.en_US
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/leuen_US
dc.relation.ispartofLeukemiaen_US
dc.subject.meshChromosome Mappingen_US
dc.subject.meshChromosomes, Human, Pair 22en_US
dc.subject.meshDna Restriction Enzymes - Diagnostic Useen_US
dc.subject.meshDna, Neoplasm - Geneticsen_US
dc.subject.meshEthnic Groupsen_US
dc.subject.meshGreat Britainen_US
dc.subject.meshHumansen_US
dc.subject.meshLeukemia, Myeloid - Epidemiology - Geneticsen_US
dc.subject.meshPhiladelphia Chromosomeen_US
dc.subject.meshSouth Africaen_US
dc.subject.meshTaiwanen_US
dc.subject.meshTranslocation, Geneticen_US
dc.titleMolecular lesion in chronic granulocytic leukemia is highly conserved despite ethnic and geographical variationen_US
dc.typeArticleen_US
dc.identifier.emailChan, LC:chanlc@hkucc.hku.hken_US
dc.identifier.authorityChan, LC=rp00373en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid2823024-
dc.identifier.scopuseid_2-s2.0-0023483175en_US
dc.identifier.volume1en_US
dc.identifier.issue6en_US
dc.identifier.spage486en_US
dc.identifier.epage490en_US
dc.identifier.isiWOS:A1987J471800002-
dc.publisher.placeUnited Kingdomen_US

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