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Article: Immunoglobulins (IgG, IgA, IgM, IgE) and complement components (C3, C4) in nephrotic syndrome due to minimal change and other forms of glomerulonephritis, a clue for steroid therapy?

TitleImmunoglobulins (IgG, IgA, IgM, IgE) and complement components (C3, C4) in nephrotic syndrome due to minimal change and other forms of glomerulonephritis, a clue for steroid therapy?
Authors
Issue Date1987
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/NEF
Citation
Nephron, 1987, v. 47 n. 2, p. 125-130 How to Cite?
AbstractSerum IgG, IgA, IgM, IgE, C3 and C4 were measured in 13 patients with minimal change (MC) glomerulonephritis and 10 with the nephrotic syndrome (NS) due to other forms of glomerulonephritis. The tests were repeated in all patients with MC glomerulonephritis when they went into remission. Serum IgG was reduced, IgM, IgE and C3 were raised while serum IgA was within the normal range when the patients were nephrotic. Changes in serum immunoglobulins and complement components were not specific to MC glomerulonephritis and these parameters reverted towards normal when the NS went into remission. Elevated C3 levels probably reflected increased hepatic protein synthesis since C3 correlated significantly with serum cholesterol. There was a tendency for serum IgE concentrations to positively correlate with the total dose of prednisolone required to bring the NS to remission.
Persistent Identifierhttp://hdl.handle.net/10722/147794
ISSN
2004 Impact Factor: 1.462
2006 SCImago Journal Rankings: 0.715
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChan, MKen_US
dc.contributor.authorChan, KWen_US
dc.contributor.authorJones, Ben_US
dc.date.accessioned2012-05-29T06:09:15Z-
dc.date.available2012-05-29T06:09:15Z-
dc.date.issued1987en_US
dc.identifier.citationNephron, 1987, v. 47 n. 2, p. 125-130en_US
dc.identifier.issn0028-2766en_US
dc.identifier.urihttp://hdl.handle.net/10722/147794-
dc.description.abstractSerum IgG, IgA, IgM, IgE, C3 and C4 were measured in 13 patients with minimal change (MC) glomerulonephritis and 10 with the nephrotic syndrome (NS) due to other forms of glomerulonephritis. The tests were repeated in all patients with MC glomerulonephritis when they went into remission. Serum IgG was reduced, IgM, IgE and C3 were raised while serum IgA was within the normal range when the patients were nephrotic. Changes in serum immunoglobulins and complement components were not specific to MC glomerulonephritis and these parameters reverted towards normal when the NS went into remission. Elevated C3 levels probably reflected increased hepatic protein synthesis since C3 correlated significantly with serum cholesterol. There was a tendency for serum IgE concentrations to positively correlate with the total dose of prednisolone required to bring the NS to remission.en_US
dc.languageengen_US
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/NEFen_US
dc.relation.ispartofNephronen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshChilden_US
dc.subject.meshCholesterol - Blooden_US
dc.subject.meshComplement System Proteins - Analysisen_US
dc.subject.meshFemaleen_US
dc.subject.meshGlomerulonephritis - Complications - Drug Therapyen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunoglobulins - Analysisen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNephrosis, Lipoid - Drug Therapy - Immunologyen_US
dc.subject.meshNephrotic Syndrome - Drug Therapy - Etiology - Immunologyen_US
dc.subject.meshPrednisolone - Therapeutic Useen_US
dc.titleImmunoglobulins (IgG, IgA, IgM, IgE) and complement components (C3, C4) in nephrotic syndrome due to minimal change and other forms of glomerulonephritis, a clue for steroid therapy?en_US
dc.typeArticleen_US
dc.identifier.emailChan, KW:hrmtckw@hku.hken_US
dc.identifier.authorityChan, KW=rp00330en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid3696317-
dc.identifier.scopuseid_2-s2.0-0023233225en_US
dc.identifier.volume47en_US
dc.identifier.issue2en_US
dc.identifier.spage125en_US
dc.identifier.epage130en_US
dc.identifier.isiWOS:A1987J987800009-
dc.publisher.placeSwitzerlanden_US

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