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Article: Adult Fanconi syndrome in κ light chain myeloma

TitleAdult Fanconi syndrome in κ light chain myeloma
Authors
Issue Date1987
Citation
Archives Of Pathology And Laboratory Medicine, 1987, v. 111 n. 2, p. 139-142 How to Cite?
AbstractDistinctive morphological features in both the marrow infiltrate and the kidney were seen in a 52-year-old woman with κ light chain-producing plasma cell myeloma, diagnosed on the basis of multiple osteolytic lesions, the presence of atypical plasma cells in the bone marrow, and monoclonal immunoglobulin production as demonstrated by immunoperoxidase staining on marrow sections. Large focal collections of histiocytes in the bone marrow and the renal proximal tubular epithelium had abundant glassy cytoplasm. Characteristic crystalline inclusions were seen ultrastructurally in both types of cells. It is believed that these crystalline deposits are lysosomal inclusions composed of altered κ light chains taken up by these cells. The renal changes were entirely different from those of myeloma kidneys and were associated with proximal tubular dysfunction of adult Fanconi syndrome without distal tubule abnormality.
Persistent Identifierhttp://hdl.handle.net/10722/147789
ISSN
2015 Impact Factor: 2.631
2015 SCImago Journal Rankings: 1.158
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChan, KWen_US
dc.contributor.authorHo, FCSen_US
dc.contributor.authorChan, MKen_US
dc.date.accessioned2012-05-29T06:09:14Z-
dc.date.available2012-05-29T06:09:14Z-
dc.date.issued1987en_US
dc.identifier.citationArchives Of Pathology And Laboratory Medicine, 1987, v. 111 n. 2, p. 139-142en_US
dc.identifier.issn0003-9985en_US
dc.identifier.urihttp://hdl.handle.net/10722/147789-
dc.description.abstractDistinctive morphological features in both the marrow infiltrate and the kidney were seen in a 52-year-old woman with κ light chain-producing plasma cell myeloma, diagnosed on the basis of multiple osteolytic lesions, the presence of atypical plasma cells in the bone marrow, and monoclonal immunoglobulin production as demonstrated by immunoperoxidase staining on marrow sections. Large focal collections of histiocytes in the bone marrow and the renal proximal tubular epithelium had abundant glassy cytoplasm. Characteristic crystalline inclusions were seen ultrastructurally in both types of cells. It is believed that these crystalline deposits are lysosomal inclusions composed of altered κ light chains taken up by these cells. The renal changes were entirely different from those of myeloma kidneys and were associated with proximal tubular dysfunction of adult Fanconi syndrome without distal tubule abnormality.en_US
dc.languageengen_US
dc.relation.ispartofArchives of Pathology and Laboratory Medicineen_US
dc.subject.meshBiopsyen_US
dc.subject.meshBone Marrow - Metabolism - Pathologyen_US
dc.subject.meshFanconi Syndrome - Metabolism - Pathologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHistocytochemistryen_US
dc.subject.meshHumansen_US
dc.subject.meshHypergammaglobulinemia - Metabolism - Pathologyen_US
dc.subject.meshImmunoenzyme Techniquesen_US
dc.subject.meshImmunoglobulin Kappa-Chains - Analysisen_US
dc.subject.meshKidney - Metabolism - Pathologyen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMultiple Myeloma - Metabolism - Pathologyen_US
dc.titleAdult Fanconi syndrome in κ light chain myelomaen_US
dc.typeArticleen_US
dc.identifier.emailChan, KW:hrmtckw@hku.hken_US
dc.identifier.authorityChan, KW=rp00330en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid3101650-
dc.identifier.scopuseid_2-s2.0-0023131954en_US
dc.identifier.volume111en_US
dc.identifier.issue2en_US
dc.identifier.spage139en_US
dc.identifier.epage142en_US
dc.identifier.isiWOS:A1987F807900012-

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