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Article: Rearrangement of immunoglobulin heavy chain genes in human T leukaemic cells shows preferential utilization of the D segment (DQ52) nearest to the J region.

TitleRearrangement of immunoglobulin heavy chain genes in human T leukaemic cells shows preferential utilization of the D segment (DQ52) nearest to the J region.
Authors
Issue Date1986
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/emboj/index.html
Citation
Embo Journal, 1986, v. 5 n. 13, p. 3467-3473 How to Cite?
AbstractThe DNA rearrangements leading to the assembly of genes coding for the immunoglobulin heavy chain (IgH) in B cells and the T cell receptor for antigen in T cells are not completely lineage specific. This probably reflects the use of a common recombinase by IgH and the T cell receptor. This paper describes novel observations on the nature of these cross-lineage rearrangements. A high proportion (though not all) IgH rearrangements in human T leukaemic cells involve the D segment nearest to the J region (DQ52). This same D segment is not involved in B cell IgH rearrangements with one important exception, namely a proportion of B cell leukaemic clones with the most primitive B cell precursor phenotype. These observations have potentially important implications for early lymphoid cell differentiation and in particular support the idea that the 3' D plus J region might lie within a limited window of accessibility of the IgH gene in precursor lymphocytes.
Persistent Identifierhttp://hdl.handle.net/10722/147785
ISSN
2015 Impact Factor: 9.643
2015 SCImago Journal Rankings: 7.450
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMizutani, Sen_US
dc.contributor.authorFord, AMen_US
dc.contributor.authorWiedemann, LMen_US
dc.contributor.authorChan, LCen_US
dc.contributor.authorFurley, AJen_US
dc.contributor.authorGreaves, MFen_US
dc.contributor.authorMolgaard, HVen_US
dc.date.accessioned2012-05-29T06:09:13Z-
dc.date.available2012-05-29T06:09:13Z-
dc.date.issued1986en_US
dc.identifier.citationEmbo Journal, 1986, v. 5 n. 13, p. 3467-3473en_US
dc.identifier.issn0261-4189en_US
dc.identifier.urihttp://hdl.handle.net/10722/147785-
dc.description.abstractThe DNA rearrangements leading to the assembly of genes coding for the immunoglobulin heavy chain (IgH) in B cells and the T cell receptor for antigen in T cells are not completely lineage specific. This probably reflects the use of a common recombinase by IgH and the T cell receptor. This paper describes novel observations on the nature of these cross-lineage rearrangements. A high proportion (though not all) IgH rearrangements in human T leukaemic cells involve the D segment nearest to the J region (DQ52). This same D segment is not involved in B cell IgH rearrangements with one important exception, namely a proportion of B cell leukaemic clones with the most primitive B cell precursor phenotype. These observations have potentially important implications for early lymphoid cell differentiation and in particular support the idea that the 3' D plus J region might lie within a limited window of accessibility of the IgH gene in precursor lymphocytes.en_US
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/emboj/index.htmlen_US
dc.relation.ispartofEMBO Journalen_US
dc.subject.meshDna Restriction Enzymesen_US
dc.subject.meshGenesen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunoglobulin Heavy Chains - Geneticsen_US
dc.subject.meshImmunoglobulin J-Chains - Geneticsen_US
dc.subject.meshLeukemia - Genetics - Immunologyen_US
dc.subject.meshNucleic Acid Hybridizationen_US
dc.subject.meshT-Lymphocytes - Immunologyen_US
dc.titleRearrangement of immunoglobulin heavy chain genes in human T leukaemic cells shows preferential utilization of the D segment (DQ52) nearest to the J region.en_US
dc.typeArticleen_US
dc.identifier.emailChan, LC:chanlc@hkucc.hku.hken_US
dc.identifier.authorityChan, LC=rp00373en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid3030728-
dc.identifier.scopuseid_2-s2.0-0023054155en_US
dc.identifier.volume5en_US
dc.identifier.issue13en_US
dc.identifier.spage3467en_US
dc.identifier.epage3473en_US
dc.identifier.isiWOS:A1986F415400009-
dc.publisher.placeUnited Kingdomen_US

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