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Article: Nudeotide sequence of the chicken 5-aminolevulinate synthase gene

TitleNudeotide sequence of the chicken 5-aminolevulinate synthase gene
Authors
Issue Date1986
PublisherOxford University Press. The Journal's web site is located at http://nar.oxfordjournals.org/
Citation
Nucleic Acids Research, 1986, v. 14 n. 3, p. 1379-1391 How to Cite?
Abstract5-Aminolevul inate synthase, the first and rate-controlling enzyme of heme biosynthesis, is regulated in the liver by the end-product heme. To study this negative control mechanism, we have isolated the chicken gene for ALA-synthase and determined the nucleotide sequence. The structural gene is 6.9 kb long and contains 10 exons. The transcriptional start site for ALA-synthase was determined by primer extension analysis. A fragment of 291 b p from the 5′ flanking region including 34 b p of the first exon shows promoter activity when introduced upstream of a chicken hi stone H2B gene and injected into the nuclei of Xenopus laevis oocytes. © 1986 IRL Press Limited.
Persistent Identifierhttp://hdl.handle.net/10722/147784
ISSN
2015 Impact Factor: 9.202
2015 SCImago Journal Rankings: 7.458
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMaguire, DJen_US
dc.contributor.authorDay, ARen_US
dc.contributor.authorBorthwick, IAen_US
dc.contributor.authorSrivastava, Gen_US
dc.contributor.authorWigley, PLen_US
dc.contributor.authorMay, BKen_US
dc.contributor.authorElliott, WHen_US
dc.date.accessioned2012-05-29T06:09:12Z-
dc.date.available2012-05-29T06:09:12Z-
dc.date.issued1986en_US
dc.identifier.citationNucleic Acids Research, 1986, v. 14 n. 3, p. 1379-1391en_US
dc.identifier.issn0305-1048en_US
dc.identifier.urihttp://hdl.handle.net/10722/147784-
dc.description.abstract5-Aminolevul inate synthase, the first and rate-controlling enzyme of heme biosynthesis, is regulated in the liver by the end-product heme. To study this negative control mechanism, we have isolated the chicken gene for ALA-synthase and determined the nucleotide sequence. The structural gene is 6.9 kb long and contains 10 exons. The transcriptional start site for ALA-synthase was determined by primer extension analysis. A fragment of 291 b p from the 5′ flanking region including 34 b p of the first exon shows promoter activity when introduced upstream of a chicken hi stone H2B gene and injected into the nuclei of Xenopus laevis oocytes. © 1986 IRL Press Limited.en_US
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://nar.oxfordjournals.org/en_US
dc.relation.ispartofNucleic Acids Researchen_US
dc.titleNudeotide sequence of the chicken 5-aminolevulinate synthase geneen_US
dc.typeArticleen_US
dc.identifier.emailSrivastava, G:gopesh@pathology.hku.hken_US
dc.identifier.authoritySrivastava, G=rp00365en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1093/nar/14.3.1379en_US
dc.identifier.scopuseid_2-s2.0-0023046581en_US
dc.identifier.volume14en_US
dc.identifier.issue3en_US
dc.identifier.spage1379en_US
dc.identifier.epage1391en_US
dc.identifier.isiWOS:A1986A079500019-
dc.publisher.placeUnited Kingdomen_US

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