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Article: False-negative errors in fine-needle aspiration biopsy of dominant thyroid nodules: A prospective follow-up study

TitleFalse-negative errors in fine-needle aspiration biopsy of dominant thyroid nodules: A prospective follow-up study
Authors
Issue Date1986
PublisherSpringer New York LLC. The Journal's web site is located at http://link.springer.de/link/service/journals/00268/
Citation
World Journal Of Surgery, 1986, v. 10 n. 4, p. 623-630 How to Cite?
AbstractReluctance to adopt fine-needle aspiration (FNA) of dominant thyroid nodules stems largely from fear of overlooking a malignancy in a nodule diagnosed as benign on FNA (false-negative error). Published error rates have been derived from surgical series without regard to the outcome of those who were followed without operation. In order to ascertain the overall false-negative error rate, the authors conducted a prospective study in 600 patients who underwent FNA. Among the 482 study patients who had a benign FNA diagnosis or inadequate specimens, 117 underwent surgery because of the concurrent large-needle biopsy result or a clinical suspicion of malignancy. Eight false-negative errors were identified in this group, 5 of which were detected by large-needle biopsy. Among the remaining 365 patients who were followed for an average of 2 1/2 years, 2 patients were found to have well-differentiated carcinomas in recurrent cysts. The overall false-negative error rate of FNA alone in all 482 patients was 2.1%. This was reduced to 1.0% by the use of concurrent large-needle biopsy. Properly applied, FNA can reduce unnecessary surgery among patients with clinically benign nodules without incurring an unacceptably high false-negative error rate. Furthermore, this error rate may be reduced substantially by combining large-needle biopsy with FNA and by close follow-up with surgery performed later in patients who manifest clinical features suggestive of malignancy.
Persistent Identifierhttp://hdl.handle.net/10722/147783
ISSN
2015 Impact Factor: 2.523
2015 SCImago Journal Rankings: 1.375
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorBoey, Jen_US
dc.contributor.authorHsu, Cen_US
dc.contributor.authorCollins, RJen_US
dc.date.accessioned2012-05-29T06:09:12Z-
dc.date.available2012-05-29T06:09:12Z-
dc.date.issued1986en_US
dc.identifier.citationWorld Journal Of Surgery, 1986, v. 10 n. 4, p. 623-630en_US
dc.identifier.issn0364-2313en_US
dc.identifier.urihttp://hdl.handle.net/10722/147783-
dc.description.abstractReluctance to adopt fine-needle aspiration (FNA) of dominant thyroid nodules stems largely from fear of overlooking a malignancy in a nodule diagnosed as benign on FNA (false-negative error). Published error rates have been derived from surgical series without regard to the outcome of those who were followed without operation. In order to ascertain the overall false-negative error rate, the authors conducted a prospective study in 600 patients who underwent FNA. Among the 482 study patients who had a benign FNA diagnosis or inadequate specimens, 117 underwent surgery because of the concurrent large-needle biopsy result or a clinical suspicion of malignancy. Eight false-negative errors were identified in this group, 5 of which were detected by large-needle biopsy. Among the remaining 365 patients who were followed for an average of 2 1/2 years, 2 patients were found to have well-differentiated carcinomas in recurrent cysts. The overall false-negative error rate of FNA alone in all 482 patients was 2.1%. This was reduced to 1.0% by the use of concurrent large-needle biopsy. Properly applied, FNA can reduce unnecessary surgery among patients with clinically benign nodules without incurring an unacceptably high false-negative error rate. Furthermore, this error rate may be reduced substantially by combining large-needle biopsy with FNA and by close follow-up with surgery performed later in patients who manifest clinical features suggestive of malignancy.en_US
dc.languageengen_US
dc.publisherSpringer New York LLC. The Journal's web site is located at http://link.springer.de/link/service/journals/00268/en_US
dc.relation.ispartofWorld Journal of Surgeryen_US
dc.subject.meshAdulten_US
dc.subject.meshBiopsy, Needleen_US
dc.subject.meshFalse Negative Reactionsen_US
dc.subject.meshFemaleen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshThyroid Diseases - Diagnosisen_US
dc.subject.meshThyroid Neoplasms - Diagnosis - Surgeryen_US
dc.titleFalse-negative errors in fine-needle aspiration biopsy of dominant thyroid nodules: A prospective follow-up studyen_US
dc.typeArticleen_US
dc.identifier.emailCollins, RJ:rcollins@hkucc.hku.hken_US
dc.identifier.authorityCollins, RJ=rp00251en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid3751089en_US
dc.identifier.scopuseid_2-s2.0-0023039515en_US
dc.identifier.volume10en_US
dc.identifier.issue4en_US
dc.identifier.spage623en_US
dc.identifier.epage630en_US
dc.identifier.isiWOS:A1986D347000012-
dc.publisher.placeUnited Statesen_US

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