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Article: Is spontaneous mutation the major 'cause' of childhood acute lymphoblastic leukaemia? The paucity of evidence for environmental and genetic factors in acute lymphoblastic leukaemia

TitleIs spontaneous mutation the major 'cause' of childhood acute lymphoblastic leukaemia? The paucity of evidence for environmental and genetic factors in acute lymphoblastic leukaemia
Authors
Issue Date1986
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJH
Citation
British Journal Of Haematology, 1986, v. 64 n. 1, p. 1-13 How to Cite?
AbstractAcute lymphoblastic leukemia (ALL) in children has an annual incidence rate of around two to three cases per 10 5 age-matched population in Europe and the U.S.A. Although it is rare compared with the common cancers of adults, ALL is the major paediatric cancer in developed societies. Despite substantial advances in the treatment of ALL and understanding of its biology the aetiology of this disease remains enigmatic. Doubtless the very rarity of childhood leukaemia has been a major impediment to epidemiological studies which might provide clues to causality. Nevertheless, a substantial number of environmental, genetic (inherited) or immunological factors are reported to be associated with the occurrence of ALL. Most of these correlates are, however, rather weak, controversial or as yet unsubstantiated. A few that are more striking and potentially important are discussed.
Persistent Identifierhttp://hdl.handle.net/10722/147777
ISSN
2015 Impact Factor: 5.401
2015 SCImago Journal Rankings: 2.313
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorGreaves, MFen_US
dc.contributor.authorChan, LCen_US
dc.date.accessioned2012-05-29T06:09:10Z-
dc.date.available2012-05-29T06:09:10Z-
dc.date.issued1986en_US
dc.identifier.citationBritish Journal Of Haematology, 1986, v. 64 n. 1, p. 1-13en_US
dc.identifier.issn0007-1048en_US
dc.identifier.urihttp://hdl.handle.net/10722/147777-
dc.description.abstractAcute lymphoblastic leukemia (ALL) in children has an annual incidence rate of around two to three cases per 10 5 age-matched population in Europe and the U.S.A. Although it is rare compared with the common cancers of adults, ALL is the major paediatric cancer in developed societies. Despite substantial advances in the treatment of ALL and understanding of its biology the aetiology of this disease remains enigmatic. Doubtless the very rarity of childhood leukaemia has been a major impediment to epidemiological studies which might provide clues to causality. Nevertheless, a substantial number of environmental, genetic (inherited) or immunological factors are reported to be associated with the occurrence of ALL. Most of these correlates are, however, rather weak, controversial or as yet unsubstantiated. A few that are more striking and potentially important are discussed.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJHen_US
dc.relation.ispartofBritish Journal of Haematologyen_US
dc.subject.meshAcute Diseaseen_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshEnvironmenten_US
dc.subject.meshHumansen_US
dc.subject.meshLeukemia, Lymphoid - Etiology - Geneticsen_US
dc.subject.meshLeukemia, Radiation-Induceden_US
dc.subject.meshMutationen_US
dc.subject.meshRisken_US
dc.subject.meshSocioeconomic Factorsen_US
dc.titleIs spontaneous mutation the major 'cause' of childhood acute lymphoblastic leukaemia? The paucity of evidence for environmental and genetic factors in acute lymphoblastic leukaemiaen_US
dc.typeArticleen_US
dc.identifier.emailChan, LC:chanlc@hkucc.hku.hken_US
dc.identifier.authorityChan, LC=rp00373en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid3530312-
dc.identifier.scopuseid_2-s2.0-0022885314en_US
dc.identifier.volume64en_US
dc.identifier.issue1en_US
dc.identifier.spage1en_US
dc.identifier.epage13en_US
dc.identifier.isiWOS:A1986D906100001-
dc.publisher.placeUnited Kingdomen_US

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