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- Scopus: eid_2-s2.0-0022622380
- PMID: 3002526
- WOS: WOS:A1986AZK8500045
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Article: Clonal rearrangement and expression of the T cell receptor β gene and involvement of the breakpoint cluster region in blast crisis of CGL
Title | Clonal rearrangement and expression of the T cell receptor β gene and involvement of the breakpoint cluster region in blast crisis of CGL |
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Authors | |
Issue Date | 1986 |
Publisher | American Society of Hematology. The Journal's web site is located at http://bloodjournal.hematologylibrary.org/ |
Citation | Blood, 1986, v. 67 n. 2, p. 533-536 How to Cite? |
Abstract | A case of lymphoid blast crisis of Ph1-positive CGL is described in which the blast cells had an immature T cell phenotype, clonal rearrangement and expression of the T cell receptor β gene, and a rearrangement of the breakpoint cluster region (bcr) on chromosome 22. This case therefore provides definite evidence for transformation involving a common myeloid-T lineage progenitor, penetrance of the Ph1 molecular alteration into the T cell lineage, and clonal selection in blast crisis at the level of a committed T lineage precursor. |
Persistent Identifier | http://hdl.handle.net/10722/147773 |
ISSN | 2023 Impact Factor: 21.0 2023 SCImago Journal Rankings: 5.272 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Chan, LC | en_US |
dc.contributor.author | Furley, AJ | en_US |
dc.contributor.author | Ford, AM | en_US |
dc.date.accessioned | 2012-05-29T06:09:09Z | - |
dc.date.available | 2012-05-29T06:09:09Z | - |
dc.date.issued | 1986 | en_US |
dc.identifier.citation | Blood, 1986, v. 67 n. 2, p. 533-536 | en_US |
dc.identifier.issn | 0006-4971 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/147773 | - |
dc.description.abstract | A case of lymphoid blast crisis of Ph1-positive CGL is described in which the blast cells had an immature T cell phenotype, clonal rearrangement and expression of the T cell receptor β gene, and a rearrangement of the breakpoint cluster region (bcr) on chromosome 22. This case therefore provides definite evidence for transformation involving a common myeloid-T lineage progenitor, penetrance of the Ph1 molecular alteration into the T cell lineage, and clonal selection in blast crisis at the level of a committed T lineage precursor. | en_US |
dc.language | eng | en_US |
dc.publisher | American Society of Hematology. The Journal's web site is located at http://bloodjournal.hematologylibrary.org/ | en_US |
dc.relation.ispartof | Blood | en_US |
dc.subject.mesh | Chromosome Mapping | en_US |
dc.subject.mesh | Dna Restriction Enzymes - Diagnostic Use | en_US |
dc.subject.mesh | Genes | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Leukemia, Myeloid - Genetics | en_US |
dc.subject.mesh | Macromolecular Substances | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Middle Aged | en_US |
dc.subject.mesh | Nucleic Acid Hybridization | en_US |
dc.subject.mesh | Philadelphia Chromosome | en_US |
dc.subject.mesh | Receptors, Antigen, T-Cell - Genetics - Immunology | en_US |
dc.subject.mesh | Recombination, Genetic | en_US |
dc.subject.mesh | Translocation, Genetic | en_US |
dc.title | Clonal rearrangement and expression of the T cell receptor β gene and involvement of the breakpoint cluster region in blast crisis of CGL | en_US |
dc.type | Article | en_US |
dc.identifier.email | Chan, LC:chanlc@hkucc.hku.hk | en_US |
dc.identifier.authority | Chan, LC=rp00373 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.pmid | 3002526 | - |
dc.identifier.scopus | eid_2-s2.0-0022622380 | en_US |
dc.identifier.volume | 67 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.spage | 533 | en_US |
dc.identifier.epage | 536 | en_US |
dc.identifier.isi | WOS:A1986AZK8500045 | - |
dc.publisher.place | United States | en_US |
dc.identifier.issnl | 0006-4971 | - |