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Article: Clonal rearrangement and expression of the T cell receptor β gene and involvement of the breakpoint cluster region in blast crisis of CGL

TitleClonal rearrangement and expression of the T cell receptor β gene and involvement of the breakpoint cluster region in blast crisis of CGL
Authors
Issue Date1986
PublisherAmerican Society of Hematology. The Journal's web site is located at http://bloodjournal.hematologylibrary.org/
Citation
Blood, 1986, v. 67 n. 2, p. 533-536 How to Cite?
AbstractA case of lymphoid blast crisis of Ph1-positive CGL is described in which the blast cells had an immature T cell phenotype, clonal rearrangement and expression of the T cell receptor β gene, and a rearrangement of the breakpoint cluster region (bcr) on chromosome 22. This case therefore provides definite evidence for transformation involving a common myeloid-T lineage progenitor, penetrance of the Ph1 molecular alteration into the T cell lineage, and clonal selection in blast crisis at the level of a committed T lineage precursor.
Persistent Identifierhttp://hdl.handle.net/10722/147773
ISSN
2015 Impact Factor: 11.841
2015 SCImago Journal Rankings: 6.395
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChan, LCen_US
dc.contributor.authorFurley, AJen_US
dc.contributor.authorFord, AMen_US
dc.date.accessioned2012-05-29T06:09:09Z-
dc.date.available2012-05-29T06:09:09Z-
dc.date.issued1986en_US
dc.identifier.citationBlood, 1986, v. 67 n. 2, p. 533-536en_US
dc.identifier.issn0006-4971en_US
dc.identifier.urihttp://hdl.handle.net/10722/147773-
dc.description.abstractA case of lymphoid blast crisis of Ph1-positive CGL is described in which the blast cells had an immature T cell phenotype, clonal rearrangement and expression of the T cell receptor β gene, and a rearrangement of the breakpoint cluster region (bcr) on chromosome 22. This case therefore provides definite evidence for transformation involving a common myeloid-T lineage progenitor, penetrance of the Ph1 molecular alteration into the T cell lineage, and clonal selection in blast crisis at the level of a committed T lineage precursor.en_US
dc.languageengen_US
dc.publisherAmerican Society of Hematology. The Journal's web site is located at http://bloodjournal.hematologylibrary.org/en_US
dc.relation.ispartofBlooden_US
dc.subject.meshChromosome Mappingen_US
dc.subject.meshDna Restriction Enzymes - Diagnostic Useen_US
dc.subject.meshGenesen_US
dc.subject.meshHumansen_US
dc.subject.meshLeukemia, Myeloid - Geneticsen_US
dc.subject.meshMacromolecular Substancesen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNucleic Acid Hybridizationen_US
dc.subject.meshPhiladelphia Chromosomeen_US
dc.subject.meshReceptors, Antigen, T-Cell - Genetics - Immunologyen_US
dc.subject.meshRecombination, Geneticen_US
dc.subject.meshTranslocation, Geneticen_US
dc.titleClonal rearrangement and expression of the T cell receptor β gene and involvement of the breakpoint cluster region in blast crisis of CGLen_US
dc.typeArticleen_US
dc.identifier.emailChan, LC:chanlc@hkucc.hku.hken_US
dc.identifier.authorityChan, LC=rp00373en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid3002526-
dc.identifier.scopuseid_2-s2.0-0022622380en_US
dc.identifier.volume67en_US
dc.identifier.issue2en_US
dc.identifier.spage533en_US
dc.identifier.epage536en_US
dc.identifier.isiWOS:A1986AZK8500045-
dc.publisher.placeUnited Statesen_US

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