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Article: Mast cell leukaemia: Evidence for bone marrow origin of the pathological clone

TitleMast cell leukaemia: Evidence for bone marrow origin of the pathological clone
Authors
Issue Date1986
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJH
Citation
British Journal Of Haematology, 1986, v. 64 n. 2, p. 397-406 How to Cite?
AbstractA 57-year-old female patient, admitted for an acute abdominal syndrome, was found to have an extensive proliferation of mast cells both in the peripheral blood and the bone marrow. Cytochemical studies confirmed the mast cell characteristics of the pathological cell population, while the immunophenotype strongly suggested a bone marrow origin of this malignancy. The course of the disease was not affected by antiproliferative treatment and the patient, after progressive general deterioration, died of intractable haemorrhage. On both clinical and haematological criteria it seems possible to distinguish this rare case of primary mast leukaemia from the more common form of tissue mastocytosis with secondary leukaemia.
Persistent Identifierhttp://hdl.handle.net/10722/147770
ISSN
2015 Impact Factor: 5.401
2015 SCImago Journal Rankings: 2.313
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorDalton, Ren_US
dc.contributor.authorChan, Len_US
dc.contributor.authorBatten, Een_US
dc.contributor.authorEridani, Sen_US
dc.date.accessioned2012-05-29T06:09:08Z-
dc.date.available2012-05-29T06:09:08Z-
dc.date.issued1986en_US
dc.identifier.citationBritish Journal Of Haematology, 1986, v. 64 n. 2, p. 397-406en_US
dc.identifier.issn0007-1048en_US
dc.identifier.urihttp://hdl.handle.net/10722/147770-
dc.description.abstractA 57-year-old female patient, admitted for an acute abdominal syndrome, was found to have an extensive proliferation of mast cells both in the peripheral blood and the bone marrow. Cytochemical studies confirmed the mast cell characteristics of the pathological cell population, while the immunophenotype strongly suggested a bone marrow origin of this malignancy. The course of the disease was not affected by antiproliferative treatment and the patient, after progressive general deterioration, died of intractable haemorrhage. On both clinical and haematological criteria it seems possible to distinguish this rare case of primary mast leukaemia from the more common form of tissue mastocytosis with secondary leukaemia.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJHen_US
dc.relation.ispartofBritish Journal of Haematologyen_US
dc.subject.meshBone Marrow - Pathology - Ultrastructureen_US
dc.subject.meshCytoplasmic Granules - Ultrastructureen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshLeukemia, Mast-Cell - Pathologyen_US
dc.subject.meshMast Cells - Pathology - Ultrastructureen_US
dc.subject.meshMicroscopy, Electronen_US
dc.subject.meshMiddle Ageden_US
dc.titleMast cell leukaemia: Evidence for bone marrow origin of the pathological cloneen_US
dc.typeArticleen_US
dc.identifier.emailChan, L:chanlc@hkucc.hku.hken_US
dc.identifier.authorityChan, L=rp00373en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid3096368-
dc.identifier.scopuseid_2-s2.0-0022485244en_US
dc.identifier.volume64en_US
dc.identifier.issue2en_US
dc.identifier.spage397en_US
dc.identifier.epage406en_US
dc.identifier.isiWOS:A1986E419900021-
dc.publisher.placeUnited Kingdomen_US

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