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Article: Acute biphenotypic leukaemia (myeloid and null-ALL type) supervening in a myelodysplastic syndrome

TitleAcute biphenotypic leukaemia (myeloid and null-ALL type) supervening in a myelodysplastic syndrome
Authors
Issue Date1985
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJH
Citation
British Journal Of Haematology, 1985, v. 61 n. 3, p. 525-529 How to Cite?
AbstractAn acute leukaemia was seen in a 72-year-old patient with a myelodysplastic syndrome (MDS) of 14 months duration, who had been treated only with steroids. The morphological appearance of the blast cells suggested a poorly differentiated cell type. Surface marker analysis, including double staining studies, showed the coexistence of a population of null acute lymphoblastic leukaemia (ALL) blast cells together with acute myeloid leukaemia type cells. No chromosomal alterations were detected. The change from a chronic MDS to an acute leukaemia of mixed (myeloid and null ALL) type suggests either transformation of a pre-existing abnormal clone or de novo appearance of two separate leukaemic clones.
Persistent Identifierhttp://hdl.handle.net/10722/147768
ISSN
2015 Impact Factor: 5.401
2015 SCImago Journal Rankings: 2.313
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorEridani, Sen_US
dc.contributor.authorChan, LCen_US
dc.contributor.authorHalil, Oen_US
dc.contributor.authorPearson, TCen_US
dc.date.accessioned2012-05-29T06:09:08Z-
dc.date.available2012-05-29T06:09:08Z-
dc.date.issued1985en_US
dc.identifier.citationBritish Journal Of Haematology, 1985, v. 61 n. 3, p. 525-529en_US
dc.identifier.issn0007-1048en_US
dc.identifier.urihttp://hdl.handle.net/10722/147768-
dc.description.abstractAn acute leukaemia was seen in a 72-year-old patient with a myelodysplastic syndrome (MDS) of 14 months duration, who had been treated only with steroids. The morphological appearance of the blast cells suggested a poorly differentiated cell type. Surface marker analysis, including double staining studies, showed the coexistence of a population of null acute lymphoblastic leukaemia (ALL) blast cells together with acute myeloid leukaemia type cells. No chromosomal alterations were detected. The change from a chronic MDS to an acute leukaemia of mixed (myeloid and null ALL) type suggests either transformation of a pre-existing abnormal clone or de novo appearance of two separate leukaemic clones.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJHen_US
dc.relation.ispartofBritish Journal of Haematologyen_US
dc.subject.meshAgeden_US
dc.subject.meshBone Marrow - Pathologyen_US
dc.subject.meshHematopoietic Stem Cells - Pathologyen_US
dc.subject.meshHumansen_US
dc.subject.meshLeukemia, Lymphoid - Etiology - Pathologyen_US
dc.subject.meshLeukemia, Myeloid, Acute - Etiology - Pathologyen_US
dc.subject.meshLymphocytes, Nullen_US
dc.subject.meshMaleen_US
dc.subject.meshMyelodysplastic Syndromes - Complications - Pathologyen_US
dc.subject.meshPhenotypeen_US
dc.titleAcute biphenotypic leukaemia (myeloid and null-ALL type) supervening in a myelodysplastic syndromeen_US
dc.typeArticleen_US
dc.identifier.emailChan, LC:chanlc@hkucc.hku.hken_US
dc.identifier.authorityChan, LC=rp00373en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid3864486en_US
dc.identifier.scopuseid_2-s2.0-0022359468en_US
dc.identifier.volume61en_US
dc.identifier.issue3en_US
dc.identifier.spage525en_US
dc.identifier.epage529en_US
dc.identifier.isiWOS:A1985AUP8300017-
dc.publisher.placeUnited Kingdomen_US

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