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Article: Contribution of immunophenotype to the classification and differential diagnosis of acute leukaemia

TitleContribution of immunophenotype to the classification and differential diagnosis of acute leukaemia
Authors
Issue Date1985
PublisherThe Lancet Publishing Group. The Journal's web site is located at http://www.elsevier.com/locate/lancet
Citation
Lancet, 1985, v. 1 n. 8427, p. 475-479 How to Cite?
AbstractThe diagnostic value of a panel of monoclonal antibodies was assessed in 100 consecutive patients with acute leukaemia. Ninety-seven patients were clearly phenotyped. Clinical and haematological feedback showed that the immunological data made a critical contribution to the final haematological diagnosis in 19 patients and provided useful confirmatory data in another 78. Immunophenotype also provided the basis for a subset classification of known prognostic relevance to acute lymphoblastic leukaemia (ALL). Immunophenotype and haematological findings conflicted in 2 cases, and 3 cases were unclassifiable with the antibody panel. In these difficult cases leukaemic-cell DNA was investigated for immunoglobulin gene arrangement. Immunophenotyping with selective probes may be used in conjunction with other laboratory analyses (eg, karyotyping) in the routine investigation of patients with acute leukaemia.
Persistent Identifierhttp://hdl.handle.net/10722/147760
ISSN
2015 Impact Factor: 44.002
2015 SCImago Journal Rankings: 14.638
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChan, LCen_US
dc.contributor.authorPegram, SMen_US
dc.contributor.authorGreaves, MFen_US
dc.date.accessioned2012-05-29T06:09:06Z-
dc.date.available2012-05-29T06:09:06Z-
dc.date.issued1985en_US
dc.identifier.citationLancet, 1985, v. 1 n. 8427, p. 475-479en_US
dc.identifier.issn0140-6736en_US
dc.identifier.urihttp://hdl.handle.net/10722/147760-
dc.description.abstractThe diagnostic value of a panel of monoclonal antibodies was assessed in 100 consecutive patients with acute leukaemia. Ninety-seven patients were clearly phenotyped. Clinical and haematological feedback showed that the immunological data made a critical contribution to the final haematological diagnosis in 19 patients and provided useful confirmatory data in another 78. Immunophenotype also provided the basis for a subset classification of known prognostic relevance to acute lymphoblastic leukaemia (ALL). Immunophenotype and haematological findings conflicted in 2 cases, and 3 cases were unclassifiable with the antibody panel. In these difficult cases leukaemic-cell DNA was investigated for immunoglobulin gene arrangement. Immunophenotyping with selective probes may be used in conjunction with other laboratory analyses (eg, karyotyping) in the routine investigation of patients with acute leukaemia.en_US
dc.languageengen_US
dc.publisherThe Lancet Publishing Group. The Journal's web site is located at http://www.elsevier.com/locate/lanceten_US
dc.relation.ispartofLanceten_US
dc.subject.meshAcute Diseaseen_US
dc.subject.meshAgeden_US
dc.subject.meshAntibodies, Monoclonal - Diagnostic Useen_US
dc.subject.meshChilden_US
dc.subject.meshDna, Neoplasm - Geneticsen_US
dc.subject.meshDiagnosis, Differentialen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshLeukemia, Lymphoid - Diagnosisen_US
dc.subject.meshLeukemia, Myeloid - Diagnosisen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPhenotypeen_US
dc.subject.meshReceptors, Antigen, B-Cell - Geneticsen_US
dc.titleContribution of immunophenotype to the classification and differential diagnosis of acute leukaemiaen_US
dc.typeArticleen_US
dc.identifier.emailChan, LC:chanlc@hkucc.hku.hken_US
dc.identifier.authorityChan, LC=rp00373en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid2857851-
dc.identifier.scopuseid_2-s2.0-0021907434en_US
dc.identifier.volume1en_US
dc.identifier.issue8427en_US
dc.identifier.spage475en_US
dc.identifier.epage479en_US
dc.identifier.isiWOS:A1985ACJ9600001-
dc.publisher.placeUnited Kingdomen_US

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