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Article: Peripheral glomerular capillary wall lesions in IgA nephropathy and their implications

TitlePeripheral glomerular capillary wall lesions in IgA nephropathy and their implications
Authors
Issue Date1984
PublisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/00313025.asp
Citation
Pathology, 1984, v. 16 n. 3, p. 324-330 How to Cite?
AbstractPeripheral glomerular capillary walls were studied in 26 cases of IgA nephropathy by means of the transmission electron microscope. Ultrastructural abnormalities were identified in 11 cases (42%). Abnormalities of the glomerular basement membrane (GBM) were the most frequent change which consisted of localized thinning, lamination, irregular thickening, disruption, membranolysis and aneurysmal dilatation of the GBM. Subendothelial electron dense deposits were seen. Necrosis and detachment of the podocytes from the GBM were also encountered. The changes were correlated with the clinical findings at the time of diagnosis which showed a significant correlation of these peripheral glomerular capillary wall lesions with proteinuria. With light microscopy, crescents were significantly more frequently seen in the cases showing the ultrastructural capillary wall abnormalities than those without. This observation suggested that local peripheral glomerular capillary wall damage was an important factor in the pathogenesis of the extracapillary lesions in IgA nephropathy.
Persistent Identifierhttp://hdl.handle.net/10722/147751
ISSN
2015 Impact Factor: 2.968
2015 SCImago Journal Rankings: 1.049
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorNg, WLen_US
dc.contributor.authorChan, KWen_US
dc.contributor.authorYeung, CKen_US
dc.contributor.authorKwan, Sen_US
dc.date.accessioned2012-05-29T06:09:03Z-
dc.date.available2012-05-29T06:09:03Z-
dc.date.issued1984en_US
dc.identifier.citationPathology, 1984, v. 16 n. 3, p. 324-330en_US
dc.identifier.issn0031-3025en_US
dc.identifier.urihttp://hdl.handle.net/10722/147751-
dc.description.abstractPeripheral glomerular capillary walls were studied in 26 cases of IgA nephropathy by means of the transmission electron microscope. Ultrastructural abnormalities were identified in 11 cases (42%). Abnormalities of the glomerular basement membrane (GBM) were the most frequent change which consisted of localized thinning, lamination, irregular thickening, disruption, membranolysis and aneurysmal dilatation of the GBM. Subendothelial electron dense deposits were seen. Necrosis and detachment of the podocytes from the GBM were also encountered. The changes were correlated with the clinical findings at the time of diagnosis which showed a significant correlation of these peripheral glomerular capillary wall lesions with proteinuria. With light microscopy, crescents were significantly more frequently seen in the cases showing the ultrastructural capillary wall abnormalities than those without. This observation suggested that local peripheral glomerular capillary wall damage was an important factor in the pathogenesis of the extracapillary lesions in IgA nephropathy.en_US
dc.languageengen_US
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/00313025.aspen_US
dc.relation.ispartofPathologyen_US
dc.subject.meshAdulten_US
dc.subject.meshBasement Membrane - Pathologyen_US
dc.subject.meshCapillaries - Pathology - Ultrastructureen_US
dc.subject.meshFemaleen_US
dc.subject.meshFluorescent Antibody Techniqueen_US
dc.subject.meshGlomerular Filtration Rateen_US
dc.subject.meshGlomerulonephritis, Iga - Pathologyen_US
dc.subject.meshHumansen_US
dc.subject.meshKidney Glomerulus - Blood Supply - Pathology - Ultrastructureen_US
dc.subject.meshMaleen_US
dc.subject.meshMicroscopy, Electronen_US
dc.titlePeripheral glomerular capillary wall lesions in IgA nephropathy and their implicationsen_US
dc.typeArticleen_US
dc.identifier.emailChan, KW:hrmtckw@hku.hken_US
dc.identifier.authorityChan, KW=rp00330en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid6393013-
dc.identifier.scopuseid_2-s2.0-0021680644en_US
dc.identifier.volume16en_US
dc.identifier.issue3en_US
dc.identifier.spage324en_US
dc.identifier.epage330en_US
dc.identifier.isiWOS:A1984TB84600018-
dc.publisher.placeUnited Kingdomen_US

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