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Article: A scanning electron microscope study of isolated glomeruli in glomerulonephritis

TitleA scanning electron microscope study of isolated glomeruli in glomerulonephritis
Authors
Issue Date1983
PublisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/00313025.asp
Citation
Pathology, 1983, v. 15 n. 2, p. 139-146 How to Cite?
AbstractGlomeruli from 48 cases of glomerulonephritis (Gn) were isolated and studied by means of the scanning electron microscope (SEM). Overall glomerular loss due to processing was 2.4%. SEM of these isolated glomeruli showed good preservation of glomerular structure. Changes of the podocyte cell body and its foot processes were noted and correlated with light microscopic morphology. Individual podocyte necrosis, variable foot process fusion and cell body swelling were seen in IgA nephropathy. Podocyte degeneration with separation from the glomerular basement membrane was evident in idiopathic minimal change Gn while idiopathic membranous Gn was characterized by globular swelling of the podocyte cell bodies. In focal sclerosing Gn, large spherical bodies arising from swollen podocyte cell bodies were frequently encountered. Innumerable microvilli and small spherical bodies characterized membranoproliferative Gn. Variable podocyte cell body swelling, microvilli and small spherical bodies were seen in cases of lupus nephritis. Taken alone, none of the SEM changes were diagnostic. However, when the type of the change, the severity and the combination of the changes were considered as a whole, they were indicative of what light microscopy might reveal and helpful in differentiating between idiopathic minimal change Gn and focal sclerosing Gn.
Persistent Identifierhttp://hdl.handle.net/10722/147732
ISSN
2015 Impact Factor: 2.968
2015 SCImago Journal Rankings: 1.049
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorNg, WLen_US
dc.contributor.authorChan, KWen_US
dc.contributor.authorMa, Len_US
dc.date.accessioned2012-05-29T06:08:57Z-
dc.date.available2012-05-29T06:08:57Z-
dc.date.issued1983en_US
dc.identifier.citationPathology, 1983, v. 15 n. 2, p. 139-146en_US
dc.identifier.issn0031-3025en_US
dc.identifier.urihttp://hdl.handle.net/10722/147732-
dc.description.abstractGlomeruli from 48 cases of glomerulonephritis (Gn) were isolated and studied by means of the scanning electron microscope (SEM). Overall glomerular loss due to processing was 2.4%. SEM of these isolated glomeruli showed good preservation of glomerular structure. Changes of the podocyte cell body and its foot processes were noted and correlated with light microscopic morphology. Individual podocyte necrosis, variable foot process fusion and cell body swelling were seen in IgA nephropathy. Podocyte degeneration with separation from the glomerular basement membrane was evident in idiopathic minimal change Gn while idiopathic membranous Gn was characterized by globular swelling of the podocyte cell bodies. In focal sclerosing Gn, large spherical bodies arising from swollen podocyte cell bodies were frequently encountered. Innumerable microvilli and small spherical bodies characterized membranoproliferative Gn. Variable podocyte cell body swelling, microvilli and small spherical bodies were seen in cases of lupus nephritis. Taken alone, none of the SEM changes were diagnostic. However, when the type of the change, the severity and the combination of the changes were considered as a whole, they were indicative of what light microscopy might reveal and helpful in differentiating between idiopathic minimal change Gn and focal sclerosing Gn.en_US
dc.languageengen_US
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/00313025.aspen_US
dc.relation.ispartofPathologyen_US
dc.subject.meshBasement Membrane - Ultrastructureen_US
dc.subject.meshBiopsyen_US
dc.subject.meshGlomerulonephritis - Pathologyen_US
dc.subject.meshGlomerulosclerosis, Focal Segmental - Pathologyen_US
dc.subject.meshHumansen_US
dc.subject.meshKidney - Pathologyen_US
dc.subject.meshKidney Glomerulus - Ultrastructureen_US
dc.subject.meshLupus Erythematosus, Systemic - Pathologyen_US
dc.subject.meshMicroscopy, Electron, Scanningen_US
dc.subject.meshNephrosis, Lipoid - Pathologyen_US
dc.titleA scanning electron microscope study of isolated glomeruli in glomerulonephritisen_US
dc.typeArticleen_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid6888960-
dc.identifier.scopuseid_2-s2.0-0020560468en_US
dc.identifier.volume15en_US
dc.identifier.issue2en_US
dc.identifier.spage139en_US
dc.identifier.epage146en_US
dc.identifier.isiWOS:A1983QM23100006-
dc.publisher.placeUnited Kingdomen_US

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