File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Genetic susceptibility of intervertebral disc degeneration among young Finnish adults

TitleGenetic susceptibility of intervertebral disc degeneration among young Finnish adults
Authors
Issue Date2011
PublisherBioMed Central Ltd. The Journal's web site is located at http://www.biomedcentral.com/bmcmedgenet/
Citation
BMC Medical Genetics, 2011, v. 12, article no. 153 How to Cite?
AbstractBACKGROUND: Disc degeneration (DD) is a common condition that progresses with aging. Although the events leading to DD are not well understood, a significant genetic influence has been found. This study was undertaken to assess the association between relevant candidate gene polymorphisms and moderate DD in a well-defined and characterized cohort of young adults. Focusing on young age can be valuable in determining genetic predisposition to DD. METHODS: We investigated the associations of existing candidate genes for DD among 538 young adults with a mean age of 19 belonging to the 1986 Northern Finland Birth Cohort. Nineteen single nucleotide polymorphisms (SNP) in 16 genes were genotyped. We evaluated lumbar DD using the modified Pfirrmann classification and a 1.5-T magnetic resonance scanner for imaging. RESULTS: Of the 538 individuals studied, 46% had no degeneration, while 54% had DD and 51% of these had moderate DD. The risk of DD was significantly higher in subjects with an allele G of IL6 SNPs rs1800795 (OR 1.45, 95% CI 1.07-1.96) and rs1800797 (OR 1.37, 95% CI 1.02-1.85) in the additive inheritance model. The role of IL6 was further supported by the haplotype analysis, which resulted in an association between the GGG haplotype (SNPs rs1800797, rs1800796 and rs1800795) and DD with an OR of 1.51 (95% CI 1.11-2.04). In addition, we observed an association between DD and two other polymorphisms, SKT rs16924573 (OR 0.27 95% CI 0.07-0.96) and CILP rs2073711 in women (OR 2.04, 95% CI 1.07-3.89). CONCLUSION: Our results indicate that IL6, SKT and CILP are involved in the etiology of DD among young adults.
Persistent Identifierhttp://hdl.handle.net/10722/147652
ISSN
2015 Impact Factor: 2.094
2015 SCImago Journal Rankings: 1.062
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
Academy of Finland121620
115471
AOSPINEAOSBRC-07-2
Funding Information:

Supported in part by grants from the Academy of Finland (121620 and 115471) and AOSPINE (AOSBRC-07-2).

References

 

DC FieldValueLanguage
dc.contributor.authorKelempisioti, Aen_HK
dc.contributor.authorEskola, PJen_HK
dc.contributor.authorOkuloff, Aen_HK
dc.contributor.authorKarjalainen, Uen_HK
dc.contributor.authorTakatalo, Jen_HK
dc.contributor.authorDaavittila, Ien_HK
dc.contributor.authorNiinimaki, Jen_HK
dc.contributor.authorSequeiros, RBen_HK
dc.contributor.authorTervonen, Oen_HK
dc.contributor.authorSolovieva, Sen_HK
dc.contributor.authorKao, PYPen_HK
dc.contributor.authorSong, Yen_HK
dc.contributor.authorCheung, KMCen_HK
dc.contributor.authorChan, Den_HK
dc.contributor.authorAla-Kokko, Len_HK
dc.contributor.authorJarvelin, MRen_HK
dc.contributor.authorKarppinen, Jen_HK
dc.contributor.authorMannikko, Men_HK
dc.date.accessioned2012-05-29T06:05:15Z-
dc.date.available2012-05-29T06:05:15Z-
dc.date.issued2011en_HK
dc.identifier.citationBMC Medical Genetics, 2011, v. 12, article no. 153en_HK
dc.identifier.issn1471-2350en_HK
dc.identifier.urihttp://hdl.handle.net/10722/147652-
dc.description.abstractBACKGROUND: Disc degeneration (DD) is a common condition that progresses with aging. Although the events leading to DD are not well understood, a significant genetic influence has been found. This study was undertaken to assess the association between relevant candidate gene polymorphisms and moderate DD in a well-defined and characterized cohort of young adults. Focusing on young age can be valuable in determining genetic predisposition to DD. METHODS: We investigated the associations of existing candidate genes for DD among 538 young adults with a mean age of 19 belonging to the 1986 Northern Finland Birth Cohort. Nineteen single nucleotide polymorphisms (SNP) in 16 genes were genotyped. We evaluated lumbar DD using the modified Pfirrmann classification and a 1.5-T magnetic resonance scanner for imaging. RESULTS: Of the 538 individuals studied, 46% had no degeneration, while 54% had DD and 51% of these had moderate DD. The risk of DD was significantly higher in subjects with an allele G of IL6 SNPs rs1800795 (OR 1.45, 95% CI 1.07-1.96) and rs1800797 (OR 1.37, 95% CI 1.02-1.85) in the additive inheritance model. The role of IL6 was further supported by the haplotype analysis, which resulted in an association between the GGG haplotype (SNPs rs1800797, rs1800796 and rs1800795) and DD with an OR of 1.51 (95% CI 1.11-2.04). In addition, we observed an association between DD and two other polymorphisms, SKT rs16924573 (OR 0.27 95% CI 0.07-0.96) and CILP rs2073711 in women (OR 2.04, 95% CI 1.07-3.89). CONCLUSION: Our results indicate that IL6, SKT and CILP are involved in the etiology of DD among young adults.en_HK
dc.languageengen_US
dc.publisherBioMed Central Ltd. The Journal's web site is located at http://www.biomedcentral.com/bmcmedgenet/en_HK
dc.relation.ispartofBMC Medical Geneticsen_HK
dc.rightsBMC Medical Genetics. Copyright © BioMed Central Ltd.-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshExtracellular Matrix Proteins - genetics-
dc.subject.meshGenetic Predisposition to Disease - genetics-
dc.subject.meshInterleukin-6 - genetics-
dc.subject.meshIntervertebral Disc Degeneration - epidemiology - genetics - pathology-
dc.subject.meshPyrophosphatases - genetics-
dc.titleGenetic susceptibility of intervertebral disc degeneration among young Finnish adultsen_HK
dc.typeArticleen_HK
dc.identifier.emailKao, PYP: h0102925@graduate.hku.hken_HK
dc.identifier.emailSong, Y: songy@hku.hken_HK
dc.identifier.emailCheung, KMC: cheungmc@hku.hken_HK
dc.identifier.emailChan, D: chand@hku.hk-
dc.identifier.emailMannikko, M: minna.mannikko@oulu.fi-
dc.identifier.authoritySong, YQ=rp00488en_HK
dc.identifier.authorityCheung, KMC=rp00387en_HK
dc.identifier.authorityChan, D=rp00540en_HK
dc.description.naturepublished_or_final_versionen_US
dc.identifier.doi10.1186/1471-2350-12-153en_HK
dc.identifier.pmid22107760-
dc.identifier.pmcidPMC3235967-
dc.identifier.scopuseid_2-s2.0-81455161612en_HK
dc.identifier.hkuros207202-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-81455161612&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume12, article no. 153en_HK
dc.identifier.isiWOS:000298055000001-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridMännikkö, M=6603251095en_HK
dc.identifier.scopusauthoridKarppinen, J=7004560479en_HK
dc.identifier.scopusauthoridJärvelin, MR=18535933700en_HK
dc.identifier.scopusauthoridAlaKokko, L=7005509196en_HK
dc.identifier.scopusauthoridChan, D=7402216545en_HK
dc.identifier.scopusauthoridCheung, KMC=7402406754en_HK
dc.identifier.scopusauthoridSong, YQ=7404921212en_HK
dc.identifier.scopusauthoridKao, PYP=24280722500en_HK
dc.identifier.scopusauthoridSolovieva, S=6603868284en_HK
dc.identifier.scopusauthoridTervonen, O=7005142862en_HK
dc.identifier.scopusauthoridSequeiros, RB=6507512568en_HK
dc.identifier.scopusauthoridNiinimäki, J=7003958147en_HK
dc.identifier.scopusauthoridDaavittila, I=23666837700en_HK
dc.identifier.scopusauthoridTakatalo, J=35337843900en_HK
dc.identifier.scopusauthoridKarjalainen, U=54938021200en_HK
dc.identifier.scopusauthoridOkuloff, A=36509025700en_HK
dc.identifier.scopusauthoridEskola, PJ=36508463500en_HK
dc.identifier.scopusauthoridKelempisioti, A=35327058900en_HK
dc.identifier.citeulike10061211-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats