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Article: Polymorphisms of CR1, CLU and PICALM confer susceptibility of Alzheimer's disease in a southern Chinese population

TitlePolymorphisms of CR1, CLU and PICALM confer susceptibility of Alzheimer's disease in a southern Chinese population
Authors
Issue Date2012
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/neuaging
Citation
Neurobiology of Aging, 2012, v. 33 n. 1, p. 210.e1-210.e7 How to Cite?
AbstractIn this case-controlled study, we tested susceptible genetic variants for Alzheimer's disease (AD) in CR1, CLU and PICALM from genome-wide association studies (GWAS) in a southern Chinese population. Eight hundred twelve participants consisting of 462 late-onset Alzheimer's disease (LOAD) patients and 350 nondemented control subjects were recruited. We found by multivariate logistic regression analysis, that single nucleotide polymorphisms (SNPs) in CR1 (rs6656401 adjusted allelic p = 0.035; adjusted genotypic p = 0.043) and CLU (rs2279590 adjusted allelic p = 0.035; adjusted genotypic p = 0.006; rs11136000 adjusted allelic p = 0.038; adjusted genotypic p = 0.009) were significantly different between LOAD patients and nondemented controls. For PICALM, LOAD association was found only in the APOE ε4 (-) subgroup (rs3851179 adjusted allelic p = 0.028; adjusted genotypic p = 0.013). Our findings showed evidence of CR1, CLU, and PICALM and LOAD susceptibility in an independent southern Chinese population, which provides additional evidence for LOAD association apart from prior genome-wide association studies in Caucasian populations. © 2012 Elsevier Inc.
Persistent Identifierhttp://hdl.handle.net/10722/147651
ISSN
2015 Impact Factor: 5.153
2015 SCImago Journal Rankings: 2.613
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChen, LHen_US
dc.contributor.authorKao, PYPen_US
dc.contributor.authorFan, YHen_US
dc.contributor.authorHo, DTYen_US
dc.contributor.authorChan, CSYen_US
dc.contributor.authorYik, PYen_US
dc.contributor.authorHa, JCTen_US
dc.contributor.authorChu, LWen_US
dc.contributor.authorSong, YQen_US
dc.date.accessioned2012-05-29T06:05:14Z-
dc.date.available2012-05-29T06:05:14Z-
dc.date.issued2012en_US
dc.identifier.citationNeurobiology of Aging, 2012, v. 33 n. 1, p. 210.e1-210.e7en_US
dc.identifier.issn0197-4580en_US
dc.identifier.urihttp://hdl.handle.net/10722/147651-
dc.description.abstractIn this case-controlled study, we tested susceptible genetic variants for Alzheimer's disease (AD) in CR1, CLU and PICALM from genome-wide association studies (GWAS) in a southern Chinese population. Eight hundred twelve participants consisting of 462 late-onset Alzheimer's disease (LOAD) patients and 350 nondemented control subjects were recruited. We found by multivariate logistic regression analysis, that single nucleotide polymorphisms (SNPs) in CR1 (rs6656401 adjusted allelic p = 0.035; adjusted genotypic p = 0.043) and CLU (rs2279590 adjusted allelic p = 0.035; adjusted genotypic p = 0.006; rs11136000 adjusted allelic p = 0.038; adjusted genotypic p = 0.009) were significantly different between LOAD patients and nondemented controls. For PICALM, LOAD association was found only in the APOE ε4 (-) subgroup (rs3851179 adjusted allelic p = 0.028; adjusted genotypic p = 0.013). Our findings showed evidence of CR1, CLU, and PICALM and LOAD susceptibility in an independent southern Chinese population, which provides additional evidence for LOAD association apart from prior genome-wide association studies in Caucasian populations. © 2012 Elsevier Inc.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/neuagingen_US
dc.relation.ispartofNeurobiology of Agingen_US
dc.rightsNOTICE: this is the author’s version of a work that was accepted for publication in Neurobiology of Aging. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Neurobiology of Aging, 2012, v. 33 n. 1, p. 210.e1-210.e7. DOI: 10.1016/j.neurobiolaging.2011.09.016-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshAlzheimer Disease - Geneticsen_US
dc.subject.meshApolipoprotein E4 - Geneticsen_US
dc.subject.meshAsian Continental Ancestry Group - Geneticsen_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshClusterin - Geneticsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenetic Association Studiesen_US
dc.subject.meshGenetic Predisposition To Disease - Geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMonomeric Clathrin Assembly Proteins - Geneticsen_US
dc.subject.meshMultivariate Analysisen_US
dc.subject.meshPolymorphism, Single Nucleotideen_US
dc.subject.meshReceptors, Complement 3B - Geneticsen_US
dc.titlePolymorphisms of CR1, CLU and PICALM confer susceptibility of Alzheimer's disease in a southern Chinese populationen_US
dc.typeArticleen_US
dc.identifier.emailSong, YQ:songy@hkucc.hku.hken_US
dc.identifier.authoritySong, YQ=rp00488en_US
dc.description.naturepostprinten_US
dc.identifier.doi10.1016/j.neurobiolaging.2011.09.016en_US
dc.identifier.pmid22015308-
dc.identifier.scopuseid_2-s2.0-81355148562en_US
dc.identifier.hkuros205931-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-81355148562&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume33en_US
dc.identifier.issue1en_US
dc.identifier.spage210.e1en_US
dc.identifier.epage210.e7en_US
dc.identifier.eissn1558-1497-
dc.identifier.isiWOS:000297934700057-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridChen, LH=54584975000en_US
dc.identifier.scopusauthoridKao, PYP=24280722500en_US
dc.identifier.scopusauthoridFan, YH=37461378000en_US
dc.identifier.scopusauthoridHo, DTY=54585293500en_US
dc.identifier.scopusauthoridChan, CSY=7404813785en_US
dc.identifier.scopusauthoridYik, PY=15060623700en_US
dc.identifier.scopusauthoridHa, JCT=54585132200en_US
dc.identifier.scopusauthoridChu, LW=7202236665en_US
dc.identifier.scopusauthoridSong, YQ=7404921212en_US
dc.identifier.citeulike9949130-

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